[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100539319":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":35,"locations":41,"responsibleParty":58,"collaborators":23,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":23,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":23,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":23,"overallStatus":44,"whyStopped":23,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Hama University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"injectable form of PRF","EXPERIMENTAL","A group of patients in which participants will be undergo to orthodontic treatment will be received a 0.9 ml injection of PRF after 1st premolar extraction.",[13],"Device: injectable form of PRF",{"label":15,"type":10,"description":16,"interventionNames":17},"traditional orthodontic treatment","A group of patients in which participants will be undergo to traditional orthodontic treatment will be received a Placebo injection after 1st premolar extraction.",[18],"Behavioral: Placebo injection",[20,24],{"type":21,"name":9,"description":11,"armGroupLabels":22,"otherNames":23},"DEVICE",[9],null,{"type":25,"name":26,"description":16,"armGroupLabels":27,"otherNames":23},"BEHAVIORAL","Placebo injection",[15],[29,32],{"name":30,"affiliation":5,"role":31},"Eisa Salami, MSc student","PRINCIPAL_INVESTIGATOR",{"name":33,"affiliation":5,"role":34},"Rabab Alsabbagh, Professor","STUDY_CHAIR",[36],{"name":37,"role":38,"phone":39,"phoneExt":23,"email":40},"FADI JNAID, Associate Professor","CONTACT","988499015","Drfadijnaid@gmail.com",[42],{"facility":43,"status":44,"city":45,"state":23,"zip":23,"country":46,"countryCode":23,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Fadi Jnaid","RECRUITING","Hama","Syria",{"type":48,"coordinates":49},"Point",[50,51],36.75783,35.13179,{"lat":51,"lon":50},[54,56],{"name":55,"role":38,"phone":23,"phoneExt":23,"email":40},"Fadi Jnaid, Associate Professor",{"name":23,"role":38,"phone":57,"phoneExt":23,"email":23},"0988499015",{"type":31,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"FADI JNAID","Syria-Hama University","100539319","evaluating-the-effect-of-injectable-platelet-rich-fibrin-on-accelerating-orthodontic-tooth-movement-100539319",false,"NCT06302296","Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement","Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement During Leveling and Alignment Stage Study Description","Inclusion Criteria:\n\n* The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar.\n\n  * Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern.\n  * All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position.\n  * The patient has good oral health.\n\nExclusion Criteria:\n\n* • The presence of any systemic disease that affects orthodontic dental movement.\n\n  * Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar).\n  * The patient has undergone previous orthodontic treatment.\n  * The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs).\n  * The patient has poor oral health.\n  * Commitment to periodic follow-up appointments.","ALL","18 Years","26 Years",{"count":72,"type":73},14,"ESTIMATED","INTERVENTIONAL",[76],"NA","One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize.",[79,80],"Tooth Mobility","Injectable Platelet-rich Fibrin","2025-09-09",{"date":83,"type":84},"2025-09-15","ACTUAL",{"date":86,"type":73},"2025-12-20",{"date":88,"type":73},"2026-07-15",{"name":5,"class":6},1]