[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633638":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":27,"locations":36,"responsibleParty":55,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":10,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Male Infertility Patients with OAT Syndrome",null,"* Men aged 18 to 60 years who are diagnosed with male infertility and present with Oligoasthenoteratozoospermia (OAT) syndrome. According to the World Health Organization (WHO) standards, OAT is defined by the following concurrent semen parameters:\n\n  * Oligozoospermia: Sperm concentration \\\u003C 15 million\u002FmL or total sperm count \\\u003C 39 million.\n  * Asthenozoospermia: Progressive motility \\\u003C 32%.\n  * Teratozoospermia: Normal morphology \\\u003C 4%.\n* Participants are recruited from the Department of Andrology at Binh Dan Hospital, Ho Chi Minh City. The study excludes individuals with:\n\n  * Genetic or chromosomal abnormalities (e.g., Klinefelter syndrome, XYY syndrome).\n  * Structural abnormalities of the reproductive organs.\n  * Azoospermia (no sperm in the ejaculate).\n  * Recent use (within the last 3 months) of medications known to affect spermatogenesis, such as anabolic steroids or certain calcium channel blockers.\n  * Inability to communicate or participate in the survey.",[13,16,19,22,24],{"name":14,"affiliation":5,"role":15},"Thi-Bay Nguyen, PhD","STUDY_CHAIR",{"name":17,"affiliation":5,"role":18},"Minh-Man Pham Bui, PhD","STUDY_DIRECTOR",{"name":20,"affiliation":21,"role":18},"Tien-Dung Ba Mai, PhD","Binh Dan Hospital",{"name":23,"affiliation":5,"role":18},"Kim-Oanh Thi Ngo",{"name":25,"affiliation":5,"role":26},"Dai-Nhan Tran, Medical Doctor","PRINCIPAL_INVESTIGATOR",[28,32],{"name":17,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","+84916080803","bpmman@uhsvnu.edu.vn",{"name":33,"role":29,"phone":34,"phoneExt":10,"email":35},"Dai-Nhan Tran, Medical doctor","+84773478145","nhantd97@gmail.com",[37],{"facility":21,"status":38,"city":39,"state":39,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Ho Chi Minh City","Vietnam","VN",{"type":43,"coordinates":44},"Point",[45,46],106.62965,10.82302,{"lat":46,"lon":45},[49,53,54],{"name":50,"role":29,"phone":51,"phoneExt":10,"email":52},"Tien-Dung Mai Ba, PhD","+84913809110","maibatiendung@yahoo.com",{"name":25,"role":29,"phone":34,"phoneExt":10,"email":35},{"name":25,"role":26,"phone":10,"phoneExt":10,"email":10},{"type":26,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Bui Pham Minh Man","Investigator","100633638","evaluating-traditional-medicine-syndromes-in-male-infertility-with-oligoasthenoteratozoospermia-100633638",false,"NCT07529288","Evaluating Traditional Medicine Syndromes in Male Infertility With Oligoasthenoteratozoospermia","Characterization of Traditional Medicine Syndromes in Male Infertility With Oligoasthenoteratozoospermia Via Latent Tree Models","Inclusion Criteria:\n\n* Male patients aged between 18 and 60 years.\n* Diagnosed with male infertility by an andrology specialist according to World Health Organization (WHO) standards.\n* Semen analysis results meet the diagnostic criteria for Oligoasthenoteratozoospermia (OAT) syndrome.\n* Voluntary agreement to participate in the research and signed Informed Consent Form.\n\nExclusion Criteria:\n\n* Infertility caused by genetic or chromosomal abnormalities, including but not limited to: Klinefelter syndrome, Sandberg mosaic syndrome (46 XY\u002F47 XXY), or XYY syndrome.\n* Presence of structural abnormalities of the reproductive organs.\n* Patients with Azoospermia (absence of sperm in the ejaculate) as defined by WHO 2021 standards.\n* Use of medications affecting spermatogenesis within the last 3 months, including: cannabinoids, hydantoins, valproate, anabolic steroids, cimetidine, colchicine, spironolactone, nitrofurantoin, sulfasalazine, or calcium channel blockers.\n* Inability to understand or answer survey questions due to physical or mental limitations (e.g., mutism, deafness, intellectual disability, coma, or being on a ventilator in the ICU).\n* Lack of cooperation during the clinical examination and interview process.","MALE","18 Years","60 Years",{"count":69,"type":70},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to identify and evaluate the characteristics of Traditional Medicine (TM) syndromes in men aged 18 to 60 with male infertility and oligoasthenoteratozoospermia (OAT) syndrome. The main questions it aims to answer are:\n\n* What are the common Traditional Medicine syndromes and symptoms associated with male infertility based on Traditional Medicine literature?\n* What are the specific Traditional Medicine syndromes and symptoms found in men with OAT syndrome at Binh Dan Hospital when analyzed using Latent Tree Models?\n\nThe research will be conducted in two phases:\n\n* Phase 1 (Literature Review): Researchers will collect and analyze Traditional Medicine texts to list the symptoms and syndromes related to male infertility. This phase will help create a standardized clinical survey.\n* Phase 2 (Clinical Survey): Researchers will recruit 300 male participants with OAT syndrome.\n\n  * Participants will answer a survey questionnaire about their Traditional Medicine symptoms.\n  * Researchers will apply Latent Tree Models (a mathematical approach) to the collected data to objectively classify the TM syndromes.",[74],"Male Infertility With OAT",[76,77,78,79],"Traditional Medicine Pattern","OAT","Male Infertility","Oligoasthenoteratozoospermia","2026-04-09",{"date":82,"type":83},"2026-04-14","ACTUAL",{"date":85,"type":83},"2026-01-14",{"date":87,"type":70},"2026-09-30",{"name":5,"class":6},1]