[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100457770":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":48,"responsibleParty":300,"collaborators":32,"id":302,"slug":303,"hasResults":304,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":32,"eligibilityCriteria":308,"healthyVolunteers":304,"sex":309,"minAge":310,"maxAge":32,"enrollmentInfo":311,"targetDuration":32,"studyType":314,"phases":315,"briefSummary":317,"conditions":318,"keywords":321,"overallStatus":51,"whyStopped":32,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":338},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exposure and Response Prevention (ERP)","EXPERIMENTAL","ERP will be based upon the Treatments That Work series, which contains both a provider manual and client workbook. Sessions will last 90 minutes and occur weekly for 16 sessions. All ERP treatment will be delivered via VTH. Participants will receive instructions on accessing the VTH platform and take part in a brief practice run connecting to the VTH appointment with guidance from an RA. ERP treatment content includes psychoeducation about OCD, assessment of OCD symptoms, the rationale for treatment, construction of a hierarchy or a list of feared or avoided situations, and in-session in-vivo and imaginal exposures. Weekly homework assignments will include self-monitoring, reading chapters about the treatment, and practicing exposures daily. All therapy sessions will be audio-recorded. Although sessions are expected to occur weekly, accounting for delays due to scheduling, holidays, and missed appointments, the investigators will allow up to 6 months to complete the treatment.",[13],"Behavioral: Exposure and Response Prevention",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Condition","OTHER","Participants randomized to the control condition will receive 16 weekly sessions of stress management training via video telehealth. This control condition was chosen because it is expected to provide the therapeutic alliance and common factors associated with therapy generally and some specific effects in anxiety reduction.",[19],"Other: Stress Management Training",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Exposure and Response Prevention","ERP is a specialized cognitive behavioral intervention conducted over the course of 8-16 therapy sessions. ERP is based upon exposure principles and the idea that people can habituate to the distress caused by OCD triggers and learn to cope with anxiety about feared consequences without engaging in compulsive behaviors to 'neutralize' the obsession. ERP begins with psychoeducation about OCD and exposure, followed by construction of a hierarchy, or list, of situations that are feared, avoided, or trigger OCD rituals such as washing or checking. Then, the therapist and client begin in-session exposures to hierarchy items utilizing response or ritual prevention techniques to avoid reinforcing the ritual. Exposures can be in vivo, such as touching a contaminated item, or imaginal, such as visualizing a feared consequence happening.",[9],[27],"ERP",{"type":16,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Stress Management Training","The stress management training intervention will be based on that delivered by Simpson in an ERP trial. It will be delivered by PhD and Master's level therapists from each site's clinics. The stress management training intervention will begin with an introductory session providing psychoeducation about OCD, followed by 15 sessions covering stress management skills such as deep breathing progressive muscle relaxation, positive imagery, assertiveness training, and problem solving. Each session will contain an extended practice of the selected skill and will end with homework assignments to practice the stress management skills and monitor symptoms.",[15],null,[34],{"name":35,"affiliation":36,"role":37},"Terri L. Fletcher, PhD","Michael E. DeBakey VA Medical Center, Houston, TX","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":32,"email":43},"Terri L Fletcher, PhD","CONTACT","(713) 440-4400","Terri.Fletcher@va.gov",{"name":45,"role":41,"phone":46,"phoneExt":32,"email":47},"Matthew G Escamilla, BS","(713) 440-4461","matthew.escamilla@va.gov",[49,71,84,96,109,121,137,149,161,173,189,201,218,231,238,251,263,275,288],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ","RECRUITING","East Orange","New Jersey","07018","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-74.20487,40.76732,{"lat":61,"lon":60},[64,68],{"name":65,"role":41,"phone":66,"phoneExt":32,"email":67},"Jennifer