[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597553":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":38,"locations":47,"responsibleParty":62,"collaborators":24,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":24,"enrollmentInfo":76,"targetDuration":24,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":24,"overallStatus":86,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Karolinska University Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"ICU Patients","EXPERIMENTAL","Mechanically ventilated patients admitted to the study site ICU.",[13,14],"Other: Stable isotope tracers","Dietary Supplement: Parenteral nutrition",{"label":16,"type":10,"description":17,"interventionNames":18},"Control group","Non-hospitalized study subjects recruited through public advertising at the study site, age-matched on group level.",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Stable isotope tracers","Deuterium-labelled non-radioactive stable isotopes of glucose, phenylalanine and glycerol.",[16,9],null,{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":24},"DIETARY_SUPPLEMENT","Parenteral nutrition","Parenteral nutrition infused a rate corresponding to 100% of measured energy expenditure, started after blood sampling during a baseline fasting period.",[16,9],[31,35],{"name":32,"affiliation":33,"role":34},"Olav Rooyackers, PhD","Karolinska University Hospital\u002FKarolinska Institute","STUDY_CHAIR",{"name":36,"affiliation":33,"role":37},"Martin Sundström Rehal, MD PhD","PRINCIPAL_INVESTIGATOR",[39,43],{"name":36,"role":40,"phone":41,"phoneExt":24,"email":42},"CONTACT","+46812381507","martin.sundstrom-rehal@regionstockholm.se",{"name":44,"role":40,"phone":45,"phoneExt":24,"email":46},"Timo Oosterveld, MD","0046701466533","timo.oosterveld@ki.se",[48],{"facility":49,"status":24,"city":50,"state":24,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Karolinska University Hospital Huddinge","Stockholm","14186","Sweden","SE",{"type":55,"coordinates":56},"Point",[57,58],18.06871,59.32938,{"lat":58,"lon":57},[61],{"name":36,"role":40,"phone":41,"phoneExt":24,"email":42},{"type":37,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Martin Sundstrom Rehal","Principal Investigator","100597553","endogenous-energy-production-in-critically-ill-patients-100597553",false,"NCT07059988","Endogenous Energy Production in Critically Ill Patients","The Effect of Nutrition on Endogenous Energy Substrate Production in the Early and Late Acute Phase of Critical Illness","eEPIC","Inclusion Criteria:\n\nFor the ICU group:\n\n1. ≥18 years old and admitted to the ICU\n2. Invasive mechanical ventilation\n3. Arterial and central line in situ\n4. Expected to remain in ICU \\>72 hours\n\nFor the control group:\n\n1\\. ≥18 years old\n\nExclusion Criteria:\n\n1. Lack of informed consent by patient\u002Fnext of kin\n2. Liver transplant\n3. Acute or acute on chronic liver failure\n4. Cirrhosis\n5. Known diabetes mellitus\n6. Pancreatic surgery\n7. Acute or chronic pancreatitis\n8. Pregnancy\n9. Intubated only for airway protection or neurologic deficit\n10. Mitochondrial disease\n11. Disorder of amino acid metabolism\n12. Familial hypertriglyceridemia\n13. Severe acquired hypertriglyceridemia (≥10 mmol\u002FL)\n14. Requiring treatment of hypoglycemia in the last 72 hours before inclusion.\n15. Requiring ongoing large volume resuscitation of crystalloids or blood products\n16. \\>72 hours in ICU before enrollment\n17. Readmission to ICU within 1 week of ICU discharge.\n18. Morbidly obese (BMI ≥35)\n19. Limitations of treatment to best supportive care\n20. Ongoing treatment with insulin\u002Fglucose related to hyperkalemia",true,"ALL","18 Years",{"count":77,"type":78},40,"ESTIMATED","INTERVENTIONAL",[81],"NA","The aim of this study is to investigate when critically ill patients transition from a non-suppressible catabolism to a normal response to feeding.\n\nEndogenous production of glucose, fat and protein will be studied on a minimum of two occasions in mechanically ventilated ICU patients, in a fasted state and during parenteral nutrition. Substrate kinetics are estimated by a tracer dilution method using infusions of isotopically labeled glucose, glycerol and phenylalanine. Blood sampling for metabolomics analysis will be performed to elucidate potential biomarkers indicating an anabolic response to nutrition.",[84,85],"Critical Illness","Metabolism and Nutrition Disorder","NOT_YET_RECRUITING","2025-07-01",{"date":89,"type":90},"2025-07-11","ACTUAL",{"date":92,"type":78},"2025-07",{"date":94,"type":78},"2027-05",{"name":5,"class":6},1]