[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606294":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":18,"collaborators":10,"id":22,"slug":23,"hasResults":24,"nctId":25,"briefTitle":26,"officialTitle":26,"acronym":10,"eligibilityCriteria":27,"healthyVolunteers":24,"sex":28,"minAge":29,"maxAge":30,"enrollmentInfo":31,"targetDuration":10,"studyType":34,"phases":10,"briefSummary":35,"conditions":36,"keywords":10,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Group 1",null,"diabetic patients without diabetic nephropathy (albumin\u002Fcreatinine ratio: \\\u003C 30 mg alb\u002Fgm creatinine )",{"label":13,"type":10,"description":14,"interventionNames":10},"Group2","diabetic patients with first stage diabetic nephropathy ( albumin\u002Fcreatinine ratio: 30-300 mg alb\u002Fgm creatinine)",{"label":16,"type":10,"description":17,"interventionNames":10},"Group 3","diabetic patients with second stage diabetic nephropathy (albumin\u002Fcreatinine ratio \\>300 mg alb\u002Fgm creatinine)",{"type":19,"investigatorFullName":20,"investigatorTitle":21,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Naira Ali Mohammed Soliman","residant doctor","100606294","evaluating-the-roles-of-novel-inflammatory-markers-compared-to-mcp-1-in-type-2-diabetic-nephropathy-100606294",false,"NCT07173686","Evaluating The Roles of Novel Inflammatory Markers Compared to MCP-1 in Type 2 Diabetic Nephropathy","Inclusion Criteria:\n\n* Adult aged 18-80 years, both genders.\n* clear history of T2DM\n\nExclusion Criteria:\n\n* Kidney disease caused by any other causes\n* Estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin\u002F1.73 - m2\n* Existing obvious infection\n* Acute stage of cardiovascular or cerebrovascular diseases\n* Acute complications of diabetes recently (such as diabetic ketoacidosis, et al.)\n* Associated malignant tumors\n* Hematological system, and autoimmune system diseases","ALL","18 Years","80 Years",{"count":32,"type":33},80,"ESTIMATED","OBSERVATIONAL","Diabetic kidney disease (DKD) is one of the most common microvascular complications of type 2 diabetes mellitus (T2DM), affecting up to 40% of diabetic patients and accounting for the leading cause of end-stage renal disease worldwide \\[1\\]. The progression of DKD involves multiple mechanisms, including oxidative stress, endothelial dysfunction, and most importantly, chronic inflammation \\[2\\].\n\nSystemic inflammation plays a central role in renal injury by promoting glomerular and tubulointerstitial damage. the neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory index (SII) has emerged as a readily accessible markers of subclinical inflammation. Elevated NLR and SII levels have been significantly associated with increased urinary albumin excretion and decreased estimated glomerular filtration rate (eGFR) in T2DM patients \\[3\\]. It was demonstrated that patients in the highest NLR tertile had a higher prevalence of DKD, independent of confounders \\[4\\].\n\nHigh-sensitivity C-reactive protein (hsCRP), is widely used to evaluate systemic inflammation. Recent studies have shown a strong association between elevated hsCRP levels and DKD development \\[5\\].Some studies provided genetic evidence supporting a causal relationship between higher hsCRP and diabetic nephropathy \\[6\\].\n\nMonocyte chemoattractant protein-1 (MCP-1) is a chemokine involved in monocyte recruitment to inflamed renal tissues. Elevated serum and urinary MCP-1 levels have been found to predict microalbuminuria and eGFR decline in T2DM patients \\[7,8\\].\n\nIdentifying these markers may help in early diagnosis, risk stratification, and monitoring progression of DKD.",[37],"Diabetic Nephropathy","NOT_YET_RECRUITING","2025-09-08",{"date":41,"type":42},"2025-09-15","ACTUAL",{"date":44,"type":33},"2025-10-01",{"date":46,"type":33},"2026-11-01",{"name":5,"class":6}]