[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632439":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":25,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"The Hong Kong Polytechnic University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Aerobic and resistance training","EXPERIMENTAL","Participants will complete two aerobic training sessions and two resistance training sessions per week for a total of four exercise training sessions each week lasting for 3-month (i.e., 13-weeks). Aerobic exercise intensity will be tracked through heart-rate monitors with an age-specific targeted heart-rate-reserve initially set at 50% and progressively increased by 5% weekly until 70% heart-rate-reserve is reached in Week-5, then it will be sustained for the remainder of the trial. The first four weeks of the resistance training program will emphasize on assisting the study participants in gaining familiarity with proper technique. The intensity of the resistance training stimulus will be set to a weight where the participants can complete two sets of 10-15 repetitions, then progressed from 45% to 85% of predicted 1-repetition-maximum determined at Week-4 using the 8-rep maximum test. The 8-rep maximum test is rrepeated every 4 weeks to ensure the exercise intensity is maintained",[13],"Behavioral: Aerobic and resistance training",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual care","PLACEBO_COMPARATOR","Participant Retention and Care: Investigator will implement strategies to promote participant retention by: (1) conducting monthly phone calls by the project assistant to encourage and motivate participants to stay within the study; (2) discussing participant barriers\u002Fdistress and developing coping\u002Faction plans; (3) providing monthly updates in the form of in-person\u002Fonline\u002Fphone sessions; and (4) offering a comprehensive report on cognitive function, mobility, brain MRI, and monetary compensation for their time upon completion of the study.\n\nInvestigator will facilitate participant care by recording incidental findings from the MRI and providing clinical assessment data that may be shared with healthcare providers upon request. All personnel on the research team will be trained to detect\u002Fassess distress or any possibility of harm and respond appropriately.",[19],"Behavioral: Usual Care",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","The aerobic training sessions will involve standardized sets of stationary training, including on-spot jogging, burpees, aerobic steppers, agility ladders, and non-contact boxing. Each participant will rotate through the stations within the 40-minute training period, with one-minute of rest breaks in-between each station. A 20-point rate-of-perceived exertion will be used to monitor participant status during training with a target rate-of-perceived exertion of 16-17.\n\nThe resistance training sessions will involve utilizing free weights and resistance bands to stimulate muscle strength. The set of movements include triceps extension, dumbbell bicep curls, seated overhead dumbbell press, bent-over dumbbell row, wall squats, standing calf raises, wall push-ups.",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"Usual Care",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Chun Liang HSU, PhD","CONTACT","852-27666755","chun-liang.hsu@polyu.edu.hk",[36],{"facility":37,"status":38,"city":39,"state":39,"zip":40,"country":39,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"The Hong Kong Polytechnic University, Department of Rehabilitation Sciences","RECRUITING","Hong Kong","0000000","HK",{"type":43,"coordinates":44},"Point",[45,46],114.17469,22.27832,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":50,"phoneExt":25,"email":34},"27666755",{"type":52,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100632439","enhancing-physical-reserve-to-promote-resilience-in-physically-frail-older-adults-100632439",false,"NCT07513701","Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults","Enhancing Physical Reserve to Promote Cognitive and Physical Resilience in Physically Frail Older Adults: A 3-Month Randomized Controlled Trial","MRI exercise","Inclusion Criteria:\n\n1. are community-dwelling (i.e., not residing in a nursing home or extended care unit) ;\n2. scored \\\u003C 9\u002F12 on the SPPB;\n3. scored \\>18\u002F30 on the MoCA;\n4. are able to walk independently; use of walking aid is acceptable;\n5. are able to safely engage in exercise as indicated by the Physical Activity Readiness Questionnaire Plus33 and confirmed by their physician;\n6. have internet at home; and\n7. are able to provide written informed consent.\n\nExclusion Criteria:\n\n1. diagnosed with dementia or stroke;\n2. self-report engaging in strength and balance training exercises \\> two-times-per-week in the 3 months prior to screening;\n3. unable to understand, speak, and read Cantonese\u002FChinese\u002FEnglish proficiently; and\n4. contraindications for MRI such as MRI-incompatible implants.","ALL","60 Years","90 Years",{"count":65,"type":66},224,"ESTIMATED","INTERVENTIONAL",[69],"NA","The goal of this clinical trial is to assess the efficacy of combined aerobic and resistance training in enhancing physical reserve in older adults with physical frailty. Investigator contend that enhanced physical reserve will enable preservation of cognitive and physical function. The main questions aims to answer are: (1) Compared with usual care (i.e., CON), will 3-month aerobic and resistance training (ATRT) improve physical reserve in older adults with physical frailty? (2) Compared with CON, will ATRT lead to changes in the neural network organization? (3) Will improved physical reserve lead to better maintenance of cognitive and physical functioning in spite of presence of white matter hyperintensities (WMH)?",[72],"Frailty at Older Adults",[74,75,76,77,78],"physical frailty","aerobic exercise","resistance training","magnetic resonance imaging","physical reserve","2026-03-30",{"date":81,"type":82},"2026-04-07","ACTUAL",{"date":84,"type":82},"2026-01-19",{"date":86,"type":66},"2029-03-31",{"name":5,"class":6},1]