[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574086":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":32,"collaborators":10,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":10,"maxAge":43,"enrollmentInfo":44,"targetDuration":10,"studyType":47,"phases":10,"briefSummary":48,"conditions":49,"keywords":54,"overallStatus":20,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Nantes University Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Cardiac surgery with extracorporeal circulation",null,"Children aged between 0 and 17 undergoing cardiac surgery with extracorporeal circulation.\n\nThe children will have blood samples taken at the same time as the samples already taken for all the children as part of the intra- and post-operative management of cardiac surgery. If necessary, the resection of cardiac tissue planned for cardiac surgery will be preserved for the study. Patients' administrative data will be collected at the time of sampling and anonymised. Medical data will be collected retrospectively from the medical record. Patients will be monitored as part of the post-operative cardiac surgery network and data will be collected retrospectively from the patient's file.\n\nWestern blot analysis (measurement of O-GlcNAcylation) will be carried out as soon as a sufficient number of samples are available in the bio-collection (generally by 15 samples)",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Manon Denis","CONTACT","+33 2 40 08 34 83","manon.denis-med@chu-nantes.fr",[19],{"facility":5,"status":20,"city":21,"state":10,"zip":10,"country":22,"countryCode":23,"cosmosGeoPoint":24,"geoPoint":29,"contacts":30},"RECRUITING","Nantes","France","FR",{"type":25,"coordinates":26},"Point",[27,28],-1.55336,47.21725,{"lat":28,"lon":27},[31],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},{"type":33,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100574086","evaluation-of-blood-and-cardiac-protein-o-glcnacylation-levels-in-cardiac-surgery-in-children-100574086",false,"NCT06754709","Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children","Evaluation of the Levels of O-GlcNAcylation of Cardiac and Blood Proteins in Paediatric Cardiac Surgery and Identification of Therapeutic Targets","CardiOGlcNAc","Inclusion Criteria:\n\n* Age from 0 to 17 years at the time of sampling\n* Children undergoing CEC for cardiac surgery\n* Signed bio-collection consent\n\nExclusion Criteria:\n\n* Children with an infection\n* Children with fever\n* Children with an immune deficiency\n* Children with autoimmune disease\n* Children with metabolic disease\n* Children with haematological diseases\n* Children with a genetic disease\n* Unsigned consent\n* Refusal by parents or child","ALL","17 Years",{"count":45,"type":46},300,"ESTIMATED","OBSERVATIONAL","Cardiac surgery requires the use of extracorporeal circulation (ECC). Age-related differences in inflammatory response, the greater susceptibility of immature organ systems to injury and the larger ratio of extracorporeal circuitry to patient size make younger and smaller patients more vulnerable to organ injury. The main problem associated with ECC in neonates and infants is the duration of ECC due to heavier surgeries leading to a prolonged inflammatory state resulting in capillary leak syndrome, low cardiac output syndrome and organ dysfunction, resulting in higher morbidity and mortality. The means of limiting this inflammatory response remain limited. Future studies should aim to address new post-ECC prophylactic targets to improve myocardial and endothelial function. Cardiac metabolism is an important area of research because it plays a central role in maintaining cardiac function under stress. The study of O-GlcNAcylation could therefore be an interesting therapeutic target, given the beneficial role of its stimulation in acute stress situations, as demonstrated in sepsis.",[50,51,52,53],"Cardiac Surgery","Extracorporeal Circulation; Complications","Metabolism","Low Cardiac Output",[55,56,57,58,59,60],"cardiac surgery","extracorporeal circulation","metabolism","low cardiac output","O-GlcNAcylation,","systemic inflammatory response syndrome","2025-04-10",{"date":63,"type":64},"2025-04-13","ACTUAL",{"date":66,"type":64},"2025-02-13",{"date":68,"type":46},"2035-01-31",{"name":5,"class":6},1]