[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549708":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":19,"responsibleParty":33,"collaborators":19,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":19,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":19,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":64,"whyStopped":19,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":19},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Percutaneous spinal cord stimulation","EXPERIMENTAL","All participants will undergo baseline muscle strength and force assessments. Participants will also answer questionnaires on pain and quality of life. An optional nerve health assessment with needle electromyography and neuroimaging may be performed.\n\nParticipants will undergo clinically indicated percutaneous (temporal) cervical epidural leads placement.\n\nWeeks 0-4 post-leads placement: during weekly visits upper extremity muscle strength and force will be assessed, pain and quality of life questionnaires will be completed (1 research visit per week)\n\nAt approximately 28 days temporary leads will be removed.\n\nAt the last visit, muscle strength and force in upper extremity muscle groups will be assessed, participants will complete pain and quality of life questionnaires. Participants may choose to undergo an optional nerve health assessment with needle electromyography and neuroimaging.",[13],"Device: Percutaneous spinal cord stimulation",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","The parameters of percutaneous cervical spinal cord stimulation leads will be adjusted for optimal upper extremity motor function.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Yi Lu, MD PhD","STUDY_CHAIR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Benjamin R. Johnston, MD PhD","CONTACT","(617) 525-7378","bjohnston2@mgb.org",{"name":31,"role":27,"phone":28,"phoneExt":19,"email":32},"Joshua I. Chalif, MD PhD","jchalif@bwh.harvard.edu",{"type":34,"investigatorFullName":22,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Director of Neurosurgical Trauma, Associate Professor of Neurosurgery","100549708","epidural-stimulation-for-upper-extremity-function-100549708",false,"NCT06437548","Epidural Stimulation for Upper Extremity Function","Spinal Cord Stimulation for Reanimation After Nervous System Injury","Inclusion Criteria:\n\n* Age ≥18 years and ≤65\n* Provides informed consent\n* History of upper extremity nerve transfer \\> 6 months prior to enrollment\n* Completion of standard post-nerve transfer occupational therapy\n* Baseline upper extremity strength of \\\u003C 5\u002F5 grade with the MRC\n* Scheduled to undergo a cervical spinal cord stimulation procedure for chronic pain refractory to first line therapy\n* Willing and able to adhere to the study protocol\n\nExclusion Criteria:\n\n* Central nervous system (CNS) malignancy\n* A contraindication to the SCS procedure\n* Diagnosis that precludes the patient from full participation in the protocol\n* A functional implanted device (pacemaker, vagus nerve device, baclofen pump)\n* Botulinum toxin injection in upper extremity muscles \\\u003C 6 months prior to enrollment\n* For female participants, current\u002Fplanned pregnancy (females of childbearing age will be asked to take a pregnancy test on the day of the intervention)\n* Other factors that prevent participation in the opinion of the surgeon-principal investigator","ALL","18 Years","65 Years",{"count":47,"type":48},20,"ESTIMATED","INTERVENTIONAL",[51],"NA","Restoring upper extremity function in patients with cervical spinal cord injury is extremely important for patients' independence and quality of life.\n\nAt present, there are limited options for hand or arm reanimation in this patient population. Nerve transfer is one such option that can partially restore the natural movement of hand or arm function in select patients.\n\nThe investigators are interested in understanding whether recovery of hand or arm motor function after nerve transfer can be augmented by cervical epidural spinal cord stimulation.",[54,55],"Spinal Cord Injury Cervical","Tetraplegia",[57,58,59,60,61,62,63],"spinal","cord","stimulation","percutaneous","peripheral","nerve","transfer","NOT_YET_RECRUITING","2024-05-30",{"date":67,"type":68},"2024-05-31","ACTUAL",{"date":70,"type":48},"2024-09",{"date":72,"type":48},"2027-09",{"name":5,"class":6}]