Schneider, PhD","347-498-4068","Jennifer.Schneider2@va.gov",{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},"8324681668","Matthew.Escamilla@va.gov",{"facility":72,"status":51,"city":73,"state":74,"zip":75,"country":55,"countryCode":56,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"VA Western New York Healthcare System, Buffalo, NY","Buffalo","New York","14215-1129",{"type":58,"coordinates":77},[78,79],-78.87837,42.88645,{"lat":79,"lon":78},[82,83],{"name":65,"role":41,"phone":66,"phoneExt":32,"email":67},{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":85,"status":51,"city":74,"state":74,"zip":86,"country":55,"countryCode":56,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"VA NY Harbor Healthcare System, New York, NY","10010-5011",{"type":58,"coordinates":88},[89,90],-74.00597,40.71427,{"lat":90,"lon":89},[93,94],{"name":65,"role":41,"phone":66,"phoneExt":32,"email":67},{"name":95,"role":41,"phone":69,"phoneExt":32,"email":70},"Matthew, BS",{"facility":97,"status":51,"city":98,"state":74,"zip":99,"country":55,"countryCode":56,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Northport VA Medical Center, Northport, NY","Northport","11768-2200",{"type":58,"coordinates":101},[102,103],-73.34317,40.90093,{"lat":103,"lon":102},[106,107],{"name":65,"role":41,"phone":66,"phoneExt":32,"email":67},{"name":108,"role":41,"phone":69,"phoneExt":32,"email":70},"Matthew Escamilla, BS",{"facility":110,"status":51,"city":111,"state":74,"zip":112,"country":55,"countryCode":56,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"James J. Peters VA Medical Center, Bronx, NY","The Bronx","10468-3904",{"type":58,"coordinates":114},[115,116],-73.86641,40.84985,{"lat":116,"lon":115},[119,120],{"name":65,"role":41,"phone":66,"phoneExt":32,"email":67},{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":122,"status":51,"city":123,"state":124,"zip":125,"country":55,"countryCode":56,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Asheville VA Medical Center, Asheville, NC","Asheville","North Carolina","28805-2576",{"type":58,"coordinates":127},[128,129],-82.55402,35.60095,{"lat":129,"lon":128},[132,136],{"name":133,"role":41,"phone":134,"phoneExt":32,"email":135},"Holly Hunley, PhD","708-473-1203","Holly.Hunley@va.gov",{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":138,"status":51,"city":139,"state":124,"zip":140,"country":55,"countryCode":56,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"Durham VA Medical Center, Durham, NC","Durham","27705-3875",{"type":58,"coordinates":142},[143,144],-78.89862,35.99403,{"lat":144,"lon":143},[147,148],{"name":133,"role":41,"phone":134,"phoneExt":32,"email":135},{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":150,"status":51,"city":151,"state":124,"zip":152,"country":55,"countryCode":56,"cosmosGeoPoint":153,"geoPoint":157,"contacts":158},"Fayetteville VA Medical Center, Fayetteville, NC","Fayetteville","28301-3856",{"type":58,"coordinates":154},[155,156],-78.87836,35.05266,{"lat":156,"lon":155},[159,160],{"name":133,"role":41,"phone":134,"phoneExt":32,"email":135},{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":162,"status":51,"city":163,"state":124,"zip":164,"country":55,"countryCode":56,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC","Salisbury","28144",{"type":58,"coordinates":166},[167,168],-80.47423,35.67097,{"lat":168,"lon":167},[171,172],{"name":133,"role":41,"phone":134,"phoneExt":32,"email":135},{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":174,"status":51,"city":175,"state":176,"zip":177,"country":55,"countryCode":56,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"VA Roseburg Healthcare System, Roseburg, OR","Roseburg","Oregon","97471",{"type":58,"coordinates":179},[180,181],-123.34174,43.2165,{"lat":181,"lon":180},[184,188],{"name":185,"role":41,"phone":186,"phoneExt":32,"email":187},"Milena S Roussev, PhD","206-303-8274","Milena.Roussev@va.gov",{"name":45,"role":41,"phone":32,"phoneExt":32,"email":47},{"facility":190,"status":51,"city":191,"state":176,"zip":192,"country":55,"countryCode":56,"cosmosGeoPoint":193,"geoPoint":197,"contacts":198},"VA Southern Oregon Rehabilitation Center and Clinics, White City, OR","White City","97503",{"type":58,"coordinates":194},[195,196],-122.832,42.43735,{"lat":196,"lon":195},[199,200],{"name":185,"role":41,"phone":186,"phoneExt":32,"email":187},{"name":45,"role":41,"phone":32,"phoneExt":32,"email":70},{"facility":202,"status":51,"city":203,"state":204,"zip":205,"country":55,"countryCode":56,"cosmosGeoPoint":206,"geoPoint":210,"contacts":211},"Ralph H. Johnson VA Medical Center, Charleston, SC","Charleston","South Carolina","29401-5703",{"type":58,"coordinates":207},[208,209],-79.93275,32.77632,{"lat":209,"lon":208},[212,216],{"name":213,"role":41,"phone":214,"phoneExt":32,"email":215},"Ursula