[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645298":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":70,"collaborators":72,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":26,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":26,"enrollmentInfo":91,"targetDuration":26,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":55,"whyStopped":26,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"I.M. Sechenov First Moscow State Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Comprehensive Etiological Diagnosis Group","EXPERIMENTAL","Patients receive standard diagnostics plus molecular test results (PCR, PCR with sequencing) to guide etiotropic therapy",[13],"Diagnostic Test: Molecular tests (PCR, sequencing)",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Clinical Practice Group","ACTIVE_COMPARATOR","Patients receive standard care; molecular test results are blinded for the treating physician",[19],"Diagnostic Test: Standard Clinical Practice",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIAGNOSTIC_TEST","Molecular tests (PCR, sequencing)","PCR and PCR with consequent sequencing of the blood (or tissue) will be performed in addition to the cultural methods in the experimental study arm",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard Clinical Practice","Patients receive standard care with analysis of microorganisms in at least 2 or more separate blood culture sets and from cardiac tissue (if surgical treatment is performed); molecular test results are blinded for the treating physician",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Svetlana Rachina, Professor","CONTACT","+7 910 715-89-55","rachina_s_a@staff.sechenov.ru",[38,53,62],{"facility":39,"status":40,"city":41,"state":26,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health","NOT_YET_RECRUITING","Moscow","Russia","RU",{"type":45,"coordinates":46},"Point",[47,48],37.61781,55.75204,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":26,"phoneExt":26,"email":26},"Dmitry Popov, Prof",{"facility":54,"status":55,"city":41,"state":26,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":56,"geoPoint":58,"contacts":59},"City Clinical Hospital Named After S. S. Yudin","RECRUITING",{"type":45,"coordinates":57},[47,48],{"lat":48,"lon":47},[60],{"name":61,"role":34,"phone":35,"phoneExt":26,"email":36},"Svetlana Rachina",{"facility":63,"status":55,"city":41,"state":26,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"City Clinical Hospital №67 Named After L. A. Vorokhobova",{"type":45,"coordinates":65},[47,48],{"lat":48,"lon":47},[68],{"name":69,"role":34,"phone":26,"phoneExt":26,"email":26},"Svetlana Mirzakhamidova, Dr",{"type":71,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[73,76,78,80],{"name":74,"class":75},"Federal State Budgetary Institution of the Central Research Institute of Epidemiology of Rospotrebnadzor","UNKNOWN",{"name":77,"class":75},"City Clinical Hospital Named After S. S. Yudin, Moscow, Russian Federation",{"name":79,"class":75},"City Clinical Hospital №67 Named After L. A. Vorokhobova, Moscow, Russian Federation",{"name":81,"class":75},"A.N. Bakulev National Medical Research Center for Cardiovascular Surgery of the Russian Ministry of Health, Moscow, Russian Federation","100645298","etiologic-diagnosis-algorithm-in-infective-endocarditis-100645298",false,"NCT07682389","Etiologic Diagnosis Algorithm in Infective Endocarditis","Development and Validation of An Algorithm of Etiological Diagnosis of Infective Endocarditis in Adults: An Open-Label Multicenter Randomized Clinical Trial","Inclusion Criteria:\n\n* Informed consent,\n* Age ≥ 18,\n* IE (definite or possible per the 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis)\n\nExclusion Criteria:\n\n* Pregnancy\u002Fbreastfeeding\n* Unconfirmed or rejected IE diagnosis,\n* Very high risk of death within 14 days due to severe complications of the main or concomitant disease(s), according to the physician's opinion;\n* Prior use of antibiotic therapy (except documented treatment failure).","ALL","18 Years",{"count":92,"type":93},128,"ESTIMATED","INTERVENTIONAL",[96],"NA","The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis",[99,100],"Infective Endocarditis","Microbiology",[102,103,104,105,106],"Infective endocarditis","PCR","Antibiotic therapy","Etiological diagnosis","Sequencing","2026-06-28",{"date":109,"type":110},"2026-07-02","ACTUAL",{"date":112,"type":110},"2026-01-20",{"date":114,"type":93},"2027-02-20",{"name":5,"class":6},3]