[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645231":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":25,"responsibleParty":91,"collaborators":94,"id":103,"slug":104,"hasResults":105,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":105,"sex":111,"minAge":112,"maxAge":10,"enrollmentInfo":113,"targetDuration":10,"studyType":116,"phases":10,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"University of Bari","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Fibromyalgia cases",null,"Adults with fibromyalgia diagnosed per the 2016 ACR criteria.",{"label":13,"type":10,"description":14,"interventionNames":10},"Non-fibromyalgia chronic pain controls","Adults with chronic non-cancer pain of defined nociceptive or neuropathic origin who do not meet the 2016 ACR criteria for fibromyalgia.",[16],{"name":17,"affiliation":18,"role":19},"Alberto Corriero, MD, PhD","University of Bari Aldo Moro, Pain and ICU Section","PRINCIPAL_INVESTIGATOR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","+39 3280072443","alberto.corriero@gmail.com",[26,45,58,69,80],{"facility":27,"status":28,"city":29,"state":10,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Pain Unit, Policlinico di Bari, University of Bari Aldo Moro (coordinating center)","RECRUITING","Bari","70124","Italy","IT",{"type":34,"coordinates":35},"Point",[36,37],16.86982,41.12066,{"lat":37,"lon":36},[40,42,43],{"name":41,"role":19,"phone":10,"phoneExt":10,"email":10},"Filomena Puntillo, MD",{"name":17,"role":19,"phone":10,"phoneExt":10,"email":10},{"name":44,"role":19,"phone":10,"phoneExt":10,"email":10},"Mariateresa Giglio, MD",{"facility":46,"status":47,"city":48,"state":10,"zip":49,"country":31,"countryCode":32,"cosmosGeoPoint":50,"geoPoint":54,"contacts":55},"Anesthesia and Pain Therapy Unit, IRCCS AOSP di Bologna, Policlinico S. Orsola-Malpighi","NOT_YET_RECRUITING","Bologna","40138",{"type":34,"coordinates":51},[52,53],11.33875,44.49381,{"lat":53,"lon":52},[56],{"name":57,"role":19,"phone":10,"phoneExt":10,"email":10},"Samolsky Dekel Boaz, MD",{"facility":59,"status":47,"city":60,"state":10,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Department of Medical Sciences and Public Health, University of Cagliari","Cagliari",{"type":34,"coordinates":62},[63,64],9.11917,39.23054,{"lat":64,"lon":63},[67],{"name":68,"role":19,"phone":10,"phoneExt":10,"email":10},"Gabriele Finco, MD",{"facility":70,"status":47,"city":71,"state":10,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Department of Women, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli","Naples",{"type":34,"coordinates":73},[74,75],14.26811,40.85216,{"lat":75,"lon":74},[78],{"name":79,"role":19,"phone":10,"phoneExt":10,"email":10},"Maria Caterina Pace, MD",{"facility":81,"status":47,"city":82,"state":10,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona","Verona",{"type":34,"coordinates":84},[85,86],10.9938,45.43854,{"lat":86,"lon":85},[89],{"name":90,"role":19,"phone":10,"phoneExt":10,"email":10},"Vittorio Schweiger, MD, PhD",{"type":19,"investigatorFullName":17,"investigatorTitle":92,"investigatorAffiliation":93,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator","University of Bari Aldo Moro",[95,97,99,101],{"name":96,"class":6},"Universita di Verona",{"name":98,"class":6},"University of Campania Luigi Vanvitelli",{"name":100,"class":6},"University of Cagliari",{"name":102,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","100645231","emotional-allodynia-questionnaire-aeq-in-fibromyalgia-pearl-100645231",false,"NCT07677631","Emotional Allodynia Questionnaire (AEQ) in Fibromyalgia (PEARL)","Pain, Emotional Allodynia, and Relational Load (PEARL): A Multicenter Validation Study of the Emotional Allodynia Questionnaire in Fibromyalgia","PEARL","CASES (fibromyalgia)\n\nInclusion Criteria:\n\n* Age 18 years or older\n* Clinical diagnosis of fibromyalgia confirmed according to the 2016 revision of the ACR criteria\n* Chronic non-cancer pain for at least 3 months\n* Ability to understand and independently complete self-report questionnaires in Italian\n* Willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Active oncological disease or cancer-related pain\n* Any current or past psychiatric diagnosis except Major Depressive Disorder and Panic Disorder (assessed by clinical history)\n* Severe cognitive impairment precluding questionnaire completion\n* Inability to understand or complete questionnaires in Italian\n\nCONTROLS (non-fibromyalgia chronic pain)\n\nInclusion Criteria:\n\n* Age 18 years or older\n* Chronic non-cancer pain for at least 3 months with a defined nociceptive or neuropathic generator (e.g., radiologically or surgically documented degenerative, structural, or post-surgical musculoskeletal pain, or neuropathic pain with an identifiable neurological lesion or disease)\n* Not meeting the 2016 ACR criteria for fibromyalgia\n* Ability to understand and independently complete self-report questionnaires in Italian\n* Willingness to provide written informed consent\n\nExclusion Criteria (parallel to cases):\n\n* Diagnosis of fibromyalgia or another recognized nociplastic primary pain condition (e.g., primary chronic widespread pain)\n* Active oncological disease or cancer-related pain\n* Any current or past psychiatric diagnosis except Major Depressive Disorder and Panic Disorder\n* Severe cognitive impairment precluding questionnaire completion\n* Inability to understand or complete questionnaires in Italian\n\nNote: ongoing pharmacological treatment for pain or mental health is not an exclusion criterion in either group; Major Depressive Disorder and Panic Disorder are recorded at baseline and used in covariate-adjusted and stratified analyses.","ALL","18 Years",{"count":114,"type":115},423,"ESTIMATED","OBSERVATIONAL","The Emotional Allodynia Questionnaire (AEQ) is an 11-item self-report instrument that measures disproportionate emotional reactivity to low-intensity interpersonal cues(perceived unresponsiveness, exclusion, loss of reciprocity), a pattern termed emotional allodynia. It was preliminarily validated in a single-center fibromyalgia sample. PEARL (validation phase) is a multicenter, prospective, observational psychometric validation study that (1) replicates the internal structure and convergent validity of the AEQ in an independent fibromyalgia sample, (2) tests its known-groups (discriminative) accuracy in separating fibromyalgia from non-fibromyalgia chronic pain of defined nociceptive or neuropathic origin, expressed as the area under the ROC curve (AUC), and (3) assesses test-retest reliability. There is no intervention.",[119,120,121],"Fibromyalgia","Chronic Pain","Nociplastic Pain",[123,119,124,125,126,127],"Emotional Allodynia Questionnaire","Nociplastic pain","Psychometric validation","Central sensitization","Emotion regulation","2026-06-24",{"date":130,"type":131},"2026-07-01","ACTUAL",{"date":133,"type":131},"2025-09-10",{"date":135,"type":115},"2027-08",{"name":5,"class":6},5]