[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626860":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":43,"centralContacts":43,"locations":44,"responsibleParty":62,"collaborators":43,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":43,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":43,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":93,"whyStopped":43,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Texas at Austin","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Behavior-based Attention control with Meditation","ACTIVE_COMPARATOR","Subjects complete an nback task after a meditation intervention in which ground truth visual feedback is provided at the end of each run.",[13],"Behavioral: Mindfulness Meditation",{"label":15,"type":10,"description":16,"interventionNames":17},"Behavior-based Attention control with Open-Loop tACS","Subjects complete an nback task after a tACS intervention in which ground truth visual feedback is provided at the end of each run.",[18],"Device: transcranial electrical stimulation",{"label":20,"type":21,"description":22,"interventionNames":23},"EEG-based Attention Control and Meditation","EXPERIMENTAL","Subjects complete an nback task in which EEG-based visual feedback is provided after each trial",[13],{"label":25,"type":21,"description":22,"interventionNames":26},"EEG-Based Attention Control and Open-Loop tACS",[18],[28,35],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DEVICE","transcranial electrical stimulation","tACS is delivered as a pre-task neuromodulatory intervention intended to prime neural activity before cognitive assessment.\n\nElectroencephalography (EEG) signals will be recorded from subjects as they perform nback tasks. The neural correlates of attention will be processed and decoded in real-time using machine learning algorithms to provide feedback. Subjects are instructed to assume a mental state\u002Ffind a strategy to maximise the accuracy of feedback. In total, each subject will complete 5 sessions of nback training with this intervention.",[15,25],[34],"tACS",{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"BEHAVIORAL","Mindfulness Meditation","A relaxation protocol based on mindfulness meditation will be carried out. This consists of closing the eyes and focusing on breathing and relaxing for a period of 5 minutes.\n\nElectroencephalography (EEG) signals will be recorded from subjects as they perform nback tasks. The neural correlates of attention will be processed and decoded in real-time using machine learning algorithms to provide feedback. Subjects are instructed to assume a mental state\u002Ffind a strategy to maximise the accuracy of feedback. In total, each subject will complete 5 sessions of nback training with this intervention",[9,20],[41,42],"Relaxation","Meditation",null,[45],{"facility":46,"status":43,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Engineering Education and Research Center","Austin","Texas","78712","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-97.74306,30.26715,{"lat":56,"lon":55},[59],{"name":60,"role":61,"phone":43,"phoneExt":43,"email":43},"José del.R Millan, PhD","PRINCIPAL_INVESTIGATOR",{"type":61,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Jose del R. Millan","Principal Investigator","100626860","enhancing-attention-in-elderly-using-a-brain-computer-interface-100626860",false,"NCT07441122","Enhancing Attention in Elderly Using a Brain-Computer-Interface","Building Cognitive Reserve Through Brain-Computer-Interfaces","Inclusion Criteria:\n\nYounger adults:\n\n* Good general health.\n* Normal or corrected vision.\n* no history of neurological\u002Fpsychiatric disease\n* ability to read and understand English\n* ability to understand information and ability to give a free and informed consent\n\nOlder adults:\n\n* Normal or corrected vision.\n* Self-reports no current diagnosis of dementia.\n* Ability to provide written\u002Felectronic, informed consent.\n\nExclusion Criteria:\n\nYounger Adults:\n\n* Neurological or psychiatric diseases that could be contraindicated for tACS (e.g., personal history of epilepsy\u002Fseizure brain damage, history of fainting, bipolar disorder, schizophrenia, current substance use disorder, etc.).\n* Medications that elevate seizure threshold (e.g., stimulant medication, high dose bupropion).\n* Factors hindering EEG acquisition and tACS delivery (e.g., skin infection, wounds, dermatitis, inability to access the scalp of the participant).\n\nOlder Adults:\n\n* Neurological or psychiatric diseases that could be contraindicated for tACS (e.g., personal history of epilepsy\u002Fseizure brain damage, pacemakers, history of fainting, bipolar disorder, schizophrenia, current substance use disorder, etc.).\n* Medications that elevate seizure threshold (e.g., stimulant medication, high dose bupropion).\n* Factors hindering EEG acquisition and tACS delivery (e.g., skin infection, wounds, dermatitis, inability to access the scalp of the participant).\n* Diagnosis of dementia.\n* Do not have the capacity to provide informed consent.",true,"ALL","18 Years","90 Years",{"count":77,"type":78},100,"ESTIMATED","INTERVENTIONAL",[81],"NA","Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology. Enhancing cognitive reserve is thought to delay cognitive decline and improve functional outcomes in aging and neurodegenerative conditions. Attention and memory-related neural processes are considered key contributors to cognitive reserve, yet it remains unclear whether these neural markers can be deliberately strengthened through targeted training and non-invasive interventions.\n\nThe goal of this clinical study is to investigate whether mindfulness-based meditation and non-invasive brain stimulation can enhance neural markers of attention and memory that serve as proxies for cognitive reserve in cognitively healthy adults and older adults diagnosed with mild cognitive impairment (MCI). Investigators hypothesize that strengthening these neural markers will lead to measurable improvements in cognitive reserve-related functions in both healthy aging and MCI populations.\n\nThis study further hypothesizes that neural markers of attention can be selectively enhanced using an electroencephalography (EEG)-based brain-computer interface (BCI) combined with non-invasive interventions such as mindfulness-based relaxation or neuromodulation. During the study, participants will perform a computerized memory task while their EEG signals are recorded in real time. A BCI will analyze these signals to decode the presence or absence of the P300 event-related potential, a well-established neural marker of attentional control and cognitive resource allocation. Real-time feedback and intervention will be used to modulate these neural processes with the goal of promoting adaptive changes in attention-related brain activity.\n\nBy integrating EEG-based decoding, behavioral training, and non-invasive interventions, this study aims to determine whether targeted modulation of attention-related neural activity can support cognitive reserve in aging and mild cognitive impairment.",[84],"Mild Cognitive Impairment (MCI)",[86,87,88,89,90,91,92],"MCI","Memory","Cognitive Decline","Older Adults","Memory Impairment","Cognitive Control","Attention","NOT_YET_RECRUITING","2026-06-05",{"date":96,"type":97},"2026-06-09","ACTUAL",{"date":99,"type":78},"2026-09-01",{"date":101,"type":78},"2029-02-01",{"name":5,"class":6},1]