[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642389":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":33,"locations":43,"responsibleParty":223,"collaborators":227,"id":268,"slug":269,"hasResults":270,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":270,"sex":276,"minAge":277,"maxAge":278,"enrollmentInfo":279,"targetDuration":18,"studyType":282,"phases":283,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":296,"whyStopped":18,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":306},{"fullName":5,"class":6},"Universität Duisburg-Essen","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"BEPPO-group","EXPERIMENTAL","Patients in the BEPPO group participate in 3-5 partially standardized, supervised exercise sessions per week (30 minutes each), aiming for at least 78 sessions during the 6-month intervention period. Sessions are delivered in hospital settings (inpatient ward, outpatient clinic, or day clinic) and online during periods at home.\n\nExercises are individually adapted to age, health status, treatment phase, and interests.Primary focus are endurance and strength exercises, additionally coordination, flexibility, and balance exercises. Treatment-related side effects are continuously considered. Online sessions are delivered via video platforms; alternatively, individualized home exercise plans are provided.\n\nAdditionally, patients and families participate in four family-centered exercise counselling sessions to identify barriers and facilitators to physical activity, define individualized goals, and support long-term adherence through increaseing patients intrinsic motivation.",[13],"Behavioral: Partially-standardised, supervised, continuity-of-care exercise intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Patients in the control group do not receive a standardized exercise intervention but may participate in the existing site-specific exercise-related usual care services offered at their respective study sites.\n\nThe availability and extent of these services vary considerably across the 13 participating study sites, ranging from no exercise support to comprehensive hospital-based exercise programs during intensive cancer treatment, depending on local staffing and structural resources.\n\nExisting exercise programs are delivered exclusively within the hospital setting (inpatient ward, outpatient clinic, or day clinic) and are based on local practice rather than a standardized intervention protocol.\n\nNeither online exercise support during periods at home nor structured exercise counselling sessions are part of usual care at any participating study site.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Partially-standardised, supervised, continuity-of-care exercise intervention","Exercise sessions:\n\n3-5x\u002Fweek over 6 months (minimum of 78 sessions in total), duration: 30 minutes, partially-standardised with a primarily focus on strength and endurance exercises, additional components: coordination, flexibility, and balance exercises, supervised by exercise professionals, continuity-of-care achieved through hospital-based (in-patient\u002Fout-patient), and home-based online sessions\n\nExercise counselling:\n\n4x sessions in 12 months, family-centred exercise counselling, primary focus on understanding barriers and facilitators to physical activity and increasing intrinsic motivation for participating in the exercise session",[9],[26,30],{"name":27,"affiliation":28,"role":29},"Miriam Goette","Institut for Movement and Exercise, West German Cancer Center, University Hospital Essen, Essen, Germany","STUDY_CHAIR",{"name":31,"affiliation":32,"role":29},"Freerk T Baumann","Department I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":18,"email":38},"Theresa Heering","CONTACT","0049 201 723 4948","theresa.heering@uk-essen.de",{"name":40,"role":36,"phone":41,"phoneExt":18,"email":42},"Annika Tomanek","0049 201 723 