S Myers, PhD","843-252-3880","ursula.myers@va.gov",{"name":45,"role":41,"phone":217,"phoneExt":32,"email":47},"7137948601",{"facility":36,"status":51,"city":219,"state":220,"zip":221,"country":55,"countryCode":56,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"Houston","Texas","77030-4211",{"type":58,"coordinates":223},[224,225],-95.36327,29.76328,{"lat":225,"lon":224},[228,229],{"name":45,"role":41,"phone":46,"phoneExt":32,"email":47},{"name":35,"role":230,"phone":32,"phoneExt":32,"email":32},"SUB_INVESTIGATOR",{"facility":36,"status":51,"city":219,"state":220,"zip":221,"country":55,"countryCode":56,"cosmosGeoPoint":232,"geoPoint":234,"contacts":235},{"type":58,"coordinates":233},[224,225],{"lat":225,"lon":224},[236,237],{"name":40,"role":41,"phone":42,"phoneExt":32,"email":43},{"name":35,"role":37,"phone":32,"phoneExt":32,"email":32},{"facility":239,"status":51,"city":240,"state":241,"zip":242,"country":55,"countryCode":56,"cosmosGeoPoint":243,"geoPoint":247,"contacts":248},"Hampton VA Medical Center, Hampton, VA","Hampton","Virginia","23667",{"type":58,"coordinates":244},[245,246],-76.34522,37.02987,{"lat":246,"lon":245},[249,250],{"name":133,"role":41,"phone":134,"phoneExt":32,"email":135},{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":252,"status":51,"city":253,"state":241,"zip":254,"country":55,"countryCode":56,"cosmosGeoPoint":255,"geoPoint":259,"contacts":260},"Hunter Holmes McGuire VA Medical Center, Richmond, VA","Richmond","23249-0001",{"type":58,"coordinates":256},[257,258],-77.46026,37.55376,{"lat":258,"lon":257},[261,262],{"name":133,"role":41,"phone":134,"phoneExt":32,"email":135},{"name":108,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":264,"status":51,"city":265,"state":241,"zip":266,"country":55,"countryCode":56,"cosmosGeoPoint":267,"geoPoint":271,"contacts":272},"Salem VA Medical Center, Salem, VA","Salem","24153-6404",{"type":58,"coordinates":268},[269,270],-80.05476,37.29347,{"lat":270,"lon":269},[273,274],{"name":133,"role":41,"phone":134,"phoneExt":32,"email":135},{"name":45,"role":41,"phone":69,"phoneExt":32,"email":70},{"facility":276,"status":51,"city":277,"state":278,"zip":279,"country":55,"countryCode":56,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"Spokane VA Medical Center, Spokane, WA","Spokane","Washington","99205-6185",{"type":58,"coordinates":281},[282,283],-117.42908,47.65966,{"lat":283,"lon":282},[286,287],{"name":185,"role":41,"phone":186,"phoneExt":32,"email":187},{"name":45,"role":41,"phone":32,"phoneExt":32,"email":47},{"facility":289,"status":51,"city":290,"state":278,"zip":291,"country":55,"countryCode":56,"cosmosGeoPoint":292,"geoPoint":296,"contacts":297},"Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA","Walla Walla","99362-3975",{"type":58,"coordinates":293},[294,295],-118.34302,46.06458,{"lat":295,"lon":294},[298,299],{"name":185,"role":41,"phone":186,"phoneExt":32,"email":187},{"name":45,"role":41,"phone":32,"phoneExt":32,"email":70},{"type":301,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100457770","erp-to-improve-functioning-in-veterans-with-ocd-100457770",false,"NCT05240924","ERP to Improve Functioning in Veterans With OCD","Exposure and Response Prevention to Improve Functioning in Veterans With Obsessive Compulsive Disorder","Inclusion Criteria:\n\n* Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska: the VISN 2 Clinical Resource Hub which provides telehealth services to New Jersey, New York, and northern Pennsylvania, and the VISN 6 Clinical Resource Hub which provides telehealth services to North Carolina and Virginia.\n* Willingness to participate in Exposure and Response Prevention(ERP)\n\nExclusion Criteria:\n\n* Significant cognitive impairment or conditions that threaten safety (current psychosis, mania, imminent suicidality including plan or intent, and treatment-interfering moderate to severe substance use).\n* Potential participants taking psychotropic medications must be on a stable dose of these medications for at least 6 weeks prior to study enrollment.","ALL","18 Years",{"count":312,"type":313},160,"ESTIMATED","INTERVENTIONAL",[316],"NA","Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.",[319,320],"Obsessive Compulsive Disorder (OCD)","Comorbid Post-Traumatic Stress Disorder and OCD",[322,323,324,325,326,327,328],"Obsessive Compulsive Disorder","OCD","Post-Traumatic Stress Disorder","PTSD","Worry","Compulsion","Stress","2026-06-04",{"date":331,"type":332},"2026-06-08","ACTUAL",{"date":334,"type":332},"2022-10-03",{"date":336,"type":313},"2027-05-31",{"name":5,"class":6},19]