[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635242":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":26,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":88,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Reading","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ETAS® (1500mg)","EXPERIMENTAL","Subjects will consume 1500mg ETAS®\u002Fday (capsule).",[13],"Dietary Supplement: ETAS®",{"label":15,"type":16,"description":17,"interventionNames":18},"Matched placebo","PLACEBO_COMPARATOR","Subjects will consume a matched placebo capsule.",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","ETAS®","1500mg ETAS®",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Matched placebo capsule",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Piril Hepsomali, PhD","CONTACT","+44 118 378 5818","p.hepsomali@reading.ac.uk",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"University of Reading, School of Psychology and Clinical Languages","RECRUITING","Reading","Berkshire","RG6 6ES","United Kingdom","UK",{"type":47,"coordinates":48},"Point",[49,50],-0.97113,51.45625,{"lat":50,"lon":49},[53],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Piril Hepsomali","Principle Investigator",[59],{"name":60,"class":61},"Amino Up Chemicals Co., Ltd.","INDUSTRY","100635242","etascan-project-etas-project-2-100635242",false,"NCT07550140","ETASCAN Project: ETAS Project 2","The Impact of Chronic Consumption of ETAS® for 12 Weeks on Cognitive, Affective, and Neural Outcomes: A Randomised Parallel Group Placebo-controlled Study","ETASCAN","Inclusion Criteria:\n\n* Aging between 60-80 years old\n* Having normal vision and hearing\n* Having a body mass index between 18.5 and 30\n* Having mild to moderate subjective cognitive complaints\n\nExclusion Criteria:\n\n* Smoking\n* Having food allergies\n* Following restrictive and\u002For unbalanced diets (Appendix 6: Are you vegetarian or vegan? Yes \u002F No; Are you currently on a weight-reducing or other special diet? Yes\u002FNo If 'Yes', please give details.)\n* Being diagnosed with any psychiatric or neurologic conditions (e.g. schizophrenia, depression, dementia) including eating disorders\n* Being diagnosed with any cardiometabolic diseases (including type II diabetes and cardiovascular disease), or hypertension or thrombosis related disorders or suffer from thyroid disease\n* Currently taking anticoagulants, antiplatelet medication, antidepressants, proton-pump inhibitors\n* Currently consuming prebiotic or probiotic supplements\n* Continuous antibiotic use for \\> 3 days within 1 month prior to enrolment\n* Continuous use of weight-loss drug for \\> 1 month before screening\n* Having a significant gastrointestinal (GI) condition affecting absorption including (but not limited to) inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end stage renal disease; active cancer, or treatment for any cancer, in last 3 years\n* History of claustrophobia\n* Fitted with a pacemaker or artificial heart valve\n* Have active implants, such as cochlear, ocular, or penile implant\n* Experience of metal fragments e.g. shrapnel in your eyes or any other part of your body\n* Drug infusion pump installed\n* Have any surgically implanted metal in any part of your body, other than dental fillings and crowns (e.g. joint replacement or bone re-construction)\n* Have had any surgery that might have involved metal implants\n* Current or historical experience of epilepsy\n* Have stimulators for nerves, brain or bone installed\n* Have an intrauterine contraceptive device installed (IUD)\n* Wear transdermal patches containing metal\n* Wear a filling, crown, dental post (entirely within the tooth) associated with root canal treatment, retainer, bridge or braces\n* For scanning, would need to remove coloured contact lenses, nail polish and makeup.\n* Hearing aid wearer\n* Body piercings that you cannot or will not remove for the scanning session\n* Have tattoos or permanent makeup",true,"ALL","60 Years","80 Years",{"count":75,"type":76},60,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study aims to investigate the chronic effects of ETAS® on cognitive, affective and neural outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.",[82,83,84,85,86,87],"Cognition","Affect (Mental Function)","Sleep","MRI","fMRI","Magnetic Resonance Spectroscopy",[89,90,91,92,93,94,23,95,96,97,98],"grey matter","brain structure","brain function","neurochemistry","executive function","language","depression","anxiety","sleep","gut microbiome","2026-04-17",{"date":101,"type":102},"2026-04-24","ACTUAL",{"date":104,"type":76},"2026-05-05",{"date":106,"type":76},"2027-12-31",{"name":5,"class":6},1]