[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640519":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":42,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":10,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":10,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":65,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Ondokuz Mayıs University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HoLEP",null,"Males older than 18 years with lower urinary tract symptoms (LUTS) secondary to benign prostatic obstruction (BPO) who are planned to undergo holmium laser enucleation of the prostate (HoLEP) at participating centers.",[13],"Procedure: Holmium laser enucleation of prostate (HoLEP)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Holmium laser enucleation of prostate (HoLEP)","HoLEP is a widespread and minimally invasive surgical method to treat LUTS caused by BPO. En-bloc or tri-lobar technique will be performed according to the surgeon's preference during the procedure.",[9],[21],{"name":22,"affiliation":5,"role":23},"Murat Gulsen, Assistant Professor","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","+905062357421","mglotr@gmail.com",[30],{"facility":31,"status":10,"city":32,"state":10,"zip":10,"country":33,"countryCode":10,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Ondokuz Mayis University, Faculty of Medicine, Department of Urology","Samsun","Turkey (Türkiye)",{"type":35,"coordinates":36},"Point",[37,38],36.3361,41.27976,{"lat":38,"lon":37},[41],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},{"type":23,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Murat Gulsen","Assistant Professor","100640519","enucleation-ratio-as-a-novel-predictor-of-symptomatic-improvement-after-holep-100640519",false,"NCT07591688","Enucleation Ratio as a Novel Predictor of Symptomatic Improvement After HoLEP","Predictive Value of Enucleation Ratio for Symptomatic Improvement After HoLEP: A Multicenter Prospective Cohort Study","Inclusion Criteria:\n\n* Men aged 18 years pr older who are planned to undergo HoLEP.\n* Participants who are willing to give informed consent.\n* Participants who have moderate to severe LUTS (referring to IPSS score 8 points or more).\n* No history of previous prostate or urethral surgery.\n\nExclusion Criteria:\n\n* Unwillingness to provide informed consent.\n* Unwillingness to provide contact information or unreachability during follow-up periods.\n* Incidental diagnosis of a urogenital malignancy requiring primary treatment after enrollment (e.g., bladder tumor, renal cell carcinoma, testicular tumor).","MALE","18 Years",{"count":55,"type":56},400,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine whether the rate of prostate tissue removed during surgery relative to the preoperative total prostate volume (referred to as the \"enucleation ratio\") predicts symptomatic improvement 3 months after HoLEP. The main question it aims to answer is:\n\n\\- What is the minimum enucleation ratio required to achieve clinically important symptomatic improvement? (Symptomatic improvement is referred to as a threshold of having an International Prostate Symptom Score (IPSS) lower than 8 points, which is determined by the American Urological Association (AUA) and European Association of Urology(EAU)).",[60],"Benign Prostate Obstruction (BPO)",[9,62,63,64],"BPO","LUTS","Enucleation Ratio","NOT_YET_RECRUITING","2026-05-15",{"date":68,"type":69},"2026-05-19","ACTUAL",{"date":71,"type":56},"2026-07-01",{"date":73,"type":56},"2027-03-30",{"name":5,"class":6},1]