[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586215":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":37,"centralContacts":42,"locations":48,"responsibleParty":68,"collaborators":10,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":10,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Heidelberg University","OTHER",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Preeclampsia",null,"patients with diagnosis of preeclampsia according to definitions by the International Society for the Study of Hypertension in Pregnancy (n=110)",[13,14],"Diagnostic Test: Hyperspectral imaging","Diagnostic Test: Further markers of endothelial dysfunction",{"label":16,"type":10,"description":17,"interventionNames":18},"Pregnancy induced Hypertension and chronic Hypertension","patients with hypertension in pregnancy without fulfilling criteria of preeclampsia (n=110)",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Normotensive pregnant control group","normotensive pregnancies (n=110)",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Non-pregnant control group","normotensive, non-pregnant women (n=55)",[13,14],[28,33],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"DIAGNOSTIC_TEST","Hyperspectral imaging","Hyperspectral imaging will be performed at study inclusion and will be repeated longitudinally every 1-2 days until delivery and on the first and second day after delivery. After a baseline measurement, a blood pressure cuff is inflated on the upper arm to 50 mmHg above the systolic blood pressure for 5 minutes, and then the hyperspectral imaging measurement is repeated.\n\nBlood samples are collected at study inclusion and on the first and second day after delivery and are processed within the Department of Gynecology and Obstetrics of the Heidelberg University Hospital.",[24,20,9,16],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":10},"Further markers of endothelial dysfunction","At study inclusion: 1. blood samples will be collected for the measurement of EASIX and cardiac\u002Fendothelial markers; 2. sublingual in vivo microscopy will be performed (requires about 20 minutes and can be compared to a sublingual temperature measurement); 3. Doppler ultrasound will be performed to evaluate uterine and ophthalmic arteries.\n\nBlood samples will also be collected at the first and second day after delivery.",[24,20,9,16],[38],{"name":39,"affiliation":40,"role":41},"Dr. med. Alexandra von Au","University Heidelberg","PRINCIPAL_INVESTIGATOR",[43],{"name":44,"role":45,"phone":46,"phoneExt":10,"email":47},"Dr. med. Anna Scholz","CONTACT","+49 6221 56 32080","anna.scholz@med.uni-heidelberg.de",[49],{"facility":50,"status":51,"city":52,"state":10,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Heidelberg University Hospital, Department of Gynecology and Obstetrics","RECRUITING","Heidelberg","69120","Germany","DE",{"type":57,"coordinates":58},"Point",[59,60],8.69079,49.40768,{"lat":60,"lon":59},[63,64,67],{"name":44,"role":45,"phone":46,"phoneExt":10,"email":47},{"name":65,"role":45,"phone":10,"phoneExt":10,"email":66},"Alexandra von Au, Dr. med.","alexandra.vonau@med.uni-heidelberg.de",{"name":65,"role":41,"phone":10,"phoneExt":10,"email":10},{"type":41,"investigatorFullName":69,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Anna Scholz","100586215","endothelial-dysfunction-for-prognosis-in-patients-with-preeclampsia-100586215",false,"NCT06912477","Endothelial Dysfunction for Prognosis In Patients With preeClampSia","Systematic Evaluation of Endothelial Dysfunction as a Prognostic Marker for Outcomes in Women With Preeclampsia","EPICS","Inclusion Criteria:\n\n* singleton pregnancies\n* Age ≥ 18 years\n* Patient's ability to provide consent\n* written informed consent\n\nExclusion Criteria:\n\n* Lack of consent\n* Language barrier\n* Dark to very dark skin type\n* Severe fetal chromosomal\u002Fgenetic\u002Fstructural anomalies\n* Laboratory changes in LDH, creatinine, or platelets due to other causes (e.g., isolated thrombocytopenia, e.g., immune thrombocytopenia, carcinoma)",true,"FEMALE","18 Years",{"count":82,"type":83},385,"ESTIMATED","OBSERVATIONAL","Preeclampsia is a pregnancy-specific hypertensive disorder and can progress rapidly to severe adverse outcomes affecting both the mother and the fetus. Endothelial and microcirculatory dysfunction mediate systemic preeclampsia-related organ dysfunctions. Changes in endothelial and vascular function in preeclampsia have been demonstrated through reduced flow-mediated vasodilation as a result of reduced availability of nitric oxide, which potentially persists up to several years postpartum. Hyperspectral imaging is a new innovative technology that allows to assess the peripheral microcirculation and perfusion non-invasively and contactless, but has never been evaluated in the context of preeclampsia before.\n\nThis EPICS project (Endothelial dysfunction for Prognosis In patients with preeClampSia) is a prospective observational study and aims to investigate hyperspectral imaging as a new potential diagnostic and prognostic marker in preeclampsia.",[87,88],"Preeclampsia (PE)","Hypertensive Disorder of Pregnancy",[90,91,92],"preeclampsia","hyperspectral imaging","endothelial dysfunction","2025-05-08",{"date":95,"type":96},"2025-05-11","ACTUAL",{"date":93,"type":96},{"date":99,"type":83},"2027-07",{"name":5,"class":6},1]