[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569534":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":105,"collaborators":107,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":118,"sex":123,"minAge":124,"maxAge":10,"enrollmentInfo":125,"targetDuration":10,"studyType":128,"phases":10,"briefSummary":129,"conditions":130,"keywords":133,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"The Christie NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"All participants",null,"Blood sample collection for gene panel array testing and simultaneous research purposes",[13,14],"Diagnostic Test: Gene panel array","Other: Blood Sample Collection",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","Gene panel array","Blood sample collection for gene panel testing",[9],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Blood Sample Collection","Blood sample collection for research purposes",[9],[26],{"name":27,"affiliation":28,"role":29},"Natalie Cook","The University of Manchester","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"EGG CUP Study Team","CONTACT","+44 161 918 7672","the-christie.egg-cup@nhs.net",[37,52,64,75,83,94],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Manchester","Greater Manchester","M20 4BX","United Kingdom","UK",{"type":45,"coordinates":46},"Point",[47,48],-2.23743,53.48095,{"lat":48,"lon":47},[51],{"name":27,"role":29,"phone":10,"phoneExt":10,"email":10},{"facility":53,"status":38,"city":54,"state":55,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"The Clatterbridge Cancer Centre NHS Foundation Trust","Liverpool","Merseyside",{"type":45,"coordinates":57},[58,59],-2.97794,53.41058,{"lat":59,"lon":58},[62],{"name":63,"role":29,"phone":10,"phoneExt":10,"email":10},"Eliyaz Ahmed",{"facility":65,"status":38,"city":66,"state":10,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Blackpool Teaching Hospitals NHS Foundation Trust","Blackpool",{"type":45,"coordinates":68},[69,70],-3.05,53.81667,{"lat":70,"lon":69},[73],{"name":74,"role":29,"phone":10,"phoneExt":10,"email":10},"Pavel Bezecny",{"facility":76,"status":38,"city":39,"state":10,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":77,"geoPoint":79,"contacts":80},"Northern Care Alliance NHS Foundation Trust",{"type":45,"coordinates":78},[47,48],{"lat":48,"lon":47},[81],{"name":82,"role":29,"phone":10,"phoneExt":10,"email":10},"Paul O'Donnell",{"facility":84,"status":38,"city":85,"state":10,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"University Hospitals of Morecambe Bay NHS Trust","Morecambe",{"type":45,"coordinates":87},[88,89],-2.86108,54.06835,{"lat":89,"lon":88},[92],{"name":93,"role":29,"phone":10,"phoneExt":10,"email":10},"N Chan Ton",{"facility":95,"status":38,"city":96,"state":10,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Lancashire Teaching Hospitals NHS Foundation Trust","Preston",{"type":45,"coordinates":98},[99,100],-2.70452,53.76282,{"lat":100,"lon":99},[103],{"name":104,"role":29,"phone":10,"phoneExt":10,"email":10},"Catherine Mitchell",{"type":106,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[108,111,114],{"name":109,"class":110},"National Institute for Health Research, United Kingdom","OTHER_GOV",{"name":112,"class":113},"Hoffmann-La Roche","INDUSTRY",{"name":115,"class":6},"University of Manchester","100569534","enabling-genomic-testing-in-cancer-of-unknown-primary-100569534",false,"NCT06695494","Enabling Genomic Testing in Cancer of Unknown Primary","EGGCUP","Inclusion Criteria:\n\n1. Aged 16 years or over\n2. Written informed consent according to ICH\u002FGCP and national regulations\n3. ECOG Performance status 0-2\n4. Confirmed diagnosis of CUP as per the ESMO guidelines. Patients must have;\n\n   1. The local pathology reports confirming compatibility with CUP diagnosis and the associated slides used for the diagnosis\n   2. Discussion at a local CUP MDT confirming diagnosis\n5. Availability of archival tumour histological report\n6. Willingness to provide blood samples on up to two occasions during the study\n\nExclusion Criteria:\n\n1. Patient with an immunohistochemistry profile that provides a definitive clinical indication of a primary cancer with a specific treatment\n2. Known HIV, Hepatitis B, C positive, due to the difficulties in handling high-risk specimens\n3. Patients who are unable to provide fully informed written consent\n4. Presence of any medical, psychological, familial or sociological condition that, in the investigator's opinion, will hamper compliance with the study protocol and follow-up schedule\n5. Bleeding diathesis (patients' on anticoagulation are permitted to enter the trial if anticoagulation can be safely managed to enable blood sampling)\n6. Conditions in which blood sampling may increase risk of complications for the patients and\u002For investigator","ALL","16 Years",{"count":126,"type":127},100,"ESTIMATED","OBSERVATIONAL","Cancer of Unknown Primary (CUP) is where cancer cells are found in the body but the place the cancer began is not known. It is the 6th leading cause of cancer death in the UK and the prognosis is poor with a median survival of 6-9 months. There is a higher than average incidence of CUP in the North West (NW) of England (population of 7.4 million). Precision medicine has transformed treatment strategies in known tumour types, however in CUP there remains an urgent need to better understand CUP molecular characteristics to establish potential roles for novel therapeutic strategies. Treatment options remain limited due to difficulties in determining the primary site of the tumour and the lack of access to validated biomarkers. Access to good-quality tissue for molecular profiling remains a huge challenge in CUP. The emergence of liquid biopsies (sequence DNA in a blood test) as a source of biomarkers is also gaining rapid ground and this study aims to explore the potential utility of liquid biopsies in CUP.",[131,132],"Cancer of Unknown Primary","Neoplasm, Unknown Primary",[134,135],"Cancer of unknown primary","Cancer","2026-03-24",{"date":138,"type":139},"2026-03-25","ACTUAL",{"date":141,"type":139},"2024-08-15",{"date":143,"type":127},"2027-12-01",{"name":5,"class":6},6]