[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644889":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":34,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":77,"overallStatus":83,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Mỹ Đức Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Exogenous steroid protocol",null,"The endometrium will be prepared with the use of oral estradiol valerate (Progynova®; Delpharm Lille SAS, France, or Valiera®, Laboratorios Recalcine) at a dose of 6 mg per day, starting on the second, third, or fourth day of the menstrual cycle. Endometrial thickness will be monitored from day 10 onward, and vaginal progesterone (Cyclogest, LD Collins, UK) at 800 mg per day and dydrogesterone (Duphaston, Abbott Biologicals B.V, US) at 20 mg per day will be started when the endometrial thickness reaches 8 mm or more. Embryo transfer was performed at 4 days for cleavage embryo transfer or at 6 days for blastocyst embryo transfer, after progesterone was started. All embryos were warmed on the day of transfer. Vaginal progesterone administration will be maintained until the day of the pregnancy test. In the event of a positive test result, luteal phase support will be extended until 10 weeks of gestation.",[13],"Other: Endometrial peristalsis and hormone measurements",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Endometrial peristalsis and hormone measurements","Time point for measurement of endometrial peristalsis will be assessed at three specific time points:\n\n* On the second day to the fourth day of the menstrual cycle in the FET cycles.\n* The day of progesterone initiation (before progesterone exposure)\n* On the day of embryo transfer, immediately prior to the procedure\n\nHormone measurements: serum levels of estradiol (E2) and progesterone (P4) will be assessed three times, on the same days as the endometrial peristalsis measurements, using electrochemiluminescence immunoassays. (Elecsys® Estradiol III and Elecsys® Progesterone III, Cobas® e 411, Roche Diagnostics, Germany):\n\n* On the second day to the fourth day of the menstrual cycle in the FET cycles\n* The day of progesterone initiation\n* On the transfer day prior to the procedure.",[9],[20],{"name":21,"affiliation":22,"role":23},"Lan N Vuong, MD, PhD","University of Medicine and Pharmacy at Ho Chi Minh City","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Nhi NL Ho, MD","CONTACT","+84903497611","drnhiho@gmail.com",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Vu NA Ho, MD, PhD","+84935843336","bsvu.hna@myduchospital.vn",[35],{"facility":36,"status":10,"city":37,"state":10,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"IVFMD - My Duc Hospital","Ho Chi Minh City","70000","Vietnam","VN",{"type":42,"coordinates":43},"Point",[44,45],106.62965,10.82302,{"lat":45,"lon":44},[48,49],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":31,"role":27,"phone":50,"phoneExt":10,"email":33},"+84 935843336",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100644889","endometrial-peristalsis-and-pregnancy-outcomes-in-hormone-replacement-therapy-hrt---frozen-embryo-transfer-fet-cycles-100644889",false,"NCT07675213","Endometrial Peristalsis and Pregnancy Outcomes in Hormone Replacement Therapy (HRT) - Frozen Embryo Transfer (FET) Cycles","Correlation Between Endometrial Peristalsis And Pregnancy Outcomes In Patients Undergoing Frozen Embryo Transfer With Hormone Replacement Therapy for Endometrial Preparation Protocol","CONCO","Inclusion Criteria:\n\n* Women aged 18 - 42 years old\n* Scheduled for frozen embryo transfer cycles using hormone replacement therapy protocol\n* Transferred no more than two cleavage embryos or one good-quality blastocyst or no more than two poor-quality blastocysts\n* Provision of written informed consent to participate\n\nExclusion Criteria:\n\n* Having an allergy and contraindications for exogenous hormone administration (e.g., breast cancer, thromboembolic disease)\n* Cycles with preimplantation genetic testing, oocyte donation, or in vitro maturation\n* Having untreated uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate\u002F bicornuate\u002F arcuate uterus, endometrial polyp, large leiomyoma ≥5 cm in diameter, hydrosalpinx, endometrial hyperplasia)\n* Use of uterine relaxants or intralipid infusion during the embryo transfer process\n* Use of a GnRH-agonist for downregulation within one month","FEMALE","18 Years","42 Years",{"count":65,"type":66},442,"ESTIMATED","OBSERVATIONAL","Endometrial peristalsis may influence embryo implantation and pregnancy outcomes, but its role during hormone replacement therapy (HRT)-prepared frozen embryo transfer (FET) cycles remains unclear. This prospective observational study will assess endometrial peristalsis at predefined time points during HRT-prepared FET cycles using transvaginal ultrasonography and evaluate its association with pregnancy outcomes. The study aims to clarify the clinical significance of endometrial peristalsis in HRT-prepared FET cycles and to provide evidence supporting endometrial assessment in assisted reproductive technology.",[70,71,72,73,74,75,76],"Infertility","Endometrial Peristalsis","Uterine Contraction","Endometrial Waves","Frozen Embryo Transfer (FET)","Uterine Peristalsis","Hormone Replacement Therapy (HRT)",[78,79,80,81,82],"endometrial peristalsis","uterine contractions","endometrial waves","frozen embryo transfer","artificial cycles","NOT_YET_RECRUITING","2026-06-29",{"date":86,"type":87},"2026-07-01","ACTUAL",{"date":89,"type":66},"2026-06-30",{"date":91,"type":66},"2027-12-01",{"name":5,"class":6},1]