[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100077248":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":22,"centralContacts":27,"locations":33,"responsibleParty":85,"collaborators":88,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":7,"eligibilityCriteria":99,"healthyVolunteers":96,"sex":100,"minAge":101,"maxAge":7,"enrollmentInfo":102,"targetDuration":7,"studyType":105,"phases":7,"briefSummary":106,"conditions":107,"keywords":113,"overallStatus":35,"whyStopped":7,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",null,[9,13,16,19],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"PROCEDURE","Survey of client health, personal habits, family history","A questionnaire is administered at the time of consent.",{"type":10,"name":14,"description":15,"armGroupLabels":7,"otherNames":7},"Blood specimen for non-DNA and DNA parts","Blood specimen is collected prior to surgery or at the time of scheduled routine surgical procedure(s), and at the time of routine follow-up visits",{"type":10,"name":17,"description":18,"armGroupLabels":7,"otherNames":7},"Biopsy of esophageal\u002Fstomach tissue, lymph nodes, tumor","Tissue from the biopsies is collected intraoperatively.",{"type":10,"name":20,"description":21,"armGroupLabels":7,"otherNames":7},"Biopsies, oral (saliva) and\u002For secretions, washings or mucosal scrapings\u002Fbrushing from routine clinical surveillance endoscopies","Tissue from the biopsies, oral (saliva) and\u002For secretions, washings or mucosal scrapings\u002Fbrushings are collected intraoperatively.",[23],{"name":24,"affiliation":25,"role":26},"James D. Luketich, MD","Department of Cardiothoracic Surgery","PRINCIPAL_INVESTIGATOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":7,"email":32},"Julie A Ward, BSN","CONTACT","412-647-8583","wardj@upmc.edu",[34],{"facility":25,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Pittsburgh","Pennsylvania","15232","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-79.99589,40.44062,{"lat":45,"lon":44},[48,50,52,55,57,59,61,63,65,67,69,71,73,75,77,79,81,83],{"name":49,"role":30,"phone":31,"phoneExt":7,"email":32},"Julie Ward, BSN",{"name":51,"role":26,"phone":7,"phoneExt":7,"email":7},"James Luketich, MD",{"name":53,"role":54,"phone":7,"phoneExt":7,"email":7},"Neil Christie, MD","SUB_INVESTIGATOR",{"name":56,"role":54,"phone":7,"phoneExt":7,"email":7},"Matthew Schuchert, MD",{"name":58,"role":54,"phone":7,"phoneExt":7,"email":7},"Arjun Pennathur, MD",{"name":60,"role":54,"phone":7,"phoneExt":7,"email":7},"Ryan Levy, MD",{"name":62,"role":54,"phone":7,"phoneExt":7,"email":7},"Omar Awais, DO",{"name":64,"role":54,"phone":7,"phoneExt":7,"email":7},"Vera Donnenberg, PhD",{"name":66,"role":54,"phone":7,"phoneExt":7,"email":7},"Olivera Finn, PhD",{"name":68,"role":54,"phone":7,"phoneExt":7,"email":7},"Tadeusz Witek, MD",{"name":70,"role":54,"phone":7,"phoneExt":7,"email":7},"Joel Greenberger, MD",{"name":72,"role":54,"phone":7,"phoneExt":7,"email":7},"Evan Alicuben, MD",{"name":74,"role":54,"phone":7,"phoneExt":7,"email":7},"Navid Ajabshir, MD",{"name":76,"role":54,"phone":7,"phoneExt":7,"email":7},"Renee Levesque, MD",{"name":78,"role":54,"phone":7,"phoneExt":7,"email":7},"Christian Otero, MD",{"name":80,"role":54,"phone":7,"phoneExt":7,"email":7},"Thomas Melvin, MD",{"name":82,"role":54,"phone":7,"phoneExt":7,"email":7},"James Ackerman, MD",{"name":84,"role":54,"phone":7,"phoneExt":7,"email":7},"Juan Munoz-Largacha, MD",{"type":26,"investigatorFullName":86,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"James Luketich","MD",[89,92],{"name":90,"class":91},"National Institutes of Health (NIH)","NIH",{"name":93,"class":91},"National Cancer Institute (NCI)","100077248","esophageal-cancer-risk-registry-100077248",false,"NCT00260585","Esophageal Cancer Risk Registry","Inclusion Criteria:\n\n* Known or suspected esophageal or gastroesophageal junction malignancy\n* Known Barrett's metaplasia\n* Clinical management of symptomatic gastroesophageal reflux disease (GERD)\n* Achalasia\n* Hiatal hernia\n\nExclusion Criteria:\n\n* Elevated pre-operative bloodwork will not have the additional biopsies taken.\n* Platelet count less than 150,000, partial thromboplastin time (PTT) of 50 or above, and\u002For International Normalized Ratio (INR) of 1.8 or above will not have the additional biopsies taken.","ALL","18 Years",{"count":103,"type":104},7000,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer. This research aims to collect medical history, blood, and tissue samples from patients who present with an esophageal disorder. Identifying genetic and behavioral risk factors involved in the development of esophageal cancer might allow for early detection and prevention. Survival and an opportunity for a cure with esophageal cancer will depend greatly on the stage of diagnosis. Tumors can develop changes in their genetic (hereditary) make-up, and these changes can sometimes be seen in normal tissues before the development of cancer. These genetic (hereditary) changes can serve as tumor markers and can be detected using methods that study changes in genetic material like DNA and RNA. The analysis of proteins can provide additional information. By identifying changes in these molecules that are different or altered in cancer, the investigators can use methods and tests for the detection of these changes.",[108,109,110,111,112],"Esophageal Cancer","Gastroesophageal Reflux Disease (GERD)","Esophageal Diseases","Hiatal Hernia","Esophageal Achalasia",[114,115,116,117,118,119,120,121,122],"gastroesophageal reflux disease","GERD","hiatal hernia","achalasia","Barrett's metaplasia","Anti-Reflux Surgery","Known\u002Fsuspected esophageal\u002Fgastroesophageal junction tumor","Esophageal disorders such as Barrett's metaplasia","Symptomatic gastroesophageal reflux disease","2026-04-09",{"date":125,"type":126},"2026-04-14","ACTUAL",{"date":128,"type":126},"1999-06",{"date":130,"type":104},"2050-12",{"name":5,"class":6},1]