[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100516902":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":60,"collaborators":63,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":25,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EUS-guided rendezvous group (EUS RV group)","ACTIVE_COMPARATOR","In the EUS RV group, a linear array echoendoscope would be used to evaluate the common bile duct and left intrahepatic duct in order to identify the optimal route for biliary access by fine needle. Using a 19 gauge EUS needle, the dilated biliary tree will be accessed by either a transduodenal puncture to the common bile duct or a transgastric puncture to the left intrahepatic duct under direct EUS guidance. The optimal access route will be based on patient's anatomy after EUS assessment and left to the discretion of the investigator. Next, a guidewire would be advanced through the needle into the bile duct and out of the papillary orifice. The echoendoscope would then be exchanged to a duodenoscope for ERCP. The EUS rendezvous ERCP procedure will be completed by retrieving the rendezvous guidewire into the duodenoscope or by cannulation alongside the rendezvous guidewire to obtain biliary access.",[13],"Procedure: EUS-guided rendezvous",{"label":15,"type":10,"description":16,"interventionNames":17},"Early precut papillotomy group (EPP group)","In the EPP group, the precut papillotomy would be performed with 1 of the following acceptable techniques per the usual practice of the study investigator and institution: 1) conventional precut papillotomy by needle knife, 2) precut fistulotomy by needle knife, or 3) transpancreatic precut papillotomy by papillotome",[18],"Procedure: Early precut papillotomy group",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","EUS-guided rendezvous","A linear array echoendoscope would be used to evaluate the common bile duct and left intrahepatic duct in order to identify the optimal route for biliary access by fine needle. Using a 19 gauge EUS needle, the dilated biliary tree will be accessed by either a transduodenal puncture to the common bile duct or a transgastric puncture to the left intrahepatic duct under direct EUS guidance. The optimal access route will be based on patient's anatomy after EUS assessment and left to the discretion of the investigator. Next, a guidewire would be advanced through the needle into the bile duct and out of the papillary orifice. The echoendoscope would then be exchanged to a duodenoscope for ERCP. The EUS rendezvous ERCP procedure will be completed by retrieving the rendezvous guidewire into the duodenoscope or by cannulation alongside the rendezvous guidewire to obtain biliary access.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Early precut papillotomy group","The precut papillotomy would be performed with 1 of the following acceptable techniques per the usual practice of the study investigator and institution: 1) conventional precut papillotomy by needle knife, 2) precut fistulotomy by needle knife, or 3) transpancreatic precut papillotomy by papillotome",[15],[31],{"name":32,"affiliation":5,"role":33},"Raymond Tang, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Felix Sia","CONTACT","26370428","felixsia@cuhk.edu.hk",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Prince of Wales Hospital, The Chinese University of Hong Kong","RECRUITING","Shatin","New Territories","Hong Kong","HK",{"type":49,"coordinates":50},"Point",[51,52],114.18333,22.38333,{"lat":52,"lon":51},[55,58],{"name":56,"role":37,"phone":57,"phoneExt":25,"email":39},"Felix Sia, BS","(852) 26370428",{"name":59,"role":33,"phone":25,"phoneExt":25,"email":25},"Raymond S Tang, MD",{"type":33,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Raymond Shing Yan Tang","Assitant Professor",[64,66],{"name":65,"class":6},"Tokyo University",{"name":67,"class":6},"Gifu University Graduate School of Medicine","100516902","endoscopic-ultrasound-guided-rendezvous-versus-precut-papillotomy-100516902",false,"NCT06010576","Endoscopic Ultrasound-guided Rendezvous Versus Precut Papillotomy","Endoscopic Ultrasound-guided Rendezvous Technique Versus Early Precut Papillotomy for Difficult Bile Duct Cannulation During Endoscopic Retrograde Cholangiopancreatography: a Multicenter Randomized Controlled Trial","ERVPP","Inclusion Criteria:\n\n* Patients age 18 years or older undergoing ERCP with indication for bile duct cannulation\n* Native major papilla\n* Difficult bile duct cannulation, defined by the presence of 1 of the following: 1) unsuccessful bile duct cannulation within 10 cannulation attempts, 2) unsuccessful bile duct cannulation within 10 minutes spent in cannulation, or 3) 2 unintended pancreatic duct cannulation or opacification with contrast\n* Written informed consent available\n\nExclusion Criteria:\n\n* Unable to provide written informed consent\n* Contraindications for endoscopy due to comorbidities\n* Prior biliary sphincterotomy\n* Surgically altered upper gastrointestinal anatomy or duodenal obstruction precluding a standard ERCP\n* Uncorrectable coagulopathy (INR \\> 1.5) and thrombocytopenia (platelet \\\u003C 50,000) by blood product transfusion\n* Pregnant patients","ALL","18 Years",{"count":79,"type":80},188,"ESTIMATED","INTERVENTIONAL",[83],"NA","Selective bile duct cannulation is the most important step in endoscopic retrograde cholangiopancreatography (ERCP) for treatment of benign and malignant pancreatobiliary diseases, but it may fail in up to 15% of cases. Precut papillotomy is an advanced ERCP cannulation technique recommended by guidelines for rescue of difficult biliary access, but it is not without limitations. Endoscopic ultrasound (EUS)-guided biliary drainage is a novel interventional EUS technique that has been increasingly performed after failed biliary access by advanced ERCP cannulation techniques.",[86],"Bile Duct Diseases",[88],"ERCP, EUS","2026-02-17",{"date":91,"type":92},"2026-02-19","ACTUAL",{"date":94,"type":92},"2023-09-05",{"date":96,"type":80},"2027-06-30",{"name":5,"class":6},1]