[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633839":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":59,"collaborators":61,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Montana","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dosimeter-Controlled Cough Reflex Sensitivity Testing","ACTIVE_COMPARATOR","Participants will undergo cough reflex sensitivity testing using a dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) to deliver aerosolized citric acid.",[13],"Device: Cosmed QuarkSpiro Dosimeter-Controlled Nebulizer",{"label":15,"type":16,"description":17,"interventionNames":18},"Handheld Nebulizer Cough Reflex Sensitivity Testing","EXPERIMENTAL","Participants will undergo cough reflex sensitivity testing using a handheld nebulizer (DeVilbiss 45) to deliver aerosolized citric acid.",[19],"Device: DeVilbiss 45 Handheld Nebulizer",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Cosmed QuarkSpiro Dosimeter-Controlled Nebulizer","Laboratory spirometry system equipped with a dosimeter-controlled nebulizer used to deliver standardized aerosolized citric acid during cough challenge testing.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"DeVilbiss 45 Handheld Nebulizer","Commercial handheld nebulizer used to deliver aerosolized citric acid during cough challenge testing.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Jane E Salois, PhD","CONTACT","406-243-2138","jane.salois@umontana.edu",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Laurie J Slovarp, PhD","406-243-2107","laurie.slovarp@umontana.edu",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Missoula","Montana","59812","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-113.994,46.87215,{"lat":53,"lon":52},[56,57],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"name":33,"role":58,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":60,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[62],{"name":63,"class":64},"National Institute of General Medical Sciences (NIGMS)","NIH","100633839","evaluating-the-feasibility-and-reliability-of-using-handheld-nebulizers-to-conduct-cough-sensitivity-testing-with-citric-acid-100633839",false,"NCT07531901","Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid","Inclusion Criteria:\n\n* Healthy adults at least 18 years of age\n* Consent to audio\u002Fvideo recording of the research sessions for research purposes\n* Spirometry testing results obtained by study team on same day of first testing session with FEV1\u002FFVC ratio and FEV1 percent predicted values of at least 0.70\n\nExclusion Criteria:\n\n* Pregnant or trying to become pregnant (if capable of becoming pregnant- a urine pregnancy test will be provided onsite and a negative result must be obtained prior to the first testing session)\n* Smoking of any substance in the last six months\n* Diagnosed or suspected pulmonary disease (e.g., asthma, COPD)\n* History of chronic cough\n* History of head or neck cancer\n* History of neurological disease (e.g., cerebrovascular accident)\n* History of dysphagia (swallowing difficulty)\n* Current complaint of a voice problem\n* Current upper respiratory infection",true,"ALL","18 Years","89 Years",{"count":76,"type":77},10,"ESTIMATED","INTERVENTIONAL",[80],"NA","Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.",[83],"Cough Reflex Sensitivity",[85,86],"cough challenge testing","cough reflex sensitivity testing","2026-06-01",{"date":89,"type":90},"2026-06-03","ACTUAL",{"date":92,"type":77},"2026-06-05",{"date":94,"type":77},"2027-02-28",{"name":5,"class":6},1]