[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100486057":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":40,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":10,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":10,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},{"fullName":5,"class":6},"University Hospital Hradec Kralove","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Brain dead organ donors",null,"Patients with clinically proven bain death were assigned to the paraclinical confirmatory investigation of the brain death and subsequently accepted into the transplantation program.",[13],"Diagnostic Test: Endothelial glycocalyx damage assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Endothelial glycocalyx damage assessment","Degradation products of endothelial glycocalyx will be assessed in the blood and urine.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"David Astapenko, MD, PhD","CONTACT","+420495833218","david.astapenko@fnhk.cz",[27],{"facility":5,"status":28,"city":29,"state":10,"zip":30,"country":31,"countryCode":10,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"RECRUITING","Hradec Králové","50005","Czechia",{"type":33,"coordinates":34},"Point",[35,36],15.83277,50.20923,{"lat":36,"lon":35},[39],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","David Astapenko, MD, PhD, MBA","Deputy Head for Science and Research","100486057","endothelial-glycocalyx-damage-in-brain-death-organ-donors-100486057",false,"NCT05609123","Endothelial Glycocalyx Damage in Brain Death Organ Donors","Endothelial Glycocalyx Status and Damage in Brain Death Organ Donors","Inclusion Criteria:\n\n* patients in critical condition declared as brain dead by clinical examination\n\nExclusion Criteria:\n\n* N\u002FA","ALL","18 Years",{"count":54,"type":55},100,"ESTIMATED","OBSERVATIONAL","The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.",[59,60,61],"Brain Damage Due to Hypoxia","Organ Donors","Organ Transplant Failure or Rejection","2026-04-27",{"date":64,"type":65},"2026-05-01","ACTUAL",{"date":67,"type":65},"2022-01-01",{"date":69,"type":55},"2027-12-31",{"name":5,"class":6},1]