[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100408903":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":36,"responsibleParty":54,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":10,"eligibilityCriteria":65,"healthyVolunteers":62,"sex":66,"minAge":10,"maxAge":10,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"M.D. Anderson Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Ancillary-correlative (biospecimen collection, chart review)",null,"Patients undergo collection of blood samples and 6 brushings of the airway during SOC bronchoscopy. Patients' medical records are also reviewed for data collection.",[13,14],"Procedure: Biospecimen Collection","Other: Medical Chart Review",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"PROCEDURE","Biospecimen Collection","Undergo collection of blood, airway brushings.",[9],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Medical Chart Review","Patients' medical records are reviewed",[9],[26],"Chart Review",[28],{"name":29,"affiliation":5,"role":30},"Ajay Sheshadri","PRINCIPAL_INVESTIGATOR",[32],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":35},"CONTACT","713-792-6238","asheshadri@mdanderson.org",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"M D Anderson Cancer Center","RECRUITING","Houston","Texas","77030","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-95.36327,29.76328,{"lat":49,"lon":48},[52,53],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":10},{"name":29,"role":30,"phone":10,"phoneExt":10,"email":10},{"type":55,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[57],{"name":58,"class":59},"National Institute of Allergy and Infectious Diseases (NIAID)","NIH","100408903","evaluating-clonogenic-epithelial-cell-populations-in-patients-with-bronchiolitis-obliterans-syndrome-100408903",false,"NCT04604522","Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome","Inclusion Criteria:\n\n* Allo-HCT recipients undergoing a bronchoscopy at MDACC who consent to undergoing study airway brushings in addition to clinically indicated bronchoscopic procedures (e.g. bronchoalveolar lavage)\n\n  * 5 patients with advanced BOS - forced expiratory volume in one second (FEV1) =\\\u003C 75% predicted and meeting other National Institutes of Health (NIH) criteria (FEV1\u002Fforced vital capacity \\[FVC\\] ratio 0.7, presence of air trapping or graft versus host disease \\[GVHD\\] of another organ)\n  * 5 patient with early BOS - at least 10% decline in FEV1 from baseline values, with FEV1 \\>= 75% predicted, and 1 high-risk feature:\n\n    * Active systemic chronic GVHD with new early airflow obstruction OR\n    * Respiratory viral infection in last three months with resolution of viral symptoms but new airflow obstruction\n  * 3 patients with no pulmonary impairment (FEV1 within 5% of baseline values)\n* Lung allograft recipients undergoing a bronchoscopy at Houston Methodist who consent to undergoing study airway brushing sin addition to clinically indicated bronchoscopy procedures\n\n  * 5 patients with BOS Stage 2 or higher (\\>= 35% decline in FEV1 from baseline values)\n  * 5 patient with BOS Stage 0p or 1 (10-35% decline in FEV1 from baseline values)\n  * 3 patients undergoing screening bronchoscopy without decline in FEV1\n  * patients with undiagnosed lung cancer and chronic obstructive pulmonary disease diagnosed by pulmonary function testing (FEV1\u002FFVC less than the lower limit of normal with \\>20 pack-year history of smoking)\n\nExclusion Criteria:\n\n* Bronchoscopy performed on emergency basis for life-threatening issues as opposed to routine diagnostic testing\n* Patient unwilling to give consent for study airway brushings","ALL",{"count":68,"type":69},15,"ESTIMATED","OBSERVATIONAL","This study investigates a type of cell, called abnormal clonogenic epithelial cells, in patients with bronchiolitis obliterans syndrome who have had an donor stem cell transplant or a lung transplant. Learning more about clonogenic cells in these patients may help doctors to detect signs of bronchiolitis obliterans syndrome earlier in future patients.",[73],"Bronchiolitis Obliterans","2026-03-09",{"date":76,"type":77},"2026-03-11","ACTUAL",{"date":79,"type":77},"2020-08-27",{"date":81,"type":69},"2026-03-31",{"name":5,"class":6},1]