[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638981":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":58,"collaborators":24,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":24,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":85,"whyStopped":24,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Guided Bone Regeneration with ADM (AlloDerm) as a barrier","EXPERIMENTAL","GBR will be performed using a composite particulate graft consisting of a combination of freeze-dried bone allograft (FDBA) and xenograft in a 75%\u002F25% mixture. Following decortication and graft placement to reconstruct the horizontal ridge deficiency, acellular dermal matrix (ADM) will be adapted to fully cover the augmented site with appropriate extension beyond the defect margins. The ADM will be stabilized using titanium tacks and\u002For periosteal sutures as needed to ensure space maintenance and membrane stability.",[13],"Procedure: Guided Bone Regeneration with ADM (AlloDerm) as a barrier",{"label":15,"type":16,"description":17,"interventionNames":18},"Guided Bone Regeneration with Resorbable Crosslinked Collagen Matrix (Mem-Lok) as a barrier","ACTIVE_COMPARATOR","GBR will be performed using a composite particulate graft consisting of a combination of freeze-dried bone allograft (FDBA) and xenograft in a 75%\u002F25% mixture. The graft will be contoured to reconstruct the horizontal ridge deficiency following decortication of the recipient site. A resorbable collagen membrane \\[Mem-Lok® Resorbable Collagen Matrix (RCM) will be trimmed and positioned to fully cover the grafted area with extension beyond the defect margins and stabilized using titanium tacks and\u002For periosteal sutures as needed.",[19],"Procedure: Guided Bone Regeneration with Resorbable Crosslinked Collagen Matrix (Mem-Lok) as a barrier",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"PROCEDURE",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"affiliation":5,"role":30},"Maria L Geisinger, DDS, MS","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":24,"email":36},"Maria Geisinger, DDS, MS","CONTACT","205-934-4984","miagdds@uab.edu",{"name":38,"role":34,"phone":39,"phoneExt":24,"email":40},"Sarah Startley, DMD","205-975-8711","ss1971@uab.edu",[42],{"facility":5,"status":24,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Birmingham","Alabama","35294","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-86.80249,33.52066,{"lat":52,"lon":51},[55,56,57],{"name":33,"role":34,"phone":35,"phoneExt":24,"email":36},{"name":38,"role":34,"phone":39,"phoneExt":24,"email":40},{"name":33,"role":30,"phone":24,"phoneExt":24,"email":24},{"type":30,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Maria L. Geisinger, DDS, MS","Chair, Professor","100638981","evaluating-the-barrier-function-regenerative-capacity-and-soft-tissue-outcomes-of-acellular-dermal-matrix-100638981",false,"NCT07613047","Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix","A Prospective, Double-Arm, Randomized Controlled Trial Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix Compared to Resorbable Collagen Membranes in Edentulous Ridge Augmentation","Inclusion Criteria:\n\n* English speaking\n* At least 18 years old\n* Must be a patient of the UAB Dental School\n* Able to read and understand informed consent document\n* Patients presenting with a diagnosed need horizontal ridge augmentation with GBR without simultaneous implant placement, to allow for future dental implant placement.\n* Presence of periodontally healthy, non-carious neighboring teeth and\u002For healthy restored dental implants on either side of the edentulous span planned for GBR, or unhealthy adjacent teeth to be extracted during the same visit.\n* ≤4 mm ridge width in a Seibert Class I Edentulous span19\n* No anticipated need for surgical and\u002For endodontic care at planned teeth adjacent to the proposed surgical site during the study period.\n\nExclusion Criteria:\n\n* Non-English speaking\n* Less than 18 years old\n* Smokers\u002Fnicotine users (defined as currently reporting use of any form of tobacco\u002Fnicotine products)\n* Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing, including:\n\n  * Uncontrolled diabetes (HbA1c \\> 7%)\n  * Untreated periodontal disease\n  * History of head\u002Fneck radiation\n  * IV bisphosphonates\n  * Immunocompromised state\n  * Pregnancy\n  * Acute infection at site\n* Documented or suspected allergy or sensitivity to any study product",true,"ALL","18 Years","85 Years",{"count":73,"type":74},70,"ESTIMATED","INTERVENTIONAL",[77],"NA","This investigator-initiated study will compare ADM and resorbable cross-linked collagen membrane barriers for guided bone regeneration at atrophic lateral ridge augmentation sites.",[80,81,82],"Acellular Dermal Matrix","Bone Grafting","Soft Tissue Grafting",[84],"soft tissue graft","NOT_YET_RECRUITING","2026-05-28",{"date":88,"type":89},"2026-06-01","ACTUAL",{"date":91,"type":74},"2026-10",{"date":93,"type":74},"2028-10",{"name":5,"class":6},1]