[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579629":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":43,"responsibleParty":62,"collaborators":32,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":32,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":32,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":45,"whyStopped":32,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Spaulding Rehabilitation Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cerebrovascular Control with Q-Collar","EXPERIMENTAL","Participants will undergo measurements of cerebral blood flow during changes in body position (sit-to-stand) and resistance breathing tasks while wearing a properly fitted Q-collar to evaluate how the Q-Collar affects cerebrovascular responses to rapid and sinusoidal shifts in blood pressure.",[13],"Device: Q30 Q-Collar",{"label":15,"type":16,"description":17,"interventionNames":18},"Cerebrovascular Control without Q-Collar","PLACEBO_COMPARATOR","Participants will undergo measurements of cerebral blood flow during changes in body position (sit-to-stand) and resistance breathing tasks without wearing a Q-collar.",[19],"Other: Not wearing Q-Collar",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Q30 Q-Collar","Participants will complete a series of tests (sit-to-stand, resistive breathing, and graded bike test) while wearing a Q-Collar.",[9],[27],"Q-Collar",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Not wearing Q-Collar","Participants will undergo the same study procedures without wearing the Q-Collar.",[15],null,[34],{"name":35,"affiliation":36,"role":37},"J. Andrew Taylor, MS, PhD","Harvard Medical School\u002FSpaulding Rehabilitation Hospital","PRINCIPAL_INVESTIGATOR",[39],{"name":35,"role":40,"phone":41,"phoneExt":32,"email":42},"CONTACT","617-758-5503","jandrew_taylor@hms.harvard.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Cambridge","Massachusetts","02138","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-71.10561,42.3751,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":60,"phoneExt":32,"email":61},"Glen Picard, MS","617-758-5511","GPICARD@PARTNERS.ORG",{"type":37,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"J. Andrew Taylor","PhD","100579629","evaluating-q-collar-effects-on-brain-blood-flow-control-during-exercise-100579629",false,"NCT06826781","Evaluating Q-Collar Effects on Brain Blood Flow Control During Exercise","Evaluating Q-Collar Effects on Cerebrovascular Control in Response to Exercise","Inclusion Criteria:\n\n* healthy individuals between the ages of 18 to 30 years old\n\nExclusion Criteria:\n\n* History of concussion or other brain injury resulting in loss or alteration in consciousness or other change in cognition within 24 months of study visit\n* High cardiac risk according to the American College of Sports Medicine (ACSM)11\n* Ongoing active treatment with a cardioactive drug\n* Inability to stand from a seated position unassisted\n* History of a neurologic disorder or neurosurgery intervention\n* Pregnancy\n* Any current, serious, chronic medical or psychiatric disease that in the Principal Investigator's or co-investigator's judgment may interfere with study participation or data integrity\n* Unable or unwilling to provide informed consent",true,"ALL","18 Years","30 Years",{"count":77,"type":78},20,"ESTIMATED","INTERVENTIONAL",[81],"NA","The goal of this clinical trial is to learn how the FDA-cleared Q-Collar device affects brain blood flow regulation during rest and exercise in healthy adults. The main questions this study aims to answer are:\n\n1. How does the Q-Collar affect brain blood flow when there are quick changes in blood pressure, like when standing up quickly, or when breathing against resistance?\n2. How does the Q-Collar affect brain blood flow during exercise?\n\nResearchers will compare sessions where participants wear the Q-Collar to sessions where they do not wear the device to see if the Q-Collar improves brain blood flow during both rest and exercise.\n\nParticipants will:\n\n* Complete two study visits, each 1 to 4 weeks apart.\n* Perform a series of tasks, including standing tests, breathing tests, and exercise on a stationary bike, while their heart rate, brain blood flow, and other body functions are monitored.\n* Wear the Q-Collar during one of the sessions and not wear it during the other session. The order of the sessions will be randomly assigned.",[84],"Healthy",[27,86,87],"Cerebrovascular Blood Flow Regulation","Exercise","2025-10-23",{"date":90,"type":91},"2025-10-27","ACTUAL",{"date":93,"type":91},"2025-07-23",{"date":95,"type":78},"2026-08-23",{"name":5,"class":6},1]