[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621345":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":38,"responsibleParty":72,"collaborators":10,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":10,"maxAge":10,"enrollmentInfo":83,"targetDuration":10,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Research Center Borstel","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Case group",null,"60 CF patients with a confirmed current or previously diagnosed NTM infection (according to ATS\u002FIDSA criteria)",[13],"Other: Multi-modal NTM diagnostic including PCR, WGS, culture",{"label":15,"type":10,"description":16,"interventionNames":17},"Control group","60 CF patients without a known or previously diagnosed NTM infection (according to ATS\u002FIDSA criteria)",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Multi-modal NTM diagnostic including PCR, WGS, culture","Environmental samples from participants' households (e.g., water, dust, and soil) will be collected and tested for the presence of NTM. Analyses will be performed using PCR, culture-based methods, whole-genome sequencing (WGS), and subsequent bioinformatic analyses. In addition, available clinical NTM isolates from previous or future routine diagnostics will be included. If genomic sequencing has not yet been performed for these isolates, retrospective molecular genetic analysis (e.g., by WGS) will be conducted within the study to enable comparison with environmental isolates.",[9,15],[24],{"name":25,"affiliation":26,"role":27},"Alexander Mischnik, Prof. Dr. med.","National and WHO-Supranational Reference Center for Mycobacteria, Research Center Borstel, Leibniz Lung Center","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Margo Diricks, PhD","CONTACT","+49 4537 \u002F 188-7540","mdiricks@fz-borstel.de",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":37},"Niklas Koehler, Dr. med.","+49 4537 188 8080","studienzentrum@fz-borstel.de",[39,57],{"facility":26,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Borstel","Schleswig-Holstein","23845","Germany","DE",{"type":47,"coordinates":48},"Point",[49,50],10.20407,53.81586,{"lat":50,"lon":49},[53,55,56],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":33},"Margo Dirics, PhD",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":37},{"name":25,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":58,"status":59,"city":60,"state":10,"zip":10,"country":44,"countryCode":45,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Klinik für Pneumologie, Universitätsklinikum Essen","NOT_YET_RECRUITING","Essen",{"type":47,"coordinates":62},[63,64],7.01228,51.45657,{"lat":64,"lon":63},[67,71],{"name":68,"role":31,"phone":69,"phoneExt":10,"email":70},"Sivagurunathan Sutharsan, PD Dr. med.","0201 433-4001","Sivagurunathan.Sutharsan@rlk.uk-essen.de",{"name":68,"role":27,"phone":10,"phoneExt":10,"email":10},{"type":27,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Alexander Mischnik","Prof. Dr. med. Alexander Mischnik","100621345","environmental-reservoirs-of-non-tuberculous-mycobacteria-in-cystic-fibrosis-households-a-case-control-study-of-exposure-risk-at-home-100621345",false,"NCT07369414","Environmental Reservoirs of Non-tuberculous Mycobacteria in Cystic Fibrosis Households: A Case-control Study of Exposure Risk at Home","NTMecoCF","Inclusion Criteria:\n\n* Confirmed diagnosis of cystic fibrosis (CF)\n* No age restriction (including minors with consent from legal guardians)\n* Written informed consent to participate in the study (or consent provided by a legal guardian for minors)\n* In the case of an NTM infection: diagnosis according to ATS\u002FIDSA criteria and availability of a clinical NTM isolate\n\nExclusion Criteria:\n\n* Lack of capacity to provide informed consent, refusal to participate, or withdrawal of informed consent","ALL",{"count":84,"type":85},120,"ESTIMATED","OBSERVATIONAL","This multicenter, non-interventional case-control study investigates whether household environmental reservoirs, particularly water systems, are associated with non-tuberculous mycobacterial (NTM) infections in people with cystic fibrosis. Environmental samples from the homes of CF patients with and without NTM infection will be analyzed and genetically compared with available clinical isolates, alongside assessment of environmental risk factors, to improve understanding of exposure pathways and inform future prevention strategies.",[89,90,91,92],"Cystic Fibrosis (CF)","Mucoviscidosis","Non-Tuberculous Mycobacteria","Mycobacterium Abscessus Infection",[94,95,96,97,98],"Environmental reservoirs","Household water systems","Microbial exposure","Whole-genome sequencing","Environmental risk factors","2026-01-16",{"date":101,"type":102},"2026-01-27","ACTUAL",{"date":104,"type":85},"2026-01",{"date":106,"type":85},"2030-12",{"name":5,"class":6},2]