[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586312":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":80,"collaborators":82,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":87,"sex":93,"minAge":94,"maxAge":26,"enrollmentInfo":95,"targetDuration":26,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":107,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"AddiPsy","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"GPM-Extended group (ADDIPSY, Lyon, France)","EXPERIMENTAL","Participants receive a one-year outpatient treatment based on GPM-extended, a dimensional adaptation of Good Psychiatric Management for BPD. It includes weekly 1-hour individual therapy focused on dominant personality dilemmas (abandonment, self-esteem, control), guided by structured clinical and psychometric assessment. Psychiatric case management (30 min every 3 weeks) addresses medication and coordination of care. Group components include at least one 6-week psychoeducation program (borderline, narcissistic, or obsessive-compulsive focus) and, for high emotion dysregulation, an 18-week DBT skills training group.",[13],"Behavioral: GPM-Extended",{"label":15,"type":16,"description":17,"interventionNames":18},"Classic GPM (Clinique CARADOC, Bayonne, France)","ACTIVE_COMPARATOR","Participants receive a one-year outpatient treatment based on classic Good Psychiatric Management (GPM) for BPD. It includes weekly 1-hour individual therapy focused on interpersonal hypersensitivity, delivered by a GPM-trained therapist. Psychiatric case management (30 min every 3 weeks) addresses medication and coordination of care. Group interventions include a 6-week psychoeducation group on BPD and, for patients with high emotion dysregulation, an 18-week DBT skills training group.",[19],"Behavioral: Classic GPM",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","GPM-Extended","GPM-extended is a dimensional adaptation of Good Psychiatric Management (GPM) that retains its core principles-validation, real-life focus, alliance building-while enhancing flexibility and personalization. It emphasizes diagnostic clarity, treatment prioritization, and individualized psychoeducation based on three key personality dilemmas: fear of abandonment, self-esteem dysregulation, and control dependency. These dilemmas guide the focus of therapy and case management. Treatment goals are collaboratively set and regularly reassessed to align with the patient's evolving needs. The intervention includes weekly individual therapy and tailored group programs, with clinical strategies adapted to each dominant dilemma.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Classic GPM","The classic GPM group follows the validated and manualized version of Good Psychiatric Management (GPM) for BPD. It emphasizes symptom stabilization through weekly individual therapy and pragmatic case management every 3 weeks. Unlike GPM-extended, it uses a uniform therapeutic framework rather than tailoring treatment to individual personality dilemmas,.The intervention includes weekly individual therapy and standardized group programs, with clinical strategies applied uniformly across patients, centered on interpersonal hypersensitivity and building stable life roles.",[15],[32],{"name":33,"affiliation":5,"role":34},"Martin Blay, M.D., M.Sc","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+33472943403","m.blay@addipsy.com",{"name":41,"role":37,"phone":38,"phoneExt":26,"email":42},"Frédéric Mazenod","f.mazenod@santebasque.fr",[44,67],{"facility":45,"status":46,"city":47,"state":26,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Clinique Caradoc","RECRUITING","Bayonne","64100","France","FR",{"type":52,"coordinates":53},"Point",[54,55],-1.473,43.49316,{"lat":55,"lon":54},[58,62,65],{"name":59,"role":37,"phone":60,"phoneExt":26,"email":61},"François Chevrier, M.D.","+33559441744","f.chevrier@caradoc.fr",{"name":63,"role":37,"phone":60,"phoneExt":26,"email":64},"Linda Portilla","dpo@caradoc.fr",{"name":59,"role":66,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"facility":68,"status":46,"city":69,"state":26,"zip":70,"country":49,"countryCode":50,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Addipsy","Lyon","69007",{"type":52,"coordinates":72},[73,74],4.84789,45.74906,{"lat":74,"lon":73},[77,78,79],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},{"name":41,"role":37,"phone":38,"phoneExt":26,"email":42},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"type":81,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[83],{"name":45,"class":84},"UNKNOWN","100586312","evaluation-of-a-dimensional-adaptation-of-good-psychiatric-management-gpm-extended-for-the-treatment-of-borderline-personality-disorder-100586312",false,"NCT06913738","Evaluation of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) for the Treatment of Borderline Personality Disorder","A Pragmatic Non-randomized Controlled Study Evaluating the Efficacy of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) Compared to a Classic Outpatient Good Psychiatric Management Treatment for Patient Fulfilling Criteria for Borderline Personality Disorder","EPSYLIA","Inclusion Criteria:\n\n* Adults (≥18 years old)\n* Diagnosis of borderline personality disorder according to the SCID-II (≥5 out of 9 criteria)\n* Provision of written informed consent\n* Affiliated with or beneficiary of the French national health insurance system\n\nExclusion criteria\n\n* Age under 18 years\n* Presence of a comorbid psychotic disorder, intellectual disability, severe antisocial traits, major substance use disorder incompatible with intensive therapy without abstinence, anorexia nervosa with somatic risk, or bipolar disorder in acute manic phase\n* Individuals under legal protection (e.g., guardianship or legal safeguard)\n* Individuals unable to cooperate or complete self- or clinician-administered questionnaires\n* Individuals not affiliated with or not beneficiaries of the French national health insurance system","ALL","18 Years",{"count":96,"type":97},154,"ESTIMATED","INTERVENTIONAL",[100],"NA","The goal of this clinical trial is to evaluate whether a dimensional adaptation of Good Psychiatric Management (called GPM-extended) is more effective than classic Good Psychiatric Management (GPM) in treating adult patients with borderline personality disorder (BPD). Briefly, the GPM-extended model integrates elements from existing adaptations of GPM for narcissistic and obsessive-compulsive personality disorders. It aims to provide a more personalized and dimensional approach to treatment, tailored to each patient's specific personality dysfunction and interpersonal triggers.\n\nThe main questions it aims to answer are:\n\n* Does GPM-extended improve overall BPD symptom severity more than classic GPM after one year of treatment?\n* Does GPM-extended lead to better outcomes in related clinical domains (e.g., personality functioning, emotional regulation, social functioning...) ?\n\nResearchers will compare two groups:\n\n* Patients treated in a center using the GPM-extended program.\n* Patients treated in a center using the classic GPM program. In each group, patients will receive weekly outpatient psychiatric care for one year.\n\nIn terms of evaluation, patients will be evaluated at baseline, 4 months, 8 months, and 1 year. They will undergo both clinician-administered and self-report assessments to measure BPD symptoms and other relevant psychological dimensions.\n\nThis study hopes to contribute to the development of dimensional evidence-based treatments for personality disorders.",[103,104,105,106],"Borderline Personality Disorder","Narcissism","Obsessive Compulsive Personality Disorder","Personality Disorder",[108,109,110,111,112],"Personality disorder","borderline personality disorder","good psychiatric management","psychotherapy","dimensional","2025-04-07",{"date":115,"type":116},"2025-04-09","ACTUAL",{"date":118,"type":116},"2024-06-19",{"date":120,"type":97},"2029-12",{"name":5,"class":6},2]