4898","annika.tomanek@uk-essen.de",[44,60,73,86,96,109,122,139,152,165,178,191,207],{"facility":45,"status":18,"city":46,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Charité-Universitätsmedizin Berlin, Department of Pediatric Oncology\u002FHematology","Berlin","Germany","DE",{"type":50,"coordinates":51},"Point",[52,53],13.41053,52.52437,{"lat":53,"lon":52},[56],{"name":57,"role":36,"phone":58,"phoneExt":18,"email":59},"Pablo Hernaiz Driever","0049 30 450666173","pablo.hernaiz@charite.de",{"facility":61,"status":18,"city":62,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"University of Bonn Medical Center, Department of Pediatric Hematology\u002FOncology,","Bonn",{"type":50,"coordinates":64},[65,66],7.09549,50.73438,{"lat":66,"lon":65},[69],{"name":70,"role":36,"phone":71,"phoneExt":18,"email":72},"Gabriele Calaminus","0228 287 33389","gabriele.calaminus@ukbonn.de",{"facility":74,"status":18,"city":75,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Children's Hospital Amsterdamer Straße, ; Clinic for Children and Youth Medicine; Department for pediatric hematology\u002Foncology","Cologne",{"type":50,"coordinates":77},[78,79],6.95,50.93333,{"lat":79,"lon":78},[82],{"name":83,"role":36,"phone":84,"phoneExt":18,"email":85},"Meinolf Siepermann","0049 221 8907 5158","siepermannm@kliniken-koeln.de",{"facility":87,"status":18,"city":75,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":88,"geoPoint":90,"contacts":91},"University Hospital Cologne, Department of Pediatric Oncology and Hematology, Children's Hospital",{"type":50,"coordinates":89},[78,79],{"lat":79,"lon":78},[92],{"name":93,"role":36,"phone":94,"phoneExt":18,"email":95},"Thorsten Simon","0049 221 478 40687","thorsten.simon@uk-koeln.de",{"facility":97,"status":18,"city":98,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"University Hospital Essen, Department of Pediatric Hematology\u002FOncology, Center for Child and Adolescent Medicine, Clinic for Pediatrics III","Essen",{"type":50,"coordinates":100},[101,102],7.01228,51.45657,{"lat":102,"lon":101},[105],{"name":106,"role":36,"phone":107,"phoneExt":18,"email":108},"Uta Dirksen","0049 201 723 8084","uta.dirksen@uk-essen.de",{"facility":110,"status":18,"city":111,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Universitätsmedizin Frankfurt, Department of Pediatrics, Pediatric Oncology and Haematology","Frankfurt",{"type":50,"coordinates":113},[114,115],10.53333,49.68333,{"lat":115,"lon":114},[118],{"name":119,"role":36,"phone":120,"phoneExt":18,"email":121},"Mirjam Dieckelmann","069 6301 85879","dieckelmann@allgemeinmedizin.uni-frankfurt.de",{"facility":123,"status":18,"city":124,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":125,"geoPoint":129,"contacts":130},"Universitätsklinikum Hamburg-Eppendorf, Department of Pediatric Hematology and Oncology, Hubertus Wald Tumor Center, University Cancer Center Hamburg","Hamburg",{"type":50,"coordinates":126},[127,128],9.99302,53.55073,{"lat":128,"lon":127},[131,135],{"name":132,"role":36,"phone":133,"phoneExt":18,"email":134},"Gabriele Escherich","0049 40 7410 53796","escherich@uke.de",{"name":136,"role":36,"phone":137,"phoneExt":18,"email":138},"Simon Elmers","0049 40 7410 52624","s.elmers@uke.de",{"facility":140,"status":18,"city":141,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":142,"geoPoint":146,"contacts":147},"Universitätsklinikum Jena, Klinik für Kinder- und Jugendmedizin","Jena",{"type":50,"coordinates":143},[144,145],11.5899,50.92878,{"lat":145,"lon":144},[148],{"name":149,"role":36,"phone":150,"phoneExt":18,"email":151},"Jana Ernst","0049 07747","jana.ernst@med.uni-jena.de",{"facility":153,"status":18,"city":154,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Department of Pediatric Hematology\u002FOncology","Mainz",{"type":50,"coordinates":156},[157,158],8.28008,49.98185,{"lat":158,"lon":157},[161],{"name":162,"role":36,"phone":163,"phoneExt":18,"email":164},"Jörg Faber","0049 6131 17 8331","faber@uni-mainz.de",{"facility":166,"status":18,"city":167,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Pädiatrische