[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608362":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":18,"responsibleParty":31,"collaborators":35,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":18,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":18,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":65,"whyStopped":18,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":18},{"fullName":5,"class":6},"Fudan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Chatbot Intervention Group","EXPERIMENTAL","Participants in this arm will be granted access to an interactive, LLM-powered HPV vaccine chatbot for a period of three months. They are invited to use the chatbot to ask any questions related to HPV and HPV vaccine to receive personalized and accurate information. The chatbot invitation will be sent every weeks to reinforce the intervention within the first month.",[13],"Behavioral: LLM-Powered HPV Vaccine Chatbot",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","NO_INTERVENTION","Participants assigned to the control arm will receive standard care but will not have access to the HPV vaccine chatbot during the study period. For ethical considerations, participants in this arm will be offered access to the chatbot after the end of the study.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","LLM-Powered HPV Vaccine Chatbot","A vaccine chatbot delivered via WeChat or a web browser, designed to provide information and health education about the HPV vaccine. The chatbot is powered by large language models and is trained on an expert-validated knowledge base derived from authoritative sources such as the WHO and China CDC to ensure accuracy. The knowledge base is validated by experts. The chatbot engages users in interactive, conversational dialogue to answer questions and address concerns regarding HPV and HPV vaccines.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Zhiyuan Hou, PhD","CONTACT","86+21 54231112","zyhou@fudan.edu.cn",{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Zhiyuan Hou","Associate Professor",[36],{"name":37,"class":38},"Merck Sharp & Dohme LLC","INDUSTRY","100608362","evaluation-of-a-vaccine-chatbot-on-hpv-vaccine-confidence-and-hesitancy-100608362",false,"NCT07200570","Evaluation of a Vaccine Chatbot on HPV Vaccine Confidence and Hesitancy","Evaluation of a Vaccine Chatbot on HPV Vaccine Confidence and Hesitancy: a Randomized Controlled Trial and Implementation Science Study","Inclusion Criteria:\n\n* Female, aged 15 to 26 years, inclusive.\n* Not previously vaccinated against HPV.\n* Reports no contraindications to HPV vaccination.\n* Has no mental, visual, or reading impairments that would preclude cooperation with study activities.\n* Is willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Male.\n* Age under 15 or over 26 years.\n* Has a history of prior HPV vaccination.\n* Has a known contraindication to HPV vaccination.\n* Unable to comply with study procedures.\n* Is unwilling or unable to provide informed consent.",true,"FEMALE","15 Years","26 Years",{"count":51,"type":52},1800,"ESTIMATED","INTERVENTIONAL",[55],"NA","The goal of this clinical trial is to learn if a chatbot powered by artificial intelligence works to improve HPV vaccination among females aged 15 to 26 in China. A randomized controlled trial and implementation science study will be conducted targeting females as participants. The main questions it aims to answer are:\n\n1. Does the vaccine chatbot influence women's confidence, literacy, hesitancy, and uptake of the HPV vaccine.\n2. What are the public acceptance of chatbot and the facilitators and barriers to its implementation in a real-world setting.\n\nResearchers will compare a group of women who use the chatbot with a group who do not use it to see if the chatbot is effective at helping women feel confident and willing to get vaccinated against HPV.\n\nParticipants will:\n\n1. Be recruited and randomly allocated into one of two groups. One group will be invited to use the HPV vaccine chatbot and the other group will not get access to the vaccine chatbot until the end of the trial.\n2. Complete a questionnaire survey on their confidence, literacy, and hesitancy on the HPV vaccine.\n3. Have their vaccination status checked at the end of trial.",[58],"HPV Vaccine",[60,61,62,63,64],"HPV","vaccine confidence","chatbot","randomised controlled trial","implementation science","NOT_YET_RECRUITING","2025-09-23",{"date":68,"type":69},"2025-10-01","ACTUAL",{"date":71,"type":52},"2025-09-26",{"date":73,"type":52},"2026-05",{"name":5,"class":6}]