[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582647":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":31,"responsibleParty":49,"collaborators":26,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":26,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":34,"whyStopped":26,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Electronic Science and Technology of China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"fNIRS neurofeedback training group","EXPERIMENTAL","Individuals in the fNIRS training group will receive feedback based on their real-time brain activity in the target region and learn to upregulate PFC activity while reappraising negative images.",[13],"Device: Real-time fNIRS neurofeedback from Turbo-Satori",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham training group","SHAM_COMPARATOR","Individuals in the sham training group will receive yoked feedback from previous data acquired from another individual in real neurofeedback group while reappraising negative images.",[19],"Device: Yoked sham feedback from Turbo-Satori",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Real-time fNIRS neurofeedback from Turbo-Satori","Activity in the target brain region measured by fNIRS in real-time will undergo processing on Turbo-Satori (BrainVoyager; Maastricht, Netherlands) to infer changes in oxygenated blood activity in the target brain region and relayed to the task program for visual feedback.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Yoked sham feedback from Turbo-Satori","Previous data acquired from another individual in the experimental group will be loaded into Turbo-Satori (BrainVoyager; Maastricht, Netherlands) software for preprocessing in real-time and relayed to the task program for visual feedback.",[15],[32],{"facility":33,"status":34,"city":35,"state":26,"zip":26,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"The Hong Kong Jockey Club Building For Interdisciplinary Research, 5 Sassoon Rd, Sandy Bay","RECRUITING","Hong Kong","HK",{"type":38,"coordinates":39},"Point",[40,41],114.17469,22.27832,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":47,"phoneExt":26,"email":48},"Michelle Tsang","CONTACT","+852 3917 7126","ncam@hku.hk",{"type":50,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100582647","enhancing-emotion-regulation-through-functional-near-infrared-spectroscopy-fnirs-informed-real-time-neurofeedback-100582647",false,"NCT06866028","Enhancing Emotion Regulation Through Functional Near-infrared Spectroscopy (fNIRS)-Informed Real-time Neurofeedback","Enhancing Emotion Regulation Through fNIRS-informed Real-time Neurofeedback","Inclusion Criteria:\n\n* Normal\u002Fcorrected-to-normal vision\n* Right-handed\n* Below the cut-off for clinically-significant levels of depression (below 29) indicated by the Beck Depression Inventory (BDI-II; Beck et al., 1996)\n\nExclusion Criteria:\n\n* Current\u002Fhistory of mental health conditions\n* Current\u002Fhistory of chronic pain\n* The following conditions: Cardiovascular disorder, Raynaud's phenomenon, fainting, seizure, wounds on the hand\u002Farm\n* Frequent use of alcohol\u002Fnicotine",true,"ALL","18 Years","30 Years",{"count":63,"type":64},50,"ESTIMATED","INTERVENTIONAL",[67],"NA","The present study aims to employ real-time functional near-infrared spectroscopy (fNIRS) neurofeedback training in combination with cognitive reappraisal strategies for regulating negative emotions in healthy individuals.\n\nParticipants will complete:\n\n* Cognitive reappraisal training with either real neurofeedback or sham feedback.\n* Questionnaires at pre- and post- training timepoints\n* A cold-pressor test at the end of the training\n\nIt is hypothesized that combining real-time fNIRS neurofeedback and cognitive reappraisal training will enhance emotion regulation in healthy individuals:\n\n1. Increased neural activity in the prefrontal cortex (PFC) region of the brain will be significantly higher in the real neurofeedback group after training compared to the sham feedback group.\n2. Real-time fNIRS-guided upregulation of the PFC will enhance emotion regulation during exposure to negative stimuli\u002Fscenes across the training runs.\n3. The effects of fNIRS neurofeedback training will extend to influence emotion regulation in a cold-pressor test administered post-training, wherein individuals in the real neurofeedback group demonstrate better regulation of stress and pain induced by the task.",[70,71,72],"Neurofeedback","Emotion Regulation","Stress",[74,75,76],"fNIRS","emotion","neurofeedback","2025-03-24",{"date":79,"type":80},"2025-03-27","ACTUAL",{"date":82,"type":80},"2024-08-08",{"date":84,"type":64},"2026-08-07",{"name":5,"class":6},1]