[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620468":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":34,"locations":41,"responsibleParty":57,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":10,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"von willebrand disease\u002F Acquired von Willebrand disease patients",null,"Patients with a confirmed diagnosis of VWD or AVWS. Participants will undergo peripheral blood sample collection for plasma VWF measurements and ECFCs isolation and characterization. In patients with VWD without prior molecular characterization, an additional blood sample will be collected for genetic analysis.",[13,14,15],"Diagnostic Test: Blood sample collection for VWF measurements in plasma","Other: Blood sample collection for ECFC isolation and characterization","Other: Genetic testing of VWF",{"label":17,"type":10,"description":18,"interventionNames":19},"Healthy donors","Healthy volunteers with no personal or family history of bleeding or thrombotic disorders, serving as the reference population for the study. Participants will undergo peripheral blood sample collection plasma VWF measurements and ECFCs isolation and characterization.",[13,14],[21,26,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DIAGNOSTIC_TEST","Blood sample collection for VWF measurements in plasma","Plasma samples will be collected for the measurement of VWF levels.",[17,9],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Blood sample collection for ECFC isolation and characterization","Blood samples will be collected to isolate ECFCs and perform their subsequent characterization.",[17,9],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Genetic testing of VWF","An additional blood sample will be collected for VWF genetic testing in patients with VWD without prior molecular characterization.",[9],[35],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Flora Peyvandi, MD, PhD","CONTACT","02-55035414","+39","flora.peyvandi@policlinico.mi.it",[42],{"facility":43,"status":44,"city":45,"state":10,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, A.B.Bonomi Hemophilia and Thrombosis Center","RECRUITING","Milan","20122","Italy","IT",{"type":50,"coordinates":51},"Point",[52,53],9.18951,45.46427,{"lat":53,"lon":52},[56],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},{"type":58,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100620468","endothelial-colony-forming-cells-in-patients-with-vwd-avws-and-healthy-subjects-100620468",false,"NCT07358013","Endothelial Colony-Forming Cells in Patients With VWD, AVWS and Healthy Subjects","Isolation and Characterization of Endothelial Colony Forming Cells (ECFCs) in Patients Diagnosed With Von Willebrand Disease, Acquired Von Willebrand Syndrome and Healthy Subjects","ECFCs\u002F2022","Inclusion Criteria for patients:\n\nPatients with von Willebrand disease (VWD) or acquired von Willebrand syndrome (AVWS)\n\nAge ≥ 16 years.\n\nPrevious diagnosis of von Willebrand disease or acquired von Willebrand syndrome, defined as one of the following:\n\nGroup A - Type 1 VWD:\n\nVWF levels ≤ 30 IU\u002FdL, regardless of bleeding history, or\n\nVWF levels ≤ 0.50 IU\u002FmL in the presence of abnormal bleeding.\n\nGroup B - Congenital or acquired VWD (VWD or AVWS):\n\nDiagnosis of congenital or acquired VWD, with or without gastrointestinal bleeding.\n\nGroup C - Subgroup study (Type 2A VWD):\n\nOne patient with type 2A VWD selected for a dedicated sub-study involving allele-specific siRNA silencing of the mutant allele.\n\nAbility and willingness to provide written informed consent.\n\nFor patients without prior molecular characterization: willingness to undergo VWF gene sequencing and to sign the related informed consent.\n\nInclusion criteria for healthy volunteers\n\n* No prior diagnosis of VWD, bleeding disorders, or thrombotic disorders.\n* Willingness to donate blood for study procedures.\n* Ability and willingness to provide written informed consent.\n* Age ≥ 18 years.\n\nExclusion criteria for both patients and healthy volunteers:\n\n* Pregnancy.\n* Anemia, as determined at screening or based on medical history.",true,"ALL","16 Years",{"count":71,"type":72},48,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how endothelial colony-forming cells (ECFCs) behave in people with von Willebrand disease (VWD), acquired von Willebrand syndrome (AVWS), and in healthy individuals.",[76,77],"Von Willebrand Disease (VWD)","Acquired Von Willebrand Disease",[79,80,81,82],"von Willebrand disease","von Willebrand factor","ex vivo","endothelial colony forming cells (ECFCs)","2026-01-13",{"date":85,"type":86},"2026-01-22","ACTUAL",{"date":88,"type":86},"2023-11-11",{"date":90,"type":72},"2028-05-31",{"name":5,"class":6},1]