[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602946":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":44,"responsibleParty":61,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":26,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":86,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Centre Hospitalier Régional d'Orléans","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Suctionning Extubation (experimental arm)","EXPERIMENTAL","Endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients in the intensive care unit.",[13],"Procedure: Suctionning extubation",{"label":15,"type":16,"description":17,"interventionNames":18},"No Suctionning Extubation (control arm)","SHAM_COMPARATOR","No endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients in the intensive care unit.",[19],"Procedure: No suctionning Extubation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Suctionning extubation","We will remove the intubation tube with endotracheal suctioning during the extubation procedure and maintain positive end expiratory pressure (PEEP) and pressure support. The PEEP level will be 10 cmH2O and the pressure support 7 cmH2O for 2 minutes prior to extubation. The vacuum level will be the maximum level (standard procedure in the unit), i.e. 450 mmHg. The closed-system suction probe is inserted up to the last mark corresponding to 40cm. The size of our closed system is identical for all patients, i.e. 14 french.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"No suctionning Extubation","In the control group, removal of the intubation tube during the extubation procedure is performed with PEEP maintained, without endotracheal suctioning. The PEEP level will be set at 10 cmH2O and the pressure at 7 cmH2O in the 2 minutes prior to extubation.",[15],[32],{"name":33,"affiliation":34,"role":35},"Cécile FOSSAT","Centre Hospitalier Universitaire d'Orléans","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+33238575252","fanny.louat@chu-orleans.fr",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":40},"Fanny LOUAT","+33238744295",[45],{"facility":34,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Orléans","Loiret","45067","France","FR",{"type":53,"coordinates":54},"Point",[55,56],1.90407,47.90248,{"lat":56,"lon":55},[59],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":60},"cecile.fossat@chu-orleans.fr",{"type":62,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100602946","endotracheal-suctionning-during-positive-pressure-extubation-in-icu-100602946",false,"NCT07130123","Endotracheal Suctionning During Positive Pressure Extubation in ICU","Removal of the Intubation Tube Under Positive Pressure With or Without Endotracheal Suctioning During Extubation in Intensive Care: a Prospective Randomised Controlled Trial","INTENTION","Inclusion Criteria:\n\n* Adult patient\n* Intubated for more than 48 hours\n* Patient for whom extubation is prescribed by the patient's physician\n\nExclusion Criteria:\n\n* Headboard restriction\\>30°.\n* Decision to limit active treatment in advance of reintubation\n* Protected person (under guardianship or curatorship)\n* Person under court protection\n* Persons deprived of liberty\n* Persons not affiliated to a social security scheme\n* Pregnant or breast-feeding woman\n* No co-inclusion with a study whose period of interest is follow-up within 3 hours of extubation.","ALL","18 Years",{"count":74,"type":75},120,"ESTIMATED","INTERVENTIONAL",[78],"NA","The aim of this clinical trial is to evaluate endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients (over 18 years old) in the intensive care unit (ICU). The main question it aims to answer is whether the intervention improves the respiratory oxygenation index (ROX) three hours after extubation compared to no endotracheal suction during positive pressure extubation.\n\nParticipants will only need to be extubated by the nursing team in the ICU. Follow-up will consist of evaluating respiratory rate, pulse oximetry and inspired oxygen fraction for three hours following extubation.",[81,82,83,84,85],"Mechanical Ventilation With Oral Intubation","Weaning Invasive Mechanical Ventilation","Oxygen Saturation Measurement","Rox Index","Extubation",[87,88,89],"rox index","extubation","Suctionning","2025-12-12",{"date":92,"type":93},"2025-12-19","ACTUAL",{"date":95,"type":93},"2025-10-03",{"date":97,"type":75},"2027-10",{"name":5,"class":6},1]