[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525269":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":17,"responsibleParty":34,"collaborators":7,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":7,"studyType":50,"phases":7,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":20,"whyStopped":7,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Istituto Ortopedico Rizzoli","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Sandra Giannone, MD","PRINCIPAL_INVESTIGATOR",[13],{"name":10,"role":14,"phone":15,"phoneExt":7,"email":16},"CONTACT","+393203382071","sandra.giannone@gmail.com",[18],{"facility":19,"status":20,"city":21,"state":22,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Sandra Giannone","RECRUITING","Bologna","BO","40128","Italy","IT",{"type":27,"coordinates":28},"Point",[29,30],11.33875,44.49381,{"lat":30,"lon":29},[33],{"name":19,"role":14,"phone":7,"phoneExt":7,"email":16},{"type":35,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100525269","endothelial-damage-in-major-spine-surgery-measured-by-circulating-syndecan-1-an-observational-studyglycortho-100525269",false,"NCT06119542","Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)","Endothelial Glycocalyx Damage in Major Spine Surgery, as Measured by Circulating Syndecan-1 Levels: a Prospective Observational Pilot Study.(GlycOrtho)","GlycOrtho","Inclusion Criteria:\n\n* Undergoing Major Spine Surgery with estimated blood loss\\> 25% of total blood volume\n* American Society of Anesthesiology status 1-2-3\n* Able to comprehend and sign informed consent.\n* If age \\\u003C18 years: parent or legal representative able to comprehend and sign informed consent\n\nExclusion Criteria:\n\n* Surgery outside of laboratory opening hours\n* Patients undergoing spine surgery for genetic syndromes\u002Fneuromuscular scoliosis","ALL","12 Years","75 Years",{"count":48,"type":49},30,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about endothelial damage in major spine surgery, expressed as rise in circulating Syndecan-1.\n\nThe main questions it aims to answer are:\n\n* What is the extent of endothelial glycocalyx shedding in major spine surgery?\n* Are there differences in different type of surgical populations? (adolescent idiopathic scoliosis, adult degenerative spine disease, oncologic surgery)\n\nTo do so, blood samples will be drawn from participants at the following timepoints:\n\n* basal\n* after surgery\n* if transfusion of Fresh Frozen Plasma: before and after transfusion\n* Post-Operative Day 1-2-4",[53],"Spinal Fusion",[55,56,57,58],"Endothelium","Syndecan-1","Surgery","Glycocalyx","2026-05-20",{"date":61,"type":62},"2026-05-22","ACTUAL",{"date":64,"type":62},"2026-02-28",{"date":66,"type":49},"2026-09-30",{"name":5,"class":6},1]