[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100416458":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":27,"responsibleParty":47,"collaborators":49,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":76,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patient with Monoclonal gammopathies of inflammatory significance",null,"This group of patient will present a monoclonal gammopathy associated with inflammatory symptoms without known origin.",{"label":13,"type":10,"description":14,"interventionNames":10},"Control group","The Control group will be healthy subject and patients with monoclonal gammopathies without inflammatory symptoms.",[16],{"name":17,"affiliation":5,"role":18},"Sophie GEORGIN-LAVIALLE, PU-PH","PRINCIPAL_INVESTIGATOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","01 56 01 60 77","sophie.georgin-lavialle@aphp.fr",{"name":25,"role":21,"phone":22,"phoneExt":10,"email":26},"Gilles GRATEAU","gilles.grateau@aphp.fr",[28],{"facility":29,"status":10,"city":30,"state":10,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Service de Médecine Interne","Paris","75020","France","FR",{"type":35,"coordinates":36},"Point",[37,38],2.3488,48.85341,{"lat":38,"lon":37},[41,44],{"name":42,"role":21,"phone":43,"phoneExt":10,"email":23},"Sophie GEORGIN-LAVIALLE, MD PhD","+33 1 56 01 60 77",{"name":45,"role":21,"phone":46,"phoneExt":10,"email":26},"Gilles GRATEAU, PU-PH","+33 1 49 28 25 20",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[50],{"name":51,"class":52},"INSERM UMR 1163","UNKNOWN","100416458","establishment-of-genomic-transcriptomic-and-functional-characteristics-of-tumor-cells-in-hyperinflammatory-hemopathies-100416458",false,"NCT04702932","Establishment of Genomic, Transcriptomic and Functional Characteristics of Tumor Cells in Hyperinflammatory Hemopathies","GEN-HEMO-INF","Inclusion Criteria:\n\n* Patient over 18 years of age with the capacity to give express free and informed consent.\n* Patient followed in one of the services participating in the study and meeting the 2 following conditions\n\n  1. have myelodysplastic syndrome, or multiple myeloma, or monoclonal gammopathy of undetermined significance, or Schnitzler's syndrome.\n  2. have a fever of undetermined etiology associated with one of the following symptoms: rash, arthralgia or arthritis, serositis, abdominal pain.\n\nExclusion Criteria:\n\n* Patient incapable of giving express free and informed consent.\n* Subject under guardianship, curatorship or safeguarding of justice.\n* Subject does not speak French.\n* Subject incapable of answering questions or expressing himself\u002Fherself.\n* Presence of a differential diagnosis that may explain the patient's symptoms.","ALL","18 Years",{"count":63,"type":64},30,"ESTIMATED","OBSERVATIONAL","Patients with monoclonal gammopathies either benign or malignant may develop inflammatory symptoms such as Schnitzler syndrome. We proposed to name those cases as monoclonal gammopathy of inflammatory significance, or MGIS.\n\nThe aim of the study is to search for inflammatory pathway that may be activated in case MGIS and to search if the genetic of tumoral cell could explain those activations.",[68,69,70],"Monoclonal Gammopathy of Undetermined Significance","Multiple Myeloma","Waldenstrom Macroglobulinemia",[72,73,74,75],"Autoinflammatory syndromes","Monoclonal gammopathies of unknown significance","Multiple myeloma","Waldenstrom macroglobulinemia","NOT_YET_RECRUITING","2021-01-08",{"date":79,"type":80},"2021-01-11","ACTUAL",{"date":82,"type":64},"2021-09-01",{"date":84,"type":64},"2036-09-01",{"name":5,"class":6},1]