Hämatologie und Onkologie, Zelltherapie Zentrum für Kinder- und Jugendmedizin Eine Kooperation der München Klinik und des TUM Klinikums","München",{"type":50,"coordinates":169},[170,171],13.31243,51.60698,{"lat":171,"lon":170},[174],{"name":175,"role":36,"phone":176,"phoneExt":18,"email":177},"Sabine Kesting","0049 89 3068 7411","sabine.kesting@tum.de",{"facility":179,"status":18,"city":180,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"DIAKONEO Klinik Hallerwiese-Cnopfsche Kinderklinik Nürnberg, Department of Pediatric Hematology and Oncology","Nuremberg",{"type":50,"coordinates":182},[183,184],11.07752,49.45421,{"lat":184,"lon":183},[187],{"name":188,"role":36,"phone":189,"phoneExt":18,"email":190},"Jörg Leyh","0911 3340 4816","Joerg.Leyh@diakoneo.de",{"facility":192,"status":18,"city":193,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":194,"geoPoint":198,"contacts":199},"Klinikum der Landeshauptstadt Stuttgart, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pädiatrie","Stuttgart",{"type":50,"coordinates":195},[196,197],9.17702,48.78232,{"lat":197,"lon":196},[200,204],{"name":201,"role":36,"phone":202,"phoneExt":18,"email":203},"Claudia Blattmann","0049 711 2787 2460","c.blattmann@klinikum-stuttgart.de",{"name":205,"role":36,"phone":18,"phoneExt":18,"email":206},"Dominik Gaser","d.gaser@klinikum-stuttgart.de",{"facility":208,"status":18,"city":209,"state":18,"zip":18,"country":47,"countryCode":48,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"University Medical Center Ulm, Department of Pediatrics and Adolescent Medicine","Ulm",{"type":50,"coordinates":211},[212,213],9.99155,48.39841,{"lat":213,"lon":212},[216,220],{"name":217,"role":36,"phone":218,"phoneExt":18,"email":219},"Miriam Erlacher","073150057001","miriam.erlacher@uniklinik-ulm.de",{"name":221,"role":36,"phone":18,"phoneExt":18,"email":222},"Lisa Nonnenmacher","Lisa.Nonnenmacher@uniklinik-ulm.de",{"type":224,"investigatorFullName":225,"investigatorTitle":226,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Miriam Götte","PD Dr. rer. medic.",[228,230,232,234,237,239,241,243,245,247,249,251,253,255,257,259,262,264,266],{"name":229,"class":6},"University Hospital, Essen",{"name":231,"class":6},"University of Cologne",{"name":233,"class":6},"University of Regensburg",{"name":235,"class":236},"Klinik Hallerwiese-Cnopfsche Kinderklink","UNKNOWN",{"name":238,"class":6},"University Hospital Ulm",{"name":240,"class":6},"Klinikum Stuttgart",{"name":242,"class":6},"University Hospital, Bonn",{"name":244,"class":6},"Jena University Hospital",{"name":246,"class":6},"Universitätsklinikum Hamburg-Eppendorf",{"name":248,"class":6},"Johann Wolfgang Goethe University Hospital",{"name":250,"class":6},"Technical University of Munich",{"name":252,"class":6},"Children's University Hospital Cologne, Germany",{"name":254,"class":6},"Charite University, Berlin, Germany",{"name":256,"class":6},"Johannes Gutenberg University Mainz",{"name":258,"class":236},"University Hospital Cologne",{"name":260,"class":261},"AOK Rheinland\u002FHamburg","INDUSTRY",{"name":263,"class":6},"Techniker Krankenkasse",{"name":265,"class":236},"BARMER Krankenkasse",{"name":267,"class":6},"DAK Gesundheit","100642389","evaluation-of-an-exercise-intervention-during-intensive-medical-treatment-in-pediatric-oncology-100642389",false,"NCT07647471","Evaluation of an Exercise Intervention During Intensive Medical Treatment in Pediatric Oncology.","Evaluation of an Exercise Intervention During Intensive Medical Treatment in Pediatric Oncology (Evaluation BEwegungs- Und sPorttherapeutischer Interventionen Unter Medizinischer Therapie in Der Pädiatrischen Onkologie)","BEPPO","Inclusion Criteria:\n\n* Patients aged ≥3 and ≤18 years\n* Oncological diagnosis with curative treatment intent\n* ≤6 weeks since cancer diagnosis (diagnosis can be initial, secondary or relapse diagnosis)\n* Information and consent procedures feasible in German, English or with using local site