[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100546303":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":34,"responsibleParty":52,"collaborators":19,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":19,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":19,"enrollmentInfo":63,"targetDuration":19,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Southeast University, China","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"P-V curve group","EXPERIMENTAL","Enrolled patients will receive a PV curve with a low-flow insufflation of 5 L\u002Fmin starting from 0 cmH2O to a maximal airway pressure corresponding to the plateau pressure.",[13],"Other: pressure-volume curve with a low-flow insufflation of 5 L\u002Fmin",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"pressure-volume curve with a low-flow insufflation of 5 L\u002Fmin","The patient undergoes a pressure-volume curve with a low-flow insufflation of 5 L\u002Fmin while in a state of analgesia, sedation, and absence of spontaneous breathing.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"ling liu","Zhongda Hospital","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"ling liu, phD","CONTACT","15901599659","liulingdoctor@126.com",{"name":32,"role":28,"phone":19,"phoneExt":19,"email":33},"xueyan yuan, phD","18826401594@163.com",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University","RECRUITING","Nanjing","Jiangsu","210000","China","CN",{"type":44,"coordinates":45},"Point",[46,47],118.77778,32.06167,{"lat":47,"lon":46},[50],{"name":27,"role":28,"phone":51,"phoneExt":19,"email":30},"86-25-83272201",{"type":24,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Ling Liu","Director of Intensive Care Unit, Principal Investigator, Clinical Professor","100546303","epidemiology-and-treatment-strategy-of-open-respiratory-phenotype-in-critically-ill-patients-100546303",false,"NCT06393179","Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients","Inclusion Criteria:\n\n* Adult patients undergoing controlled mechanical ventilation\n* The duration of endotracheal intubation \\\u003C 48 hrs\n\nExclusion Criteria:\n\n* Severe hemodynamic instability\n* Severe chronic lung disease requiring long-term home oxygen therapy\n* Patients without analgesic sedation\n* Decline to participate in the study\n* Refusal to sign informed consent","ALL","18 Years",{"count":64,"type":65},60,"ESTIMATED","INTERVENTIONAL",[68],"NA","Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all. Airway pressure is supposed to completely interrupt the communication between proximal airway opening and the distal alveolar and\u002For small airway structures. In this condition, some alveoli may still be inflated but do not communicate with proximal airways and auto-PEEP will give a biased estimated of mean alveolar pressure. To be note, distinguishing the airway closure and alveolar collapse can be challenging at times. The quasi-static PV curve is a useful bedside tool to set mechanical ventilation, which may help us to identify the airway closure and alveolar collapse. Meanwhile, the quasi-static PV curve can only reflects a global behaviour of the lung, while EIT may be a useful tool to assess the regional information on airway closure and alveolar collapse.",[71,72],"Mechanical Ventilation Pressure High","Critical Illness",[74,75,76],"mechanical ventilation","airway closure","alveolar collapse","2024-08-13",{"date":79,"type":80},"2024-08-16","ACTUAL",{"date":82,"type":80},"2024-05-30",{"date":84,"type":65},"2024-08-30",{"name":5,"class":6},1]