[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565474":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":52,"responsibleParty":75,"collaborators":30,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":30,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":30,"enrollmentInfo":88,"targetDuration":30,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":55,"whyStopped":30,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Ente Ospedaliero Cantonale, Bellinzona","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"study intervention with spinal anesthesia composed by local anesthetic, morphine and no fentanyl","ACTIVE_COMPARATOR","Every patient will receive, before induction of general anesthesia as in control group, a spinal anesthesia composed by hyperbaric bupivacaine 5 mg 0,5% and morphine sulfate 100 mcg.",[13],"Procedure: General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and no fentanyl)",{"label":15,"type":10,"description":16,"interventionNames":17},"study intervention with spinal anesthesia composed by local anesthetic, morphine and 20 mcg fentanyl","every patient will receive, before induction of general anesthesia, as in the control group, a spinal anesthesia composed by hyperbaric bupivacaine 5 mg 0,5%, morphine sulfate 100 mcg and fentanyl 20 mcg.",[18],"Procedure: General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and 20 mcg fentanyl)",{"label":20,"type":10,"description":21,"interventionNames":22},"study intervention NO spinal","Every patient will receive a general anesthesia induced with propofol (1.5-2.5 mg\u002Fkg, individually adjusted), rocuronium (0.6 mg\u002Fkg) for muscle relaxation and a continuous infusion of remifentanil (0.05-0.3 mcg\u002Fkg\u002Fmin, depending on the clinical characteristics of the patient). General anesthesia was maintained with a continuous infusion of propofol (4-8 mg\u002Fkg\u002Fh), and the infusion of remifentanil which was started with the induction. Fractionated doses of rocuronium were administered based on TOF monitoring (train of four) to maintain muscle relaxation.",[23],"Procedure: General Anesthesia (control group)",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","General Anesthesia (control group)","Only General Anestesia",[20],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and no fentanyl)","General anesthesia + spinal anesthesia with local anesthetic and morfine",[9],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and 20 mcg fentanyl)","General anesthesia + spinal anesthesia with local anesthetic, morfine and fentanyl",[15],[40],{"name":41,"affiliation":5,"role":42},"Andrea Saporito, Anesth","STUDY_CHAIR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},"Roberto Dossi, Anesth","CONTACT","0041 (0)918119341","roberto.dossi@eoc.ch",{"name":41,"role":46,"phone":50,"phoneExt":30,"email":51},"0041 (0)918118978","andrea.saporito@eoc.ch",[53,66],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":57,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":30},"Ente Ospedaliero Cantonale ORBV","RECRUITING","Bellinzona","Switzerland","6500","CH",{"type":61,"coordinates":62},"Point",[63,64],9.01703,46.19278,{"lat":64,"lon":63},{"facility":67,"status":68,"city":56,"state":57,"zip":58,"country":57,"countryCode":59,"cosmosGeoPoint":69,"geoPoint":71,"contacts":72},"Ente Ospedaliero Cantonale, Ospedale Regionale di Bellinzona e Valli","NOT_YET_RECRUITING",{"type":61,"coordinates":70},[63,64],{"lat":64,"lon":63},[73],{"name":45,"role":46,"phone":74,"phoneExt":30,"email":48},"0041(0)918119341",{"type":76,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"SPONSOR_INVESTIGATOR","Andrea Saporito","Head of Anesthesiology, Prof.Dr.Med.","100565474","evaluation-and-comparison-between-general-anesthesia-vs-two-types-of-combined-anesthesia-for-opioid-consumption-in-laparoscopic-hysterectomy-100565474",false,"NCT06642649","Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia for Opioid Consumption in Laparoscopic Hysterectomy","Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia (general and Spinal Anesthesia) for Opioid Consumption in Laparoscopic Hysterectomy: a Multi-Center, Randomized, Prospective, Controlled Trial","Inclusion Criteria:\n\n* patients over 18 year of age,\n* ASA physical status I to III scheduled for laparoscopic hysterectomy (with or without adnexectomy)\n\nExclusion Criteria:\n\n* patients with inability to consent,\n* patient refusal,\n* contraindication to spinal anesthesia (e.g., hemodynamic instability, infection at the surgery site, and neurologic defects such as transverse myelitis, coagulopathies or ongoing anticoagulant therapy),\n* known chronic pain syndrome, known\n* suspected non- compliance,\n* drug, or alcohol abuse ,\n* major oncological surgeries,\n* allergy to drugs used in the protocol,\n* previous chronic use of analgesics\n* history of opioid abuse","FEMALE","18 Years",{"count":89,"type":90},45,"ESTIMATED","INTERVENTIONAL",[93],"NA","The aim of the study is to evaluate and compare general anesthesia VS two types of combined anesthesia in opioid consumption after laparoscopic hysterectomy",[96,97],"Laparoscopic Hysterectomy","Gynecology",[99,100,101],"laparoscopic hysterectomy","spinal anesthesia","general anesthesia","2025-02-26",{"date":104,"type":105},"2025-02-28","ACTUAL",{"date":107,"type":105},"2024-11-01",{"date":109,"type":90},"2026-04-30",{"name":77,"class":6},2]