[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100312901":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":41,"responsibleParty":122,"collaborators":125,"id":134,"slug":135,"hasResults":136,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":26,"eligibilityCriteria":140,"healthyVolunteers":136,"sex":141,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":26,"studyType":147,"phases":148,"briefSummary":150,"conditions":151,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":165},{"fullName":5,"class":6},"Sun Yat-sen University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group in endoscopic surgery","EXPERIMENTAL","Stage I patients were only treated with endoscopic surgery without additional chemotherapy. Endoscopic nasopharyngectomy included endoscopic resection , with or without posterior pedicle nasal mucoperiosteal flap resurfacing the nasopharyngeal defects.",[13],"Procedure: Endoscopic surgery",{"label":15,"type":16,"description":17,"interventionNames":18},"Group in IMRT","ACTIVE_COMPARATOR","Stage I patients were only treated with radical intensity-modulated radiotherapy without additional chemotherapy. IMRT was delivered with a dynamic multileaf intensity-modulating collimator (NOMOS, Sewickley, PA) by a slice-by-slice arc rotation approach.",[19],"Radiation: Intensity-modulated radiotherapy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Endoscopic surgery","Endoscopic nasopharyngectomy included endoscopic resection, with or without posterior pedicle nasal mucoperiosteal flap resurfacing the nasopharyngeal defects.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"RADIATION","Intensity-modulated radiotherapy","All of the patients were received irradiation by IMRT. The target volumes were delineated according to a previously described institutional treatment protocol, which is in accordance with the International Commission on Radiation Units and Measurements reports 50 and 62.",[15],[33],{"name":34,"affiliation":5,"role":35},"Ming-Yuan Chen, MD,Ph.D","STUDY_DIRECTOR",[37],{"name":34,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","86-13903052650","chmingy@mail.sysu.edu.cn",[42,67,78,89,107],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Sun Yat-sen University Cancer Center","RECRUITING","Guangzhou","Guangdong","510060","China","CN",{"type":51,"coordinates":52},"Point",[53,54],113.25,23.11667,{"lat":54,"lon":53},[57,60,62,65],{"name":58,"role":38,"phone":59,"phoneExt":26,"email":40},"Ming-Yuan Chen, Prof.","86-20-8734-3361",{"name":58,"role":61,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":63,"role":64,"phone":26,"phoneExt":26,"email":26},"Xiong Zou, PhD.","SUB_INVESTIGATOR",{"name":66,"role":64,"phone":26,"phoneExt":26,"email":26},"Rui You, PhD.",{"facility":68,"status":44,"city":45,"state":46,"zip":69,"country":48,"countryCode":49,"cosmosGeoPoint":70,"geoPoint":72,"contacts":73},"The First Affiliated Hospital, Sun Yat-Sen University","510080",{"type":51,"coordinates":71},[53,54],{"lat":54,"lon":53},[74],{"name":75,"role":38,"phone":76,"phoneExt":26,"email":77},"Wei-Ping Wen, MD, PhD","86-13802966937","wenwp@mail.sysu.edu.cn",{"facility":79,"status":44,"city":45,"state":46,"zip":80,"country":48,"countryCode":49,"cosmosGeoPoint":81,"geoPoint":83,"contacts":84},"The First People's Hospital of Foshan","528000",{"type":51,"coordinates":82},[53,54],{"lat":54,"lon":53},[85],{"name":86,"role":38,"phone":87,"phoneExt":26,"email":88},"Jun Tang, MD","86-18038860199","tjun@fsyyy.com",{"facility":90,"status":44,"city":91,"state":46,"zip":92,"country":48,"countryCode":49,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Zhongshan People's Hospital","Zhongshan","528403",{"type":51,"coordinates":94},[95,96],113.37912,22.52306,{"lat":96,"lon":95},[99,103],{"name":100,"role":38,"phone":101,"phoneExt":26,"email":102},"Feng Lei","86-13528227676","13528227676@163.com",{"name":104,"role":38,"phone":105,"phoneExt":26,"email":106},"Ming-Fang