[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641956":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":24,"centralContacts":34,"locations":40,"responsibleParty":56,"collaborators":24,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":24,"overallStatus":43,"whyStopped":24,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Split, School of Medicine","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Active treatment","EXPERIMENTAL","One forearm will be treated with the peptide-based cream containing Acetyl Hexapeptide-37. The treated forearm (left or right) will be assigned according to the randomization protocol.",[13],"Other: Acetyl Hexapeptide-37",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo treatment","PLACEBO_COMPARATOR","The other forearm will be treated with a placebo ointment. The allocation of the treatment (left or right forearm) will be determined according to the randomization protocol.",[19],"Other: Placebo",{"label":21,"type":22,"description":23,"interventionNames":24},"Untreated Control Site","NO_INTERVENTION","A designated skin site on either forearm will undergo tape-stripping to induce skin barrier disruption but will not receive any topical treatment. This site will serve as a control for natural skin barrier recovery.",null,[26,30],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":24},"Acetyl Hexapeptide-37","The emollient cream contains Acetyl Hexapeptide-37 as the active ingredient and is applied topically to designated skin areas on the forearm. Skin barrier disruption is induced prior to application using the tape-stripping method. Procedure will be performed on healthy, intact skin according to randomization protocol",[9],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":24},"Placebo","The emollient cream without the peptide is applied topically to designated skin areas on the forearm. Skin barrier disruption is induced prior to application using the tape-stripping method. Procedure will be performed on healthy, intact skin according to randomization protocol",[15],[35],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Josipa Bukić","CONTACT","+385917933753","jbukic@mefst.hr",[41],{"facility":42,"status":43,"city":44,"state":24,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University of Split School of Medicine","RECRUITING","Split","21000","Croatia","HR",{"type":49,"coordinates":50},"Point",[51,52],16.43915,43.50891,{"lat":52,"lon":51},[55],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},{"type":57,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100641956","evaluation-of-a-peptide-cream-on-the-forearm-skin-recovery-of-healthy-volunteers-100641956",false,"NCT07614698","Evaluation of a Peptide Cream on the Forearm Skin Recovery of Healthy Volunteers","Evaluation of the Efficacy of a Topical Formulation Containing Acetyl Hexapeptide-37 on Skin Barrier Recovery of the Forearm After Controlled Damage Using the Tape-stripping Method","Inclusion Criteria:\n\n* healthy volunteers who gave written informed consent\n\nExclusion Criteria:\n\n* skin disease\n* skin damage on measurement sites\n* use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial\n* use of emollients three days prior the inclusion in the trial\n* non-adherence to the trial protocol\n* exposure to artificial and excessive natural ultraviolet (UV) radiation\n* pregnancy or breastfeeding\n* immunosuppression\n* allergic or irritant reactions to the constituents of the cream",true,"ALL","18 Years","50 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this clinical trial is to evaluate the efficacy of a topical peptide-based formulation containing Acetyl Hexapeptide-37 in promoting skin barrier recovery after controlled disruption in healthy adult participants.\n\nThe main questions it aims to answer are:\n\n* Does the peptide cream speed up the recovery of the skin barrier after it has been slightly damaged with tape-stripping method?\n* How does the peptide cream compare to a placebo (a cream with no active ingredient) in improving skin hydration and reducing redness?\n\nResearchers will compare the peptide cream to a placebo to assess its effects on skin barrier recovery\n\nParticipants will:\n\n* Undergo controlled disruption of the skin barrier on the volar forearm using the tape-stripping method.\n* One forearm will receive the peptide-based cream containing Acetyl Hexapeptide-37, while the other (contralateral) forearm will receive a placebo formulation.\n* Attend scheduled visits for non-invasive assessments of skin barrier function, including transepidermal water loss, skin hydration, and erythema",[77],"Skin Barrier Disruption and Recovery","2026-06-15",{"date":80,"type":81},"2026-06-17","ACTUAL",{"date":83,"type":81},"2026-06-01",{"date":85,"type":71},"2027-01",{"name":5,"class":6},1]