[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100301875":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":66,"collaborators":10,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":10,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":10,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"The Cleveland Clinic","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Alcoholic Steatosis",null,"This group will have 10 patients with alcoholic steatosis which is milder disease and muscle biopsies will be performed",[13],"Other: Biopsies",{"label":15,"type":10,"description":16,"interventionNames":17},"Cirrhosis","This group will consist of 10 patients with cirrhosis. We anticipate a 50% difference in these patients and the controls in the autophagy readouts and muscle biopsies will be performed",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Steatohepatitis","This group will have 10 patients with alcoholic steatohepatitis that have more severe necroinflammation in the liver but for a shorter duration of illness and muscle biopsies will be performed",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"controls","This group will consist of 10 patients who are healthy and have no liver disease diagnosis and muscle biopsies will be performed",[13],[27],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Biopsies","Biopsy will be done on the Vastus Lateralis muscle in all groups",[9,15,19,23],[32],{"name":33,"affiliation":5,"role":34},"Srinivasan Dasarathy, MD","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Revathi Penumatsa, MPH","CONTACT","2164450688","penumar@ccf.org",{"name":42,"role":38,"phone":43,"phoneExt":10,"email":44},"Annette Bellar, MSLA","2166365247","bellara@ccf.org",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Cleveland Clinic","RECRUITING","Cleveland","Ohio","44195","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-81.69541,41.4995,{"lat":58,"lon":57},[61,64],{"name":62,"role":38,"phone":63,"phoneExt":10,"email":40},"Revathi Penumatsa","216-445-0688",{"name":65,"role":38,"phone":43,"phoneExt":10,"email":44},"Annette Bellar",{"type":34,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Srinivasan Dasarathy","Staff Physician","100301875","ethanol-induces-skeletal-muscle-autophagy-100301875",false,"NCT03209791","Ethanol Induces Skeletal Muscle Autophagy","Mechanisms of Skeletal Muscle Proteolysis With Ethanol Consumption: an Integrated Molecular Metabolic Approach","Inclusion Criteria:\n\nAlcoholic liver disease:\n\n* clinical, biochemical, imaging criteria and liver biopsy where available\n* Age 18 - 65 years old\n\nControls:\n\n* Serum liver transaminases (i.e. ALT and AST) 40 IU\u002FL\n* Normal liver ultrasound\n* Age 18 - 65 years old\n\nExclusion Criteria:\n\nFor both groups - alcoholic liver disease and controls:\n\n* Poorly controlled diabetes mellitus (HbA1C\\>9.5 g\u002Fdl)\n* Untreated Hyper- \u002F hypo- thyroidism\n* Patients on dialysis, renal disease with serum creatinine 1.5 mg\u002FdL\n* Active intravenous drug use\n* History of bowel surgery or gastric bypass surgery\n* Medications known to alter muscle protein metabolism (i.e. corticosteroids, tamoxifen, high-dose estrogen, testosterone or anabolic steroids)\n* Metastatic disease, Advanced cardiac or pulmonary disease\n* Pregnancy\n* Coagulopathy- INR \\>1.4 and platelet count \\\u003C80,000\u002Fml.",true,"ALL","18 Years","65 Years",{"count":81,"type":82},40,"ESTIMATED","OBSERVATIONAL","In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.",[86],"Alcoholic Liver Disease","2026-01-08",{"date":89,"type":90},"2026-01-09","ACTUAL",{"date":92,"type":90},"2015-05-18",{"date":94,"type":82},"2027-12-31",{"name":5,"class":6},1]