[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100435560":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":41,"responsibleParty":63,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":25,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EUS-CPN with bupivacaine","ACTIVE_COMPARATOR","Endoscopic ultrasound guided celiac plexus neurolysis with absolute alcohol 20 mL preceded by injection of 10 ml of bupivacaine 0.5%.",[13],"Procedure: EUS-CPN with bupivacaine",{"label":15,"type":16,"description":17,"interventionNames":18},"EUS-CPN without bupivacaine","EXPERIMENTAL","Endoscopic ultrasound guided celiac plexus neurolysis with absolute alcohol 20 mL only.",[19],"Procedure: EUS-CPN without bupivacaine",[21,26],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Under conscious sedation, an echoendoscope is advanced into the stomach, just distal to the gastro-esophageal junction. The region of the celiac plexus is identified around the takeoff of the celiac artery from the aorta. Then, under real-time ultrasound guidance, a 19g needle is used to inject a neurolytic agent such as absolute alcohol around the base of the celiac artery.",[15],null,{"type":22,"name":9,"description":27,"armGroupLabels":28,"otherNames":25},"Under conscious sedation, an echoendoscope is advanced into the stomach, just distal to the gastro-esophageal junction. The region of the celiac plexus is identified around the takeoff of the celiac artery from the aorta. Then, under real-time ultrasound guidance, a 19g needle is used to firstly inject bupivacaine and secondly a neurolytic agent such as absolute alcohol around the base of the celiac artery.",[9],[30],{"name":31,"affiliation":32,"role":33},"ANAND V SAHAI, MD","Centre de Recherche du Centre Hospitalier de l'Université de Montréal","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"CHARLES MACKAY, RN","CONTACT","514-890-8000","36484","charles.mackay.chum@ssss.gouv.qc.ca",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Centre de recherche du Centre hospitalier de l'Université de Montréal","RECRUITING","Montreal","Quebec","H2X 0A9","Canada","CA",{"type":51,"coordinates":52},"Point",[53,54],-73.58781,45.50884,{"lat":54,"lon":53},[57,58,60],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},{"name":59,"role":33,"phone":25,"phoneExt":25,"email":25},"Anand V Sahai, MD",{"name":61,"role":62,"phone":25,"phoneExt":25,"email":25},"Sarto Paquin, MD","SUB_INVESTIGATOR",{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100435560","eus-cpn-with-and-without-bupivacaine-100435560",false,"NCT04951804","EUS-CPN With and Without Bupivacaine","A Randomized Controlled Trial of Endoscopic Ultrasound Guided Celiac Plexus Neurolysis (EUS-CPN) With and Without Bupivacaine","EUS-NB","Inclusion Criteria:\n\n1. Malignant-appearing pancreatic mass, or proven pancreatic cancer involving the pancreatic genu, body, or tail\n2. Any level of abdominal or back pain considered to be potentially related to the mass:\n\n   1. New onset pain (\\\u003C3 months)\n   2. Constant\n   3. Centrally located\n   4. With or without irradiation to the back\n   5. No obvious other source of pain based on history and physical examination by the attending endosonographer\n3. No possibility of surgical management\n4. Signed, informed consent\n5. Celiac axis accessible for bilateral neurolysis at EUS.\n\nExclusion Criteria:\n\n1\\. Allergy to bupivacaine","ALL","18 Years",{"count":76,"type":77},180,"ESTIMATED","INTERVENTIONAL",[80],"NA","Endoscopic ultrasound (EUS) allows EUS-guided trans gastric injection of absolute alcohol around the base of the celiac plexus (celiac plexus neurolysis (EUS-CPN)), to help alleviate pain associated with pancreatic cancer.\n\nIt is standard procedure to inject bupivacaine immediately before injecting absolute alcohol, to theoretically prevent pain that may occur during and after the procedure. However, there are no data showing whether bupivacaine injection has any real influence on intra-procedural, immediate post-procedural, or long-term pain control. The injection of bupivacaine before the alcohol may have no effect, a synergistic effect, or an antagonistic effect, by diluting the alcohol, and reducing its neurolytic capacity. Inadvertent intravascular injection of bupivacaine may also cause irreversible cardiac arrhythmias and death.\n\nThe investigators therefore propose a randomized clinical trial to determine whether the exclusion of bupivacaine during EUS-guided CPN improves outcomes, or not.",[83],"Pancreatic Cancer",[83,85,86,87,88,89],"Celiac plexus neurolysis","Bupivacaine","Endoscopic ultrasound","With Bupivacaine","Without Bupivacaine","2026-04-20",{"date":92,"type":93},"2026-04-23","ACTUAL",{"date":95,"type":93},"2021-10-07",{"date":97,"type":77},"2029-12",{"name":5,"class":6},1]