[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641919":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":48,"centralContacts":53,"locations":63,"responsibleParty":84,"collaborators":29,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":29,"eligibilityCriteria":92,"healthyVolunteers":88,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":29,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":65,"whyStopped":29,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Taksim Egitim ve Arastirma Hastanesi","OTHER_GOV",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"ESPB + Standard-Flow Anaesthesia","ACTIVE_COMPARATOR","Participants will receive a preoperative bilateral ultrasound-guided ESPB with 20 mL of 0.25% bupivacaine on each side at the T7-T8 level, in addition to standard-flow sevoflurane anaesthesia during elective laparoscopic cholecystectomy. Fresh gas flow will be maintained at 3 L\u002Fmin during the maintenance phase of anaesthesia.",[13,14,15,16],"Procedure: Erector Spinae Plane Block","Other: Standard Fresh Gas Flow (3 L\u002Fmin)","Drug: Bupivacaine","Drug: Sevoflurane",{"label":18,"type":19,"description":20,"interventionNames":21},"ESPB + Low-Flow Anaesthesia","EXPERIMENTAL","Participants will receive a preoperative bilateral ultrasound-guided ESPB with 20 mL of 0.25% bupivacaine on each side at the T7-T8 level, in addition to low-flow sevoflurane anaesthesia during elective laparoscopic cholecystectomy. Following induction, fresh gas flow will be reduced to 0.5 L\u002Fmin during the maintenance phase of anaesthesia.",[13,22,15,16],"Other: Low Fresh Gas Flow (0.5 L\u002Fmin)",[24,30,35,39,44],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","Erector Spinae Plane Block","Bilateral ultrasound-guided erector spinae plane block (ESPB) will be performed preoperatively at the T7-T8 level",[18,9],null,{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":29},"OTHER","Low Fresh Gas Flow (0.5 L\u002Fmin)","Low-flow anaesthesia will be maintained with sevoflurane using a fresh gas flow rate of 0.5 L\u002Fmin after the initial high-flow phase following induction of general anaesthesia.",[18],{"type":31,"name":36,"description":37,"armGroupLabels":38,"otherNames":29},"Standard Fresh Gas Flow (3 L\u002Fmin)","Standard-flow anaesthesia will be maintained with sevoflurane using a fresh gas flow rate of 3 L\u002Fmin throughout the maintenance phase of general anaesthesia.",[9],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":29},"DRUG","Bupivacaine","Bupivacaine 0.25% will be administered bilaterally during ultrasound-guided erector spinae plane block at the T7-T8 level, with 20 mL injected on each side approximately 30 minutes before surgery.",[18,9],{"type":40,"name":45,"description":46,"armGroupLabels":47,"otherNames":29},"Sevoflurane","Sevoflurane will be used as the inhalational anaesthetic agent for maintenance of general anaesthesia during elective laparoscopic cholecystectomy. The fresh gas flow rate during maintenance will be determined according to study group allocation.",[18,9],[49],{"name":50,"affiliation":51,"role":52},"Leyla SIVACIGIL, MD","Taksim Training and Research Hospital","PRINCIPAL_INVESTIGATOR",[54,59],{"name":55,"role":56,"phone":57,"phoneExt":29,"email":58},"Leyla Sivacigil, MD","CONTACT","90 5065983478","veralleyla@hotmail.com",{"name":60,"role":56,"phone":61,"phoneExt":29,"email":62},"Celal Kaya, MD","90 5435176760","celalmadime@gmail.com",[64],{"facility":51,"status":65,"city":66,"state":29,"zip":67,"country":68,"countryCode":29,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"RECRUITING","Istanbul","34000","Turkey (Türkiye)",{"type":70,"coordinates":71},"Point",[72,73],28.94966,41.01384,{"lat":73,"lon":72},[76,78,80,81],{"name":55,"role":56,"phone":77,"phoneExt":29,"email":58},"905065983478",{"name":60,"role":56,"phone":79,"phoneExt":29,"email":62},"905435176760",{"name":55,"role":52,"phone":29,"phoneExt":29,"email":29},{"name":82,"role":83,"phone":29,"phoneExt":29,"email":29},"celal kaya, MD","SUB_INVESTIGATOR",{"type":85,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100641919","erector-spinae-plane-block-and-low-flow-anaesthesia-in-laparoscopic-cholecystectomy-100641919",false,"NCT07653490","Erector Spinae Plane Block and Low-Flow Anaesthesia in Laparoscopic Cholecystectomy","Evaluation of the Effects of Preoperative Erector Spinae Plane Block Combined With Low-Flow Anaesthesia on Postoperative Quality of Recovery and Opioid Consumption: A Prospective, Randomized, Controlled Study","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* ASA physical status I-II\n* Body mass index (BMI) \\\u003C35 kg\u002Fm²\n* Scheduled for elective laparoscopic cholecystectomy\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Coagulopathy or bleeding disorders\n* Allergy to local anaesthetic agents\n* Infection at the block application site\n* Neurological or psychiatric disorders\n* Communication difficulties\n* Chronic opioid or analgesic use\n* Reoperation cases\n* Acute cholecystitis\n* Conversion to open surgery\n* Inadequate dermatomal block after ESPB\n* Severe intraoperative hemodynamic instability\n* Intraoperative blood loss ≥250 mL\n* Development of allergic reactions or major complications during follow-up","ALL","18 Years","65 Years",{"count":97,"type":98},72,"ESTIMATED","INTERVENTIONAL",[101],"NA","This prospective randomized controlled study aims to evaluate the effects of preoperative ultrasound-guided erector spinae plane (ESP) block combined with low-flow anaesthesia on postoperative quality of recovery and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The study will compare postoperative recovery quality, pain scores, analgesic requirements, and perioperative outcomes between patients receiving ESP block with low-flow anaesthesia and those receiving standard anaesthetic management.",[104,105],"Postoperative Pain","Laparoscopic Cholecystectomy",[26,107,108,109,105],"Low-Flow Anaesthesia","Opioid Consumption","Enhanced Recovery","2026-06-18",{"date":112,"type":113},"2026-06-23","ACTUAL",{"date":110,"type":113},{"date":116,"type":98},"2027-06-18",{"name":5,"class":6},1]