[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590463":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":26,"responsibleParty":44,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":50,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Faculty Hospital Kralovske Vinohrady","OTHER_GOV",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Unvaccinated",null,"Without adjuvant vaccination for HPV",{"label":13,"type":10,"description":14,"interventionNames":10},"Vaccinated","Adjuvantly vaccinated against HPV with Gardasil-9",[16],{"name":17,"affiliation":18,"role":19},"Lukas Rob, Prof., MUDr., Csc.","Vascular surgery, University hospital Královské Vinohrady, Prague","PRINCIPAL_INVESTIGATOR",[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Lukas Rob, Prof. MUDr., Csc.","CONTACT","+420 296472368","lukas.rob@fnkv.cz",[27],{"facility":28,"status":29,"city":30,"state":10,"zip":31,"country":32,"countryCode":10,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"University Hospital Kralovske Vinohrady","RECRUITING","Prague","10034","Czechia",{"type":34,"coordinates":35},"Point",[36,37],14.42076,50.08804,{"lat":37,"lon":36},[40,41],{"name":17,"role":23,"phone":24,"phoneExt":10,"email":25},{"name":42,"role":43,"phone":10,"phoneExt":10,"email":10},"Nikola Janovska, MUDr.","SUB_INVESTIGATOR",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Nikola Janovska","Medical doctor, Department of Gynecology and Obstetrics","100590463","epidemiological-factors-and-optimization-of-conservative-approaches-to-precancerous-lesions-of-female-reproductive-organs-100590463",false,"NCT06967740","Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs","Inclusion Criteria:\n\n* Informed Consent\n* cervical biopsy - HG lesion\n* Age: 18-46 years\n* colposcopicaly visible transformation zone\n* HPV: Unvaccinated\n* cytology all except AIS, adenocarcinoma, squamous cell carcinoma, AGC NEO\n\nExclusion Criteria:\n\n* cytology AIS, AGC NEO, adenocarcinoma, squamous cell carcinoma\n* immunosuppression\n* active autoimmune disease\n* history of cervical cryodestruction\n* HPV vaccinated prior to start of the study","FEMALE","18 Years","46 Years",{"count":58,"type":59},200,"ESTIMATED","OBSERVATIONAL","The primary aim of this study is to develop a recommended clinical practice guideline for managing women with HPV HR (high-risk human papillomavirus) positivity and cervical lesions. Additionally, in collaboration with the Bioptic Laboratory, the study will analyze the integration of HPV HR testing into screening programs for women aged 35, 45, and 55, with a focus on optimizing management strategies for HPV HR-positive women.\n\nResearch Objectives:\n\n* Evaluate spontaneous regression\u002Fprogression over two years based on HPV HR genotyping (three groups - according to Alinity: high, intermediate, and low risk).\n* Assess spontaneous regression\u002Fprogression over two years based on HPV HR genotyping and viral load in HPV-vaccinated vs. non-vaccinated patients.\n* Evaluate spontaneous regression\u002Fprogression over two years based on methylation results.\n* Assess spontaneous regression\u002Fprogression over two years based on CinTec plus results.",[63,64,65,66],"Cervical Cancer","Cervical Intraepithelial Neoplasia (CIN)","Risk Factors","Conservative Management",[64,68,69],"Conservative management","Precancerous cervical lesions","2025-07-29",{"date":72,"type":73},"2025-07-31","ACTUAL",{"date":75,"type":73},"2024-11-01",{"date":77,"type":59},"2029-12",{"name":46,"class":6},1]