Ji","86-13532062222","jmftbh@aliyun.com",{"facility":108,"status":44,"city":109,"state":110,"zip":111,"country":48,"countryCode":49,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"The People's Hospital of Guangxi Zhuang Autonomous Region","Nanning","Guangxi","530021",{"type":51,"coordinates":113},[114,115],108.31667,22.81667,{"lat":115,"lon":114},[118],{"name":119,"role":38,"phone":120,"phoneExt":26,"email":121},"Shen-Hong Qu, MD, PhD","86-15807813816","qshdoctor@163.com",{"type":61,"investigatorFullName":123,"investigatorTitle":124,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ming-Yuan Chen","Prof.",[126,128,130,132],{"name":127,"class":6},"First Affiliated Hospital, Sun Yat-Sen University",{"name":129,"class":6},"First People's Hospital of Foshan",{"name":131,"class":6},"Zhongshan People's Hospital, Guangdong, China",{"name":133,"class":6},"People's Hospital of Guangxi Zhuang Autonomous Region","100312901","endoscopic-nasopharyngectomy-for-newly-diagnosed-stage-i-nasopharyngeal-carcinoma-patients-100312901",false,"NCT03353467","Endoscopic Nasopharyngectomy for Newly Diagnosed Stage I Nasopharyngeal Carcinoma Patients","A Prospective Clinical Trial of Endoscopic Nasopharyngectomy for Newly Diagnosed Stage I Nasopharyngeal Carcinoma Patients","Inclusion Criteria:\n\n* Previously untreated, biopsy-proven World Health Organization (WHO) types II or III NPC; Stage I disease (American Joint Committee on Cancer 7th edition); Between 18 and 70 years old; Adequate bone marrow, liver and renal function; Satisfactory performance status: a score of 0 or 1 using the Eastern Cooperative Oncology Group System; Patients provided signed informed consent.\n\nExclusion Criteria:\n\n* Evidence of relapse or distant metastasis; History of prior malignancy or previous treatment for NPC; The presence of uncontrolled life-threatening diseases; The investigator considered the patient unable to complete the study.","ALL","18 Years","70 Years",{"count":145,"type":146},228,"ESTIMATED","INTERVENTIONAL",[149],"NA","Nasopharyngeal carcinoma (NPC) is most prevalent in eastern Asia, with the highest incidence reported among the Cantonese population from the province of Guangdong. Radiotherapy is the cornerstone of initial treatment due to the radiosensitive behavior of NPC and its deep-seated location. Although radiotherapy has achieved satisfactory results, it can also cause some severe adverse events. Currently, surgery is only applied to the treatment of recurrent NPC (rNPC) patients, mainly dominated by the conventional open surgery. However, the traditional surgery was accompanied by high rate of treatment-induced complications and low rate of block removal, which greatly limited the surgical application to the treatment of primary NPC.\n\nWith the continuous improvement in surgical techniques, especially the electronic endoscopic system to be used in the surgical treatment recently, endoscopic nasopharyngectomy can largely overcome these shortcomings of traditional surgery mentioned above.\n\nIn addition, the investigators retrospectively analyzed the survival outcomes of 9 patients with NPC (all T1N0M0 according to the UICC \u002F AJCC seventh staging) treated with endoscopic nasopharyngectomy in our hospital, with 5-year rate of overall survival, loco-regional-free survival, distant metastasis-free survival of 100%. Therefore, the investigators considered endoscopic nasopharyngectomy for staged I NPC patients feasible.\n\nThis study will focus on the survival outcomes and quality of life of the staged I NPC patients treated with endoscopic nasopharyngectomy.",[152,153,154,155],"Nasopharyngeal Carcinoma","Endoscopic Surgery","Primary Napharyngeal Carcinama","Stage I Nasopharyngeal Cancer","2021-05-31",{"date":158,"type":159},"2021-06-03","ACTUAL",{"date":161,"type":159},"2017-10-01",{"date":163,"type":146},"2028-10-01",{"name":5,"class":6},5]