[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538689":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":57,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":25,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Virginia Polytechnic Institute and State University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"eTMS","EXPERIMENTAL","The active side of a TMS coil will be used to administer eTMS application.",[13],"Device: Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"eTMS sham","SHAM_COMPARATOR","The sham side of a TMS coil will be used to administer a sham dosage of eTMS application.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)","EEG is utilized to determine a personalized frequency to then apply TMS to the frontal lobe.",[9,15],null,[27],{"name":28,"affiliation":5,"role":29},"Wynn Legon, PhD","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Jessica Florig, MPH","CONTACT","540-526-2261","jnw@vtc.vt.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Fralin Biomedical Research Institute","RECRUITING","Roanoke","Virginia","24016","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-79.94143,37.27097,{"lat":49,"lon":48},[52,53],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":28,"role":29,"phone":25,"phoneExt":25,"email":25},{"type":29,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Wynn Legon","Assistant Professor",[58],{"name":59,"class":60},"Wave Neuroscience","INDUSTRY","100538689","etms-for-veterans-and-first-responders-with-ptsd-100538689",false,"NCT06294106","eTMS for Veterans and First Responders With PTSD","Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder (PTSD)","Inclusion Criteria:\n\n* Veteran or first responder\n* diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above\n\nExclusion Criteria:\n\n* Claustrophobia\n* Contraindications to MRI\n* Pregnant\n* Uncontrolled medical, psychological, or neurological conditions\n* Unable to calculate EEG alpha frequency\n* History of ECT or rTMS\n* History of intracranial lesion or increased intracranial pressure\n* History of stroke\n* History of other neurologic conditions\n* Family history of epilepsy\n* Personal history of epilepsy\n* certain medications","ALL","18 Years","65 Years",{"count":72,"type":73},20,"ESTIMATED","INTERVENTIONAL",[76],"NA","A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.",[79],"Post Traumatic Stress Disorder","2026-06-30",{"date":82,"type":83},"2026-07-02","ACTUAL",{"date":85,"type":83},"2024-06-10",{"date":87,"type":73},"2028-09",{"name":5,"class":6},1]