[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597097":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":39,"locations":47,"responsibleParty":64,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":24,"enrollmentInfo":79,"targetDuration":24,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":50,"whyStopped":24,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Centre Hospitalier St Anne","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"surgical arm","ACTIVE_COMPARATOR","carotid endarterectomy",[13],"Procedure: carotid endarterectomy",{"label":15,"type":10,"description":16,"interventionNames":17},"Stenting arm","Carotid artery stenting",[18],"Procedure: Carotid artery stenting",[20,25],{"type":21,"name":11,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Carotid endarterectomy is a surgical procedure used to reduce the risk of stroke due to carotid artery stenosis. During an endarterectomy, the surgeon opens the artery and removes the plaque.",[9],null,{"type":21,"name":16,"description":26,"armGroupLabels":27,"otherNames":24},"Carotid artery stenting is an endovascular procedure in which a stent is deployed in the lumen of the carotid artery to treat narrowing of the carotid artery and reduce the risk of stroke.",[15],[29,33,36],{"name":30,"affiliation":31,"role":32},"David Calvet, Professor","GHU Sainte-Anne, PARIS","STUDY_DIRECTOR",{"name":34,"affiliation":35,"role":32},"Benjamin GORY, Professor","Central Hospital, Nancy, France",{"name":37,"affiliation":38,"role":32},"Antoine MILLON, Professor","Hospices Civils de Lyon",[40,44],{"name":30,"role":41,"phone":42,"phoneExt":24,"email":43},"CONTACT","+33145658634","d.calvet@ghu-paris.fr",{"name":45,"role":41,"phone":24,"phoneExt":24,"email":46},"DRCI DRCI","info-recherche@ghu-paris.fr",[48],{"facility":49,"status":50,"city":51,"state":24,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Centre hospitalier Sainte-Anne","RECRUITING","Paris","75014","France","FR",{"type":56,"coordinates":57},"Point",[58,59],2.3488,48.85341,{"lat":59,"lon":58},[62],{"name":63,"role":41,"phone":24,"phoneExt":24,"email":43},"David Calvet",{"type":65,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[67],{"name":68,"class":69},"Direction Générale de l'Offre de Soins","OTHER_GOV","100597097","endarterectomy-versus-stenting-in-patients-with-symptomatic-severe-carotid-stenosis---2-100597097",false,"NCT07054060","Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2","EVA3S-2","Inclusion Criteria:\n\n* Patient age 18 years or over\n* Hemispheric or retinal transient ischemic attack or a non-disabling stroke (or retinal infarct) within 15 days before enrolment\n* Stenosis of 50% to 99% in the symptomatic carotid artery (NASCET method) for whom revascularisation is decided according to guidelines\n\nExclusion Criteria:\n\n* Patients unwilling or unable to participate in follow-up for whatever reason\n* Preexisting disability (Modified Rankin Score ≥ 3)\n* Nonatherosclerotic carotid disease\n* Severe tandem lesions\n* Previous revascularization of the symptomatic carotid stenosis\n* History of bleeding disorder\n* Unstable angina\n* Contraindication to dual antiplatelet therapy\n* Contraindication to MRI\n* Life expectancy of less than 2 years\n* Percutaneaous or surgical intervention within 30 days before or after the study procedure\n* Stenotic lesion on arterial workup appeared as not a factor in the selection","ALL","18 Years",{"count":80,"type":81},600,"ESTIMATED","INTERVENTIONAL",[84],"NA","Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks. Randomized clinical trials (RCTs) have demonstrated the benefits of carotid endarterectomy (CEA) in reducing stroke risk in patients with severe symptomatic carotid stenosis. Carotid artery stenting (CAS) has been developed as an alternative to CEA, offering several potential advantages, such as avoiding local surgical complications. However, unlike CEA, CAS has not been compared to medical therapy in RCTs for symptomatic carotid stenosis.",[87],"Stroke",[89,90,91,92,93],"CEA, CAS","stroke","Magnetic resonance imaging","Carotid Artery Stenting","Carotid Endarterectomy","2025-07-23",{"date":96,"type":97},"2025-07-24","ACTUAL",{"date":99,"type":97},"2025-07-16",{"date":101,"type":81},"2028-03-16",{"name":5,"class":6},1]