[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637699":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":44,"collaborators":19,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":19,"enrollmentInfo":56,"targetDuration":19,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":19,"overallStatus":29,"whyStopped":19,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"European Institute of Oncology","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Endoscopic video-assisted nipple-sparing mastectomy (E-NSM)","EXPERIMENTAL","All enrolled patients will undergo endoscopic video-assisted nipple-sparing mastectomy (E-NSM) with immediate breast reconstruction (implant-based or pre-planned alternative reconstruction).",[13],"Procedure: Endoscopic video-assisted nipple-sparing mastectomy (E-NSM)",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"PROCEDURE","Endoscopic video-assisted nipple-sparing mastectomy (E-NSM) is an advancement in minimally invasive breast surgery designed to reduce surgical trauma and improve cosmetic outcomes while maintaining strict oncologic safety. Recent prospective studies and meta-analyses have shown encouraging results in terms of technical feasibility, reduced flap-related complications, and higher patient satisfaction compared with the conventional open approach.",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Eleonora Meduri, MD","CONTACT","+39 02 57489 725","eleonora.meduri@ieo.it",[27],{"facility":28,"status":29,"city":30,"state":19,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Istituto Europeo di Oncologia","RECRUITING","Milan","20141","Italy","IT",{"type":35,"coordinates":36},"Point",[37,38],12.59836,42.78235,{"lat":38,"lon":37},[41,42],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},{"name":22,"role":43,"phone":19,"phoneExt":19,"email":19},"PRINCIPAL_INVESTIGATOR",{"type":45,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100637699","endoscopic-video-assisted-nipple-sparing-mastectomy-100637699",false,"NCT07579117","Endoscopic Video-Assisted Nipple-Sparing Mastectomy","EVA - Endoscopic Video-Assisted Nipple-Sparing Mastectomy (E-NSM): A Pilot Study","EVA","Inclusion Criteria:\n\n* Female patients aged ≥18 years\n* Candidates for nipple-sparing mastectomy (NSM) with immediate reconstruction\n* Histologically confirmed invasive carcinoma cT1N0, or carriers of pathogenic germline mutations undergoing prophylactic mastectomy\n* Breast size I-III and absence of significant glandular ptosis\n* Signed informed consent\n\nExclusion Criteria:\n\n* Inflammatory breast cancer\n* Locally advanced clinical stage (cT2-T4 or N+)\n* Ductal carcinoma in situ (DCIS) without invasive component\n* Previous radiotherapy to the affected breast\n* Locoregional recurrence\n* Clinical conditions contraindicating prosthetic reconstruction\n* Indication for skin-sparing (SSM) or skin-reducing mastectomy (SRM)\n* Ongoing or completed neoadjuvant chemotherapy before surgery\n* Refusal or inability to sign informed consent\n* Inability to complete scheduled follow-up","FEMALE","18 Years",{"count":57,"type":58},10,"ESTIMATED","INTERVENTIONAL",[61],"NA","Endoscopic video-assisted nipple-sparing mastectomy (E-NSM) is an advancement in minimally invasive breast surgery designed to reduce surgical trauma and improve cosmetic outcomes while maintaining strict oncologic safety. The procedure will be carried out by a dedicated surgical team in which at least one operator holds certified laparoscopic surgical training issued by a recognized scientific society, ensuring appropriate technical expertise and adherence to surgical safety standards.",[64,65,66],"Endoscopic Video-assisted Nipple-sparing Mastectomy","Breast Surgery","Breast Cancer","2026-05-28",{"date":69,"type":70},"2026-06-01","ACTUAL",{"date":72,"type":70},"2026-05-23",{"date":74,"type":58},"2027-07",{"name":5,"class":6},1]