[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622995":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":37,"centralContacts":38,"locations":44,"responsibleParty":64,"collaborators":69,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":37,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":37,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":47,"whyStopped":37,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intramyometrial Ergometrine Injection","ACTIVE_COMPARATOR","Participants receive intramyometrial injection of methylergometrine maleate diluted in saline and administered circumferentially around the myoma before uterine incision during abdominal myomectomy.",[13],"Drug: Methylergometrine (Intramyometrial Injection)",{"label":15,"type":16,"description":17,"interventionNames":18},"Intramyometrial Carbetocin Injection","EXPERIMENTAL","Participants receive intramyometrial injection of carbetocin diluted in saline and administered circumferentially around the myoma before uterine incision during abdominal myomectomy.",[19],"Drug: Carbetocin (Intramyometrial Injection)",[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Methylergometrine (Intramyometrial Injection)","Methylergometrine maleate is administered as an intramyometrial injection diluted in normal saline and injected circumferentially around the myoma before uterine incision during abdominal myomectomy to induce sustained uterine contraction and reduce surgical blood loss.",[9],[27,28,29],"Methylergometrine maleate","Ergometrine","Methergine",{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Carbetocin (Intramyometrial Injection)","Carbetocin is administered as an intramyometrial injection diluted in normal saline and injected circumferentially around the myoma before uterine incision during abdominal myomectomy to promote sustained uterine contraction and reduce intraoperative and postoperative blood loss.",[15],[35,36],"Carbetocin","Long-acting oxytocin analogue",null,[39],{"name":40,"role":41,"phone":42,"phoneExt":37,"email":43},"Ahmed E Abd eltawab, MD","CONTACT","+201091355562","aea11@fayoum.edu.eg",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Fayoum University","RECRUITING","Al Fayyum","Faiyum Governorate","38521","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],30.8418,29.30995,{"lat":57,"lon":56},[60],{"name":61,"role":41,"phone":62,"phoneExt":37,"email":63},"Haitham M Badran, MD","01000151515","haitham.badran@fayoum.edu.eg",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":68,"oldNameTitle":37,"oldOrganization":37},"PRINCIPAL_INVESTIGATOR","ahmed nagy shaker ramadan","Assistant lecturer of obstetrics and gynecology","Kafrelsheikh University",[70],{"name":68,"class":6},"100622995","ergometrine-versus-carbetocin-to-decrease-blood-loss-in-myomectomy-100622995",false,"NCT07390864","Ergometrine Versus Carbetocin to Decrease Blood Loss in Myomectomy","Intramyometrial Ergometrine Injection Versus Intramyometrial Carbetocin Injection to Decrease Blood Loss During and After Abdominal Myomectomy: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Female participants aged 25 to 48 years\n* Body mass index (BMI) \\\u003C 35 kg\u002Fm²\n* Symptomatic uterine fibroids requiring surgical management (e.g., abnormal uterine bleeding, pelvic pain, or pressure symptoms)\n* Intramyometrial uterine myomas classified as FIGO types 3 to 6, diagnosed by transvaginal ultrasonography or magnetic resonance imaging\n* Maximum diameter of the largest myoma ≤ 20 cm\n* Eligible for and scheduled to undergo abdominal myomectomy\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* FIGO type 0, 1, 2, 7, or 8 myomas (intracavitary, submucosal, pedunculated subserosal, cervical, or adnexal)\n* History of pelvic inflammatory disease, peritonitis, or significant abdominal or pelvic infection\n* History of prior uterine surgery\n* Use of hormonal treatment within 3 months prior to enrollment\n* Contraindication to methylergometrine or carbetocin, including:\n* Known drug allergy\n* Hypertension\n* Cardiac or pulmonary disease\n* Chronic endocrine or metabolic disease (e.g., diabetes mellitus)\n* Renal or hepatic impairment\n* High risk of bleeding, including:\n* Known bleeding disorders\n* Current use of antiplatelet or anticoagulant therapy\n* Preoperative anemia (hemoglobin \\\u003C 10 g\u002FdL)\n* BMI ≥ 35 kg\u002Fm²\n* Intraoperative conversion from myomectomy to hysterectomy","FEMALE","25 Years","48 Years",{"count":82,"type":83},40,"ESTIMATED","INTERVENTIONAL",[86],"NA","The goal of this randomized clinical trial is to determine whether intramyometrial ergometrine injection or intramyometrial carbetocin injection is more effective in reducing blood loss during and after abdominal myomectomy in women undergoing surgery for symptomatic uterine fibroids.\n\nThe main questions it aims to answer are:\n\nDoes intramyometrial ergometrine reduce intraoperative and postoperative blood loss during abdominal myomectomy?\n\nDoes intramyometrial carbetocin reduce intraoperative and postoperative blood loss during abdominal myomectomy?\n\nIs there a difference between the two drugs in the need for blood transfusion and postoperative hemoglobin drop?\n\nResearchers will compare intramyometrial ergometrine injection with intramyometrial carbetocin injection to see which intervention is more effective in controlling surgical bleeding and improving surgical outcomes.\n\nParticipants will:\n\nUndergo abdominal myomectomy for uterine fibroids\n\nReceive either intramyometrial ergometrine or intramyometrial carbetocin during surgery\n\nBe monitored for intraoperative blood loss, postoperative blood loss, hemoglobin changes, and need for blood transfusion",[89],"Myoma;Uterus",[28,35,91,92],"Blood Loss","Abdominal Myomectomy","2026-02-01",{"date":95,"type":96},"2026-02-05","ACTUAL",{"date":98,"type":96},"2026-01-18",{"date":100,"type":83},"2026-08-30",{"name":5,"class":6},1]