[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621125":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":34,"collaborators":10,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":10,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":50,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Bundang CHA Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Colorectal Adenoma Group",null,"Participants undergoing colonoscopic polypectomy for colorectal adenoma. Adenomatous tissue and adjacent normal mucosa will be collected for methylation and sequencing analysis.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"OneJoong KIM, M.D.","CONTACT","82+010+2111+0415","biblian@chamc.co.kr",[19],{"facility":5,"status":10,"city":20,"state":21,"zip":22,"country":23,"countryCode":10,"cosmosGeoPoint":24,"geoPoint":29,"contacts":30},"Seongnam-si","Gyeonggi-do","13496","South Korea",{"type":25,"coordinates":26},"Point",[27,28],127.13778,37.43861,{"lat":28,"lon":27},[31],{"name":32,"role":15,"phone":33,"phoneExt":10,"email":17},"KIM OneJoong","01021115353",{"type":35,"investigatorFullName":32,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Clinical Assistant Professor","100621125","epigenetic-factors-of-colorectal-adenoma-in-korean-100621125",false,"NCT07366554","Epigenetic Factors of Colorectal Adenoma in Korean","Exploration of Epigenetic Factors of Colorectal Adenoma in Korean","* Inclusion Criteria:\n\n  * Adults aged 19-85 years\n  * Undergoing colonoscopic polypectomy for colorectal adenoma\n  * Able to understand the study purpose and provide written informed consent\n  * Adequate tissue available for both adenoma and adjacent normal mucosa sampling\n* Exclusion Criteria:\n\n  * History of colorectal cancer, inflammatory bowel disease, or hereditary colorectal cancer syndrome (e.g., FAP, Lynch syndrome)\n  * Previous colorectal surgery that may alter anatomy or pathology\n  * Inadequate sample quality or failure of DNA extraction\n  * Refusal or withdrawal of informed consent\n  * Severe comorbidities that make participation unsuitable at investigator's discretion","ALL","19 Years","85 Years",{"count":48,"type":49},32,"ESTIMATED","1 Day","OBSERVATIONAL","This study aims to explore epigenetic factors associated with colorectal adenoma (CRA) in the Korean population. CRA is a key precancerous lesion in the adenoma-carcinoma sequence, and identifying methylated genetic markers may improve early detection and risk stratification for colorectal cancer (CRC).\n\nA total of 32 patients undergoing colonoscopic polypectomy will be enrolled. Adenomatous and adjacent normal tissues will be collected for deoxyribonucleic acid (DNA) extraction and bisulfite conversion. Quantitative methylation-specific polymerase chain reaction (qMSP) and Sanger sequencing will be used to assess the methylation status of candidate genes (SFRP2, TFPI2, SEPT9, and SDC2). Stool samples will also be analyzed by whole-genome sequencing (WGS) to evaluate microbiome and genetic profiles.\n\nThe study seeks to determine whether methylation levels of these genes are significantly elevated in adenoma tissue compared with normal mucosa, thereby identifying potential biomarkers for colorectal neoplasia surveillance and personalized colonoscopy follow-up intervals.",[54,55],"Colorectal Adenoma","Colorectal Cancer Precancerous Lesion",[54,57,58,59,60,61,62,63,64,65,66,67],"DNA Methylation","Epigenetics","Biomarker discovery","SFRP2","TFPI2","SEPT9","SDC2","qMSP","Korean population","Colorectal cancer prevention","Adenoma-carcinoma sequence","NOT_YET_RECRUITING","2026-01-25",{"date":71,"type":72},"2026-01-27","ACTUAL",{"date":74,"type":49},"2026-02-10",{"date":76,"type":49},"2027-05-09",{"name":5,"class":6},1]