[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592122":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":39,"locations":44,"responsibleParty":84,"collaborators":87,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":26,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":101,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":26,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":121,"overallStatus":47,"whyStopped":26,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Idiopathic Calcium Oxalate Kidney Stone Patients","EXPERIMENTAL","Low oxalate fixed diets. oral glycolate and ascorbic acid administration",[13,14,15],"Dietary Supplement: Low-oxalate diet and glycolate dosing","Dietary Supplement: Oral glycolate dosing","Dietary Supplement: Oral 13C- ascorbic acid dosing",{"label":17,"type":18,"description":11,"interventionNames":19},"Healthy non-kidney stone forming individuals","ACTIVE_COMPARATOR",[13,14,15],[21,27,31],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Low-oxalate diet and glycolate dosing","Low-oxalate diet 4 days of fixed eucaloric diet with low oxalate (\\\u003C60 mg\u002Fday), normal calcium content (600-1000 mg\u002Fday)",[17,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Oral glycolate dosing","Oral 13C-glycolate dosing (0.5 mg\u002Fkg)",[17,9],{"type":22,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"Oral 13C- ascorbic acid dosing","Oral 13C- ascorbic acid dosing (0.75 mg\u002Fkg)",[17,9],[36],{"name":37,"affiliation":5,"role":38},"Sonia Fargue, PhD","PRINCIPAL_INVESTIGATOR",[40],{"name":37,"role":41,"phone":42,"phoneExt":26,"email":43},"CONTACT","205-975-6932","sfargue@uabmc.edu",[45,66],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"United States, Alabama University of Alabama at Birmingham","RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-86.80249,33.52066,{"lat":57,"lon":56},[60,61,65],{"name":37,"role":41,"phone":42,"phoneExt":26,"email":43},{"name":62,"role":41,"phone":63,"phoneExt":26,"email":64},"Research Coordinator","205-934-5712","kidneystone@uabmc.edu",{"name":37,"role":38,"phone":26,"phoneExt":26,"email":26},{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":51,"countryCode":52,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"University of Texas South Western Medical Center","NOT_YET_RECRUITING","Dallas","Texas","75390",{"type":54,"coordinates":73},[74,75],-96.80667,32.78306,{"lat":75,"lon":74},[78,81,83],{"name":79,"role":41,"phone":26,"phoneExt":26,"email":80},"Naim Maalouf, MD","Naim.Maalouf@UTSouthwestern.edu",{"name":62,"role":41,"phone":26,"phoneExt":26,"email":82},"Esperanza.Jackson@UTSouthwestern.edu",{"name":79,"role":38,"phone":26,"phoneExt":26,"email":26},{"type":38,"investigatorFullName":85,"investigatorTitle":86,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Sonia Fargue","Associate professor",[88,90],{"name":89,"class":6},"University of Texas, Southwestern Medical Center at Dallas",{"name":91,"class":92},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100592122","endogenous-oxalate-synthesis-in-idiopathic-calcium-oxalate-kidney-stone-disease-100592122",false,"NCT06989320","Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease","Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Formers","Inclusion Criteria:\n\n* age 18-80 yrs\n* Body Mass Index \\> 18.5 kg\u002Fm2\n* Normal fasting serum electrolytes on comprehensive metabolic profile\n* Willing to ingest fixed diets\n* Willing to stop supplements (vitamins including vitamin C, calcium (citrate or carbonate) and other minerals, herbal supplements, nutritional aids, probiotics) for 2 weeks before start and during study.\n* For stone formers: first time or recurrent Calcium Oxalate stone former. Composition of most recent stone ≥ 50% calcium oxalate if available, uric acid component \\\u003C20%\n\nExclusion Criteria:\n\n* Chronic Kidney Disease stage 4-5\n* Primary hyperoxaluria, Enteric (secondary) hyperoxaluria\n* Liver, bowel, endocrine or renal diseases (other than idiopathic Calcium Oxalate kidney stones) or any other condition that may influence the absorption, transport or urinary excretion of ions, which will compromise the interpretation of results, including: Cystic fibrosis, Celiac disease, Cystinuria, Uric acid stone former, Nephrotic syndrome, Sarcoidosis, Renal tubular acidosis, Primary hyperparathyroidism, Neurogenic bladder, Urinary diversion, Chronic diarrhea, Bariatric surgery, Inflammatory bowel disease\n* Pregnancy or breast-feeding\n* Incompatible dietary requirements with the study, food allergies or intolerance to any of the foods in study menus\n* Active malignancy or treatment for malignancy within 12 months prior to screening\n* Utilization of immunosuppressive medication\n* Uncontrolled hypertension or diabetes\n* Diabetes type 1",true,"ALL","18 Years","80 Years",{"count":105,"type":106},80,"ESTIMATED","INTERVENTIONAL",[109],"NA","The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate.\n\nThe study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones.\n\nParticipants will\n\ningest fixed diets containing low amounts of oxalate for 5 days ingest a soluble form of glycolate and vitamin C collect urine, blood, stool during the dietary and oral dosing portions of the study and also collect breath sample during the oral glycolate test",[112,113,114,115,116,117,118,119,120],"Kidney Stones","Kidney Calculi","Urolithiasis","Urolithiasis, Calcium Oxalate","Nephrolithiasis","Nephrolithiasis, Calcium Oxalate","Oxalate Urolithiasis","Healthy","Healthy Volunteer",[122],"oxalate synthesis","2026-05-27",{"date":125,"type":126},"2026-05-29","ACTUAL",{"date":128,"type":126},"2025-05-27",{"date":130,"type":106},"2031-12-31",{"name":5,"class":6},2]