[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593308":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":63,"collaborators":26,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":26,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Patan Academy of Health Sciences","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard of Care","ACTIVE_COMPARATOR","Standard of care evaluation of a febrile patient is done by the treating medical team which usually consists of the following set of clinical, basic laboratory, radiological and microbiological evaluations: History and Evaluation; Basic Lab Tests; Radiological Investigations; Routine Serologies; Microbiological Investigations",[13],"Diagnostic Test: Standard of Care (SOC)",{"label":15,"type":16,"description":17,"interventionNames":18},"Study Arm","EXPERIMENTAL","For patients without an obvious cause of fever and an inconclusive work up after standard of care evaluations, additional serological tests as a part of undifferentiated febrile illness work up will be performed including clinical evaluation; additional microbiological evaluation and laboratory testing other than that in the standard care",[19],"Diagnostic Test: Additional laboratory analysis",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIAGNOSTIC_TEST","Additional laboratory analysis","Additional lab tests will be done to establish the diagnosis of Murine typhus, Bartonellosis, Q-fever, Chikungunya, Zika, Japanese B encephalitis, West Nile virus",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard of Care (SOC)","Standard of care evaluation of a febrile patient is done by the treating medical team as Standard of care evaluation of a febrile patient is done by the treating medical team which includes clinical, basic laboratory, radiological and microbiological evaluations",[9],[32],{"name":33,"affiliation":5,"role":34},"Janak Koirala, MD MPH","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Janak Koirala, MD MPH FIDSA","CONTACT","+9779818762117","janakkoirala@pahs.edu.np",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Lalitpur","Bagmati","44709","Nepal","NP",{"type":50,"coordinates":51},"Point",[52,53],80.74671,28.58667,{"lat":53,"lon":52},[56,57,58,61],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":37,"role":34,"phone":26,"phoneExt":26,"email":26},{"name":59,"role":60,"phone":26,"phoneExt":26,"email":26},"Nora Ranjitkar, MD","SUB_INVESTIGATOR",{"name":62,"role":60,"phone":26,"phoneExt":26,"email":26},"Suman Thapa, MD",{"type":34,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Janak Koirala","Professor of Medicine and Infectious diseases","100593308","etiology-of-febrile-illness-in-nepal-define-study-100593308",false,"NCT07004751","Etiology of Febrile Illness in Nepal (DEFINe Study)","Determination of Etiology of Febrile Illness in Nepal (DEFINe Study)","DEFINe","Inclusion Criteria:\n\n* Age 16 years or older\n* Documented fever (T ≥100.4F or ≥38C) of 3 days to 21 days duration\n* No obvious diagnosis found on the basis of clinical, radiological, or initial routine laboratory tests\\*\n* Admitted to the medical unit of hospital\n* Signed ICF (informed consent form)\n\nExclusion Criteria:\n\n* Outpatients\n* Fever of less than 3 days or more than 21 days duration\n* Patients being discharged from Emergency Room\n* Children (younger than 16 years in age)\\*\\*\n* Immunocompromised patients\n* Neutropenia (ANC \\\u003C500 per cumm)\n* Known case of HIV infection\n* Admission to a hospital for 48-hours or longer within past 30 days","ALL","16 Years",{"count":77,"type":78},194,"ESTIMATED","INTERVENTIONAL",[81],"NA","In the absence of a microbiological lab testing, majority of the cases of febrile illnesses in Nepal are diagnosed on a clinical basis alone. These cases of \"undifferentiated febrile illness\" are treated empirically with multiple antibiotics without an etiological diagnosis. Unnecessary use of antibiotics can increase the risk of antibiotic resistance and adds unnecessary burden of cost to the patients and their families.\n\nThis study aims to determine the etiology of infections using additional microbiological techniques in patients admitted to the hospital with acute undifferentiated febrile illness of 3 days to 21 days duration, and assess its impact on use of antimicrobial drugs. In addition to the clinical features, the etiological diagnosis will be confirmed by using additional tests including culture techniques and ELISA based serological tests for 7 additional pathogens which are currently not tested in Nepal. Patients meeting definition of undifferentiated fever of 3 days to 21 days duration will be enrolled from a major tertiary care center using predefined inclusion and exclusion criteria.This study will help to identify additional infectious diseases prevalent in Nepal, decrease unnecessary empirical use of multiple antibiotics, and improve patient outcome. Additionally, identification of new causes of febrile illness will help in prevention and control of these infectious diseases at public health level.",[84,85],"Febrile Illness","Fever Without Source",[87],"Febrile Illnes","2025-07-29",{"date":90,"type":91},"2025-08-03","ACTUAL",{"date":93,"type":91},"2025-07-04",{"date":95,"type":78},"2026-10-01",{"name":5,"class":6},1]