[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605868":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":44,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Shanghai 6th People's Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Heathy Volunteers",null,"120 Healthy Volunteers for the establishment of reference intervals of salivary cortisol",{"label":13,"type":10,"description":14,"interventionNames":10},"Cushing's sydrome","50 cases diagnosed with Cushing's sydrome",{"label":16,"type":10,"description":17,"interventionNames":10},"Adrenal insufficiency","50 cases diagnosed with adrenal insufficiency",[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Jian Zhou, Doctor","CONTACT","+86-021-64369181","zhoujian@sjtu.edu.cn",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Shanghai Sixth People's Hospital","RECRUITING","Shanghai","Shanghai Municipality","200233","China","CN",{"type":34,"coordinates":35},"Point",[36,37],121.45806,31.22222,{"lat":37,"lon":36},[40],{"name":41,"role":21,"phone":42,"phoneExt":10,"email":43},"Yufei Zhou, B.S.","16621727469","zyf2020@sjtu.edu.cn",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jian Zhou","Principal Investigator, Professor, Chief Physician, Deputy Director","100605868","establishment-and-clinical-application-of-reference-intervals-of-salivary-cortisol-100605868",false,"NCT07168122","Establishment and Clinical Application of Reference Intervals of Salivary Cortisol","Study for Reference Intervals and Optimal Cut-offs for Salivary Cortisol","Healthy Volunteers:\n\nInclusion Criteria:\n\n1. Age ≥ 18 and ≤ 60 years old;\n2. Body mass index (BMI) ≥ 18.5 and ≤ 24.9 kg\\*m\\^-2;\n3. No previous history of chronic diseases such as hyperglycemia, hypertension, dyslipidemia, coronary heart disease and stroke;\n4. Normal glucose regulation, defined as: fasting blood-glucose \\\u003C 5.6 mmol\u002FL, 2-hour blood-glucose after glucose load \\\u003C 7.8 mmol\u002FL, and glycated hemoglobin (HbA1c) \\\u003C 5.7%.\n\nExclusion Criteria:\n\n1. Liver or kidney dysfunction, alanine aminotransferase (ALT) or aspartate aminotransferase (AST) or direct bilirubin higher than 1.5 times the upper limit of normal, or serum creatinine \\>115 μmol\u002FL;\n2. Pregnancy or lactation women, or people with cancer or mental illness;\n3. Factors affecting cortisol levels, including hypothalamus-pituitary-adrenal axis disease, autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis, etc.), diagnosed mental disease, Alzheimer's disease, alcoholism (alcohol \\> 60 g\u002Fd for male, \\>40 g\u002Fd for women) and corticosteroid therapy in the past 3 months (females with contraceptives or estrogen);\n4. Factors affecting saliva collection, such as serious oral problems (oral ulcers, gingival bleeding);\n5. Night shift workers, who are awake from 11:00 PM to 7:00 AM;\n6. Acute infection (body temperature ≥ 37.3 ℃ or C-reactive protein \\> 50 mg\u002FL).\n\nCases:\n\nInclusion Criteria:\n\n1. Aged 18 to 80 years old;\n2. Patients with suspected Cushing's syndrome or adrenal insufficiency.\n\nExclusion Criteria:\n\n1. Corticosteroid therapy within the last 6 weeks;\n2. Acute infection;\n3. Severe oral conditions;\n4. Severe liver and kidney dysfunction;\n5. Alcoholism, depression, or other psychiatric disorders.",true,"ALL","18 Years","80 Years",{"count":60,"type":61},220,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to establish the normal reference intervals of salivary cortisol and optimal cut-offs for Cushing's sydrome and adrenal insufficiency.",[65,66,67],"Healthy Adult","Cushing Syndrome","Adrenal Insufficiency","2025-09-04",{"date":70,"type":71},"2025-09-11","ACTUAL",{"date":73,"type":61},"2025-09-01",{"date":75,"type":61},"2027-12-31",{"name":5,"class":6},1]