[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634677":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":30,"locations":36,"responsibleParty":50,"collaborators":19,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":19,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":75,"overallStatus":85,"whyStopped":19,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Cairo University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"CGF Plug Intervention Group","EXPERIMENTAL","This arm involves patients requiring simple, non-surgical extraction of a single tooth. Following an atraumatic extraction and socket curettage, a Concentrated Growth Factor (CGF) plug is packed into the fresh odontectomy site. The CGF plug is prepared by centrifuging 10 mL of the patient's own blood using a specialized variable-speed protocol to create a dense fibrin matrix. After the plug is inserted, the wound is secured with Vicryl sutures. Participants in this arm are evaluated for changes in bone density via CBCT imaging and for postoperative pain using the Verbal Numeric Rating Scale (VNRS).",[13],"Other: Concentrated Growth Factor (CGF) Plug",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Concentrated Growth Factor (CGF) Plug","The intervention involves preparing an autologous Concentrated Growth Factor (CGF) plug from the patient's blood using variable-speed centrifugation and placing it into a fresh, curetted extraction socket to evaluate its impact on bone density and postoperative pain.",[9],null,[21,24,27],{"name":22,"affiliation":5,"role":23},"Hisham Sayed, Professor","STUDY_CHAIR",{"name":25,"affiliation":5,"role":26},"Abdelmoez Mohamed El-Sharkawy, Associate Professor","STUDY_DIRECTOR",{"name":28,"affiliation":5,"role":29},"Aziz Taysir Haydar","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","+201080823761","+966550484556","Zizoaziz66@gmail.com",[37],{"facility":38,"status":19,"city":39,"state":19,"zip":19,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Cairo University Faculty of Dentistry","Cairo","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],31.24967,30.06263,{"lat":46,"lon":45},[49],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},{"type":29,"investigatorFullName":28,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Principal Investigator","100634677","evaluating-the-use-of-cgf-plugs-in-fresh-odontectomy-socket-100634677",false,"NCT07542795","Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.","Clinical and Radiographic Evaluation of the Use of CGF Plugs Packed in Fresh Odontectomy Socket (Case Series Study)","CGF","Inclusion Criteria:\n\n* Systemically healthy patients (ASA I or II)\n* Age between 20 and 50 years\n* Require simple, non-surgical extraction of a single tooth\n* Presence of periapical radiolucency at the extraction site\n* Willingness to comply with follow-up and provide signed informed consent\n\nExclusion Criteria:\n\n* • Systemic diseases (e.g., uncontrolled diabetes, bone metabolic disorders)\n\n  * History of radiotherapy or chemotherapy\n  * Use of medications affecting bone metabolism (e.g., bisphosphonates, chronic steroids)\n  * Heavy smokers\n  * Pregnant or lactating women\n  * Poor oral hygiene or active acute infection\u002Fsuppuration at the site","ALL","20 Years","50 Years",{"count":64,"type":65},10,"ESTIMATED","INTERVENTIONAL",[68],"NA","This study evaluates the use of Concentrated Growth Factor (CGF) plugs-a third-generation healing material made from the patient's own blood-to improve recovery after simple tooth extractions. CGF contains a dense matrix of growth factors and regenerative cells designed to enhance wound healing and tissue regeneration.\n\nParticipants requiring a single, non-surgical tooth extraction will have a CGF plug placed into the empty socket immediately following the procedure. The researchers will then monitor two main factors:\n\n* Post-operative Pain: Patients will record their pain levels on a scale of 0 to 10 at 1, 3, and 7 days after the extraction.\n* Bone Density: Using specialized imaging (CBCT), the researchers will measure how well the bone heals and fills the socket immediately after the procedure and again at 3 months.\n\nThe goal of this research is to determine if CGF plugs can effectively reduce patient discomfort and help preserve bone density, which is critical for future dental treatments like implants.",[71,72,73,74],"Odontectomy (Tooth Extraction)","Socket Preservation and Healing Following Simple, Non-surgical Extraction","Alveolar Bone Density and Postoperative Pain Management","Periapical Radiolucency",[76,77,78,79,80,81,82,83,84],"Concentrated Growth Factor (CGF)","CGF Plug","Odontectomy","Tooth Extraction","Socket Preservation","Bone Density","Postoperative Pain","Alveolar Bone","Platelet Concentrates","NOT_YET_RECRUITING","2026-04-15",{"date":88,"type":89},"2026-04-21","ACTUAL",{"date":91,"type":65},"2026-09-28",{"date":93,"type":65},"2026-12-30",{"name":5,"class":6},1]