resources (e.g., interpreters or multilingual staff)\n* Communication with the patient is possible in German, English or with using local site resources (e.g., interpreters or multilingual staff) during the assessments and intervention\n* Patients insured by German statutory health insurers\n\nExclusion Criteria:\n\n* Patients aged \\\u003C3 and \\>18 years\n* No active medical oncological treatment (e.g., watch-and-wait strategy, surgery without ongoing oncological acute treatment at a pediatric oncology center)\n* Medical limitations that do not allow implementation of the study protocol\n* Life expectancy \\\u003C 6 months\n* Patients not insured by German statutory health insurers (e.g., Privatly insured patients, self-paying patients)","ALL","3 Years","18 Years",{"count":280,"type":281},346,"ESTIMATED","INTERVENTIONAL",[284],"NA","The BEPPO study is a Germany-wide clinical trial investigating whether a structured exercise program can improve physical and mental health in children and adolescents undergoing cancer treatment. Although exercise is known to support recovery and well-being, it is not yet a standard part of pediatric oncology care. The study aims to generate evidence to support the integration of exercise into routine treatment.\n\nA total of 346 patients aged 3 to 18 years are recruited across 13 pediatric oncology centers in Germany. Participants are randomly assigned to either an exercise intervention group or a standard care control group.\n\nChildren in the intervention group take part in a 6-month individualized exercise program with 3-5 sessions per week. The program is delivered across different settings, including inpatient hospital care, outpatient treatment, and home-based training supported by telemedicine. This ensures continuous support throughout the course of medical treatment.\n\nIn addition to supervised exercise sessions, participants receive four structured counseling sessions. These sessions aim to strengthen motivation, address individual barriers to participation, and support long-term engagement in physical activity. The counseling also helps build a strong therapeutic relationship and promotes adherence to the program.\n\nThe exercise intervention is based on established principles of sports science but is individually adapted to each patient's health status, treatment phase, and personal preferences. Each training session follows a structured plan with specific goals, while also considering individual physical and psychological conditions to ensure safety, feasibility, and effectiveness.\n\nThe main objective of the BEPPO study is to improve physical performance, particularly leg strength, which is the primary endpoint. Secondary outcomes include endurance, functional mobility, balance, physical activity levels, fatigue, quality of life, mental well-being, frailty, and treatment-related symptoms and side effects.\n\nIn addition to clinical effectiveness, the study also evaluates how well the intervention can be implemented in routine healthcare settings. This includes assessing adherence, feasibility, and potential barriers and facilitators for integrating exercise into standard care. A health economic evaluation is also conducted in collaboration with health insurance providers to determine cost implications.\n\nOverall, the BEPPO study aims to provide robust scientific evidence on the benefits and feasibility of structured exercise during pediatric cancer treatment. The long-term goal is to establish exercise as a standard component of supportive care in pediatric oncology, improving both short- and long-term outcomes for patients.",[287],"Pediatric Cancer Patients",[289,290,291,292,293,294,295],"Knee extensor strength","Quality of Life","Fatigue","Health economics","Implementation","Physical activity","Exercise","NOT_YET_RECRUITING","2026-06-09",{"date":299,"type":300},"2026-06-15","ACTUAL",{"date":302,"type":281},"2026-07-01",{"date":304,"type":281},"2028-12-31",{"name":5,"class":6},13]