[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100450821":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":22,"responsibleParty":39,"collaborators":10,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":54,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Evangelismos Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with de novo acute hypoxemic respiratory failure",null,"We will consider for inclusion patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF). De novo AHRF is defined as the requirement of oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more in a patient who does not receive long term oxygen therapy.",[13],{"name":14,"affiliation":5,"role":15},"Ilias I. Siempos, MD, DSc","PRINCIPAL_INVESTIGATOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Eleni D. Papoutsi, MD","CONTACT","+306981173761","helenapapoutsi@gmail.com",[23],{"facility":5,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"RECRUITING","Athens","Attica","10676","Greece","GR",{"type":31,"coordinates":32},"Point",[33,34],23.72784,37.98376,{"lat":34,"lon":33},[37],{"name":38,"role":19,"phone":10,"phoneExt":10,"email":10},"Eleni Papoutsi, MD",{"type":15,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ilias Siempos","Assistant Professor in Critical Care and Pulmonary Medicine","100450821","endotyping-prehospital-de-novo-acute-hypoxemic-respiratory-failure-100450821",false,"NCT05150483","EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure","EPIPHANY","Inclusion Criteria:\n\n* Adult patients (aged \\>18 years) presenting in the emergency department\n* De novo acute hypoxemic respiratory failure (requiring oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more)\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Not admitted to the hospital\n* Postoperative acute respiratory failure (within one week from surgery)\n* Chronic hypoxemic respiratory failure (requiring long term oxygen therapy at home)\n* Hypercapnic respiratory failure\n* Transferred from another hospital or facility\n* Pregnant women\n* Admitted to the hospital purely to facilitate comfort care\n* Lack of informed consent","ALL","18 Years",{"count":52,"type":53},250,"ESTIMATED","28 Days","OBSERVATIONAL","We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF). We also attempt to identify what clinical, radiological, physiological and biological variables collected early in the course of AHRF correlate with subsequent mortality and\u002For persistent severe hypoxemia.",[58,59],"Acute Hypoxemic Respiratory Failure","Acute Respiratory Distress Syndrome",[61,62,63,64,65,66,67],"critical illness","intensive care unit","endotypes","phenotypes","emergency department","trajectory","mechanical ventilation","2025-08-04",{"date":70,"type":71},"2025-08-07","ACTUAL",{"date":73,"type":71},"2021-12-10",{"date":75,"type":53},"2026-04-30",{"name":5,"